Hainan Medical University

Comparison of three interpretation criteria for [⁶⁸Ga]Ga-DOTATATE PET/CT in suspected pheochromocytoma and paraganglioma of the adrenal gland or retroperitoneal space

Pheochromocytomas and paragangliomas (PPGLs) frequently overexpress somatostatin receptor subtype 2 (SSTR2), making [ 68 Ga]Ga-DOTATATE PET/CT a promising functional imaging modality. However, the optimal interpretation criteria for distinguishing PPGL from non-PPGL lesions in cl...

A nose-to-brain circuit underlies anxiety regulation by nasal afferent frequency in mice

Slow nasal breathing alleviates negative moods, but the precise nose-to-limbic pathways and their causal contributions remain unclear. Here, we identify a pathway in mice from olfactory sensory neurons (OSNs) in the nasal cavity to mitral cells in the olfactory bulb (OB), then to...

Mental health knowledge-stigma profiles among primary healthcare workers involved in severe mental disorder management in Hainan, China

Under China’s Project 686 and the National Basic Public Health Service Program, primary healthcare workers play a central role in the community management of severe mental disorders. However, little is known about heterogeneity in mental health knowledge and perceived public stig...

The relationship between preoperative anxiety, self-efficacy, and positive coping style in lung cancer patients undergoing video-assisted thoracoscopic surgery: a cross-sectional study

Abstract Background Patients with lung cancer undergoing video-assisted thoracoscopic surgery (VATS) may experience preoperative anxiety arising from cancer-related uncertainty and surgery-related concerns. Although VATS is less invasive than conventional thoracotomy, patients ma...

Latent subtypes and gender differences in the comorbidity of depression and sleep disturbances among adolescents: insights from network analysis and latent profile analysis

This study aimed to explore potential subtypes, influencing factors, and gender differences in the associations between adolescent depression and sleep disorders. A cross-sectional study was conducted among adolescents utilizing the Center for Epidemiologic Studies Depression Sca...

Dysbiosis of gut fungi and bacteria in patients with HBV with low-level viremia compared with sustained virologic responders and healthy controls

Although bacterial dysbiosis in chronic hepatitis B (CHB) is well established, the role of the gut mycobiome-particularly its functional interplay with bacteria during virological remission versus treatment failure remains unexplored. In this study, the gut bacteriome and mycobio...

A community-based online machine learning platform for predicting rapid decline in kidney function: a nationwide cohort study

Rapid decline in kidney function (RDKF) is an early and modifiable precursor of chronic kidney disease, yet proactive risk identification remains limited in community-based populations. This study aimed to develop, validate, and deploy an interpretable machine learning model to p...

Diversity and Bioprospection of Functional Proteins from Sea Anemone Heteractis magnifica Based on Multi-Omics Approach

Sea anemone venom has attracted increasing attention in biomedical research due to its multifarious compounds with biological activities. Although the venom is predominantly made up of proteins, the diversity and complexity of these proteins remain poorly understood. In this work...

Long-term body roundness index profiles and incident diabetes in middle-aged and older Chinese adults: a longitudinal analysis of CHARLS 2011–2020

Higher body roundness index (BRI) is associated with diabetes, but trajectory classes derived from a small number of repeated measurements may primarily reflect average BRI level. We examined whether sustained BRI profiles were associated with incident diabetes and, secondarily,...

Species discordance in diatom testing for drowning diagnosis: a biological passive sampling hypothesis with forensic implications

Diatom testing is a key technique for forensic drowning diagnosis, yet species discordance between diatom taxa in victim tissues and water samples from the recovery site remains a major medico-legal challenge, often misattributed to technical errors or post-mortem contamination....

Magneto‐NIR‐II‐Programmed Cascade Nanozymes Unlocking Blood–Brain Barrier Translocation and Autophagic Resistance in Glioblastoma

ABSTRACT Glioblastoma (GBM) remains a highly aggressive central nervous system malignancy, and its treatment is hindered by poor drug accumulation across the blood–brain barrier (BBB) and autophagy‐mediated repair. To address these barriers, rare‐earth‐doped Nd 0.02 Fe 2.98 S 4 @...

Single-cell transcriptomics uncovers HPV-driven immune evasion and establishes a TAB2-based prognostic signature in cervical cancer

Background Persistent human papillomavirus (HPV) infection is a key driver in cervical cancer, yet the molecular mechanisms linking HPV to immune escape remain incompletely understood. Methods We integrated single-cell RNA sequencing (scRNA-seq), bulk transcriptome, and clinical...

Analysis of the prevalence of positivity for tuberculosis infection in formalin-fixed paraffin-embedded tissue

Abstract Background The objective of this study was to analyze the tuberculosis(TB) positivity rate of formalin-fixed paraffin-embedded (FFPE) tissue samples, to explore the difference between the positivity rates of pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (E...

First detection of Leishmania infantum in dogs and wild-caught Culicoides oxystoma in Hainan Province, Southern China

Leishmaniases are neglected parasitic diseases expanding globally. In China, Leishmania infantum , which isendemic in the west, has reemerged and spread to the central part of the country, raising concerns about further potential expansion. Given limited data from southern China,...

Assessing Cultivated Land Abandonment in Hainan Island: Spatio-Temporal Differentiation and Driving Mechanism

Cultivated land abandonment poses a growing threat to regional food security and sustainable land resource allocation in tropical island regions, making the accurate identification of its spatio-temporal characteristics and driving mechanisms an urgent research priority. This stu...