Hebei Medical University

XGBoost–SHAP-based interpretable predictive website for postoperative in-hospital mortality in patients with acute aortic dissection

Developing a convenient and accurate prognostic model for patients with acute aortic dissection (AAD) using routine demographic and clinical data is challenging. This study aimed to develop an interpretable web-based prediction model using extreme gradient boosting with Shapley a...

Fluoroscopic Catheter-Tip Positioning During Internal Jugular TIVAD Placement in Breast Cancer: A Two-Center Retrospective Cohort Study

Background/Objectives: Fluoroscopy permits direct assessment of catheter course and tip position during totally implantable venous access device (TIVAD) placement. We compared left- and right-sided internal jugular vein (IJV) port placement in breast cancer. Methods: This retrosp...

Reversal of Chronic Stress‐Induced Inflammaging by Bazi Bushen Formula Through AMPK‐Sirtuins Axis Activation and Myeloid Reset

ABSTRACT Chronic stress potentially accelerates aging and increases age‐related disease risk. However, the underlying mechanisms and organ specificity remain unclear. Utilizing a 12‐month unpredictable chronic mild stress (UCMS) mouse model, we revealed chronic stress significant...

One‐Step Induction of Oogonia‐Like and Pro‐Spermatogonia‐Like Cells From Porcine Pluripotent Stem Cells

ABSTRACT Pigs share a germ cell regulatory network highly similar to that of humans, yet lack a robust system for inducing and expanding germ cells from pluripotent stem cells, impeding large‐animal gametogenesis research. Here, we established a modular platform capable of effici...

Evaluation of the efficacy of oral propranolol combined with pulsed dye laser versus monotherapy with oral propranolol in the treatment of mixed infantile hemangiomas

Oral propranolol is first-line for problematic infantile hemangiomas (IHs) but often leaves superficial residual lesions. This study assessed the efficacy and safety of adding pulsed dye laser (PDL) to propranolol versus propranolol alone for mixed IHs. This single-center retrosp...

Effects of metallic components in ambient PM₂.₅ on pediatric respiratory diseases in Shijiazhuang

Considerable attention has been paid to the short-term association between ambient PM 2.5 exposure and children’s respiratory health, yet evidence on individual and combined exposure to its metal components remains limited, especially in typical industrial cities. Based on daily...

Clinical and imaging predictors of cerebrovascular stroke in patients with acute isolated dizziness/vertigo: a retrospective cohort study

Abstract Background Acute isolated dizziness/vertigo represents a significant diagnostic challenge, as it can be the sole manifestation of posterior circulation stroke. This study aimed to identify clinical and imaging features associated with stroke in a specific high-risk subgr...

Efficacy and Safety of Chemically Synthesized Semaglutide Injection ( HD1916 ) for the Treatment of Obesity: A Multicenter, Randomized, Phase III Trial

ABSTRACT Aims To evaluate whether HD1916, a chemically synthesised semaglutide, is therapeutically equivalent to the reference product semaglutide (Wegovy) in body weight reduction among Chinese adults with obesity without diabetes. Materials and Methods This multicenter, randomi...

Therapeutic targeting of TCF/LEF transcription factors in neuropsychiatric disorders via Wnt/β-catenin signaling

The T-cell factor/lymphoid enhancer-binding factor (TCF/LEF) family, comprising TCF1, LEF1, TCF7L1, and TCF7L2, serves as nuclear effectors of the canonical Wnt/β-catenin signaling pathway and plays pivotal roles in neurodevelopment, synaptic plasticity, neuroinflammation, and ce...

Association between respiratory phenotypes and successful ventilator liberation in early-onset and late-onset ARDS: a multicenter cohort study

Early-onset and late-onset acute respiratory distress syndrome (ARDS) differ in clinical course and outcomes, but their longitudinal respiratory trajectories remain unclear. We aimed to characterize respiratory trajectories in early- and late-onset ARDS and identify trajectory-ba...

Early dynamic physiological phenotypes and bidirectional temporal associations between muscle attrition and functional decline in advanced hcc undergoing systemic therapy: a landmark analysis

Abstract Background Early treatment-related physiological changes are increasingly recognized as prognostic indicators in advanced hepatocellular carcinoma (HCC), yet they are rarely integrated into routine response assessments. This study aimed to characterize early dynamic phys...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

Ammonia Accumulation Drives Intervertebral Disc Degeneration by Triggering Ammonia‐Induced Cell Death Through Lysosome–Mitochondria Crosstalk

ABSTRACT Intervertebral disc degeneration (IVDD) is a major cause of low back pain and is closely associated with metabolic imbalance within the disc microenvironment, yet the underlying mechanisms remain poorly understood. Here, we identify ammonia accumulation as a metabolicall...

PediatricLiver score: a novel risk score for screening elevated liver stiffness in the pediatric population (CHESS2401)

Given the looming crisis of rapid increase in childhood obesity globally, chronic metabolic diseases have consequently emerged but without sufficient awareness among children. Reliable and accessible screening tools thus are required to screen for significant liver fibrosis in th...

F-Convexity of Real Functions

Let F be a family of sets in Rd. A set M⊂Rd is called F-convex if for any points x,y∈M there is a set F∈F such that x,y∈F and F⊂M. A function f:R→R is called F-convex if its epigraph is F-convex. In this paper we investigate various F-convexities for real functions

Brodifacoum poisoning complicated by intestinal necrosis

Dear Editor,Brodifacoum is a potent, long-acting second-generation 4-hydroxycoumarin anticoagulant rodenticide that inhibits vitamin K epoxide reductase, impairing hepatic synthesis of coagulation ...

Metabolic-epigenetic nanoregulator attenuates a folate-deficiency-associated senescence phenotype in intervertebral disc degeneration

Intervertebral disc degeneration (IVDD) is increasingly recognized as an aging-associated disorder driven in part by nucleus pulposus cell (NPC) senescence, yet the nutrient-sensitive metabolic defects that sustain this state remain poorly understood. Here, we investigated impair...

Shared Resistance, Phage-Receptor, and Biofilm Determinants in Antibiotic-Resistant Pseudomonas aeruginosa, Escherichia coli, and Acinetobacter baumannii: A Bibliometric and Gene-Network Analysis of Phage Cocktail Research

Background/Objectives: Antimicrobial resistance has renewed interest in bacteriophage cocktails as antibacterial and adjunctive agents, but the global research landscape and the bacterial determinants that constrain cocktail performance have not been mapped within a single framew...

Glioblastoma mimicking a cerebral cavernous malformation: case report

Glioblastoma is the most common malignant tumor of the central nervous system, and its diagnosis is typically straightforward based on clinical and neuroimaging data. However, when glioblastoma and cavernous hemangioma exhibit overlapping MRI features, the diagnosis becomes chall...

Association between thyroid function profiles and malnutrition severity in elderly patients

Aim To explore the of triiodothyronine (rT3) in the prognostic model of malnutrition in the elderly. Methods A total of 166 elderly patients with malnutrition were included in the experimental group, and 98 healthy people were collected as the control group. The six thyroid funct...