Guizhou University

Cellular Senescence and Immune Dysregulation in Acute-on-Chronic Liver Failure: A Case Report Integrating Single-Cell and Spatial Transcriptomic Profiling

Background: Acute-on-chronic liver failure (ACLF) is a clinical syndrome characterized by acute decompensation of cirrhosis, systemic inflammation, and high short-term mortality (1). The underlying mechanisms involve a complex interplay between cellular senescence, immune dysregu...

Prioritizing key performance indicators for maintenance management in public hospitals: a hybrid SEM–machine learning approach

Purpose Public hospital maintenance operates under growing service pressure, yet existing frameworks often rely on data-intensive systems or broader facility outcomes, offering limited guidance on which maintenance key performance indicators (KPIs) should be prioritized under res...

NtNAC50–NtEXLB1 module enhances cadmium tolerance by strengthening root antioxidant defence and maintaining root structural homeostasis

Cadmium (Cd) contamination inhibits plant growth and threatens the safe production of crops, but the root-mediated regulatory mechanisms that simultaneously enhance Cd tolerance and reduce tissue Cd accumulation remain incompletely understood. This study aimed to determine the fu...

A streamwise partitioned variable-density plate-fin heat sink for downstream thermal bottleneck mitigation with improved temperature uniformity

When multiple heat sources are arranged sequentially along the airflow direction in power electronic equipment, streamwise air heating weakens the downstream heat-transfer driving force, causing outlet-side hot spots and temperature non-uniformity. Building on established variabl...

Identification of Syringic Hydrazide Derivatives as Promising Succinate Dehydrogenase Inhibitors with Superior Antifungal and Anti-Oomycete Efficacy for Ensuring Food Safety

Abstract Fungal diseases remain a major constraint on global crop production, driving the search for fungicides with broader efficacy and improved selectivity. Confronting the dual challenges of structural rigidity and declining antifungal performance in conventional succinate de...

Blastocyst-Derived Lactic Acid Regulates Uterine Epithelial Receptivity and Stromal Decidualization via the HIF1α-HO-1-Heme Metabolic Axis

Successful embryo implantation requires intimate crosstalk between the blastocyst and the uterine epithelium within a defined window of receptivity. However, the metabolic signals that mediate this process in mammals remain poorly understood. In this study, pregnant mice, primary...

A two-step phosphorus–sulfur wet-process phosphoric acid route enabling simultaneous rare earth leaching and co-production of high-whiteness hemihydrate gypsum whiskers

The conventional wet-process phosphoric acid production results in most associated rare earth elements (REEs) being retained in phosphogypsum, rendering their recovery uneconomical. To address this challenge, this study proposes a novel two-step phosphorus-sulfur wet process. In...

Conservation gaps, taxon-specific mechanisms, and synergistic benefits of amphibian-centered planning in a karst biodiversity hotspot

Habitat loss, climate change, and disease are driving global amphibian declines, making amphibians valuable indicators for conservation assessment. We integrated field surveys (2013–2025) covering 120 amphibian species in Guizhou, a karst biodiversity hotspot, with species distri...

Advances in Enzyme Immobilization and Its Application in the Degradation of Typical Emerging Contaminants

ABSTRACT Emerging contaminants (ECs), including pharmaceuticals and personal care products (PPCPs), endocrine‐disrupting chemicals (EDCs), pesticides, and polycyclic aromatic hydrocarbons (PAHs), have attracted increasing attention due to their persistent occurrence and potential...

Age-related shifts of dissolved hydrogen and its impact on rumen fermentation dynamics and microbial communities in goats (Capra hircus)

Abstract The rumen is a complex anaerobic fermentation ecosystem in which microbial communities undergo dynamic changes during host development, influencing fermentation efficiency, hydrogen utilization, and methane (CH₄) production. However, how rumen maturation reshapes hydroge...

Flavonoid Biosynthesis Mediated by GmF3Hs Contributes to Drought Tolerance in Soybean

Flavonoids are central to abiotic stress responses, yet the specific signaling roles and evolutionary dynamics of flavonoid biosynthetic intermediates in crop drought adaptation remain elusive. Here, we demonstrate that dihydrokaempferol (DHK) and dihydroquercetin (DHQ), specific...

Novel R2R3-MYB transcription factor CsMYB39 influences epigallocatechin gallate biosynthesis in tea plant (Camellia sinensis) by regulating CsSCPL11-IA gene expression

Epigallocatechin-3-gallate (EGCG) is the most bioactive galloylated catechin in tea ( Camellia sinensis (L.) O. Kuntze) plants. Its biosynthesis is precisely regulated by transcription factors. In this study, we used the promoter of the CsSCPL11-IA gene, which encodes a key enzym...

Rhizosphere Bacterial Communities of Two Coastal Halophytes Under Salinity–Flooding Stress

Soil salinisation and periodic flooding jointly shape coastal wetland ecosystems, but how coexisting halophytes differ in their rhizosphere bacterial communities under these conditions remains insufficiently understood. Here, we investigated rhizosphere bacterial communities asso...

Tomato leaf waste extract as corrosion inhibitor for copper–nickel alloy in H2SO4 medium

Abstract The tomato leaf waste extract (TLWE) was obtained through a decoction process and its effectiveness as a corrosion inhibitor on a copper–nickel alloy in sulfuric acid was assessed. Electrochemical measurements demonstrated that the extract functions as a mixed inhibition...

Design and synthesis of 1,2,4-oxadiazole-functionalized funtumine derivatives as potent anticancer agents

A series of innovative 1,2,4-oxadiazole-functionalized funtumine derivatives were designed, synthesized, and assessed for their antiproliferative effects on HCT116, HeLa, and HepG2 human cancer cell lines to discover new natural product-derived anticancer agents. The majority of...

Time–frequency collaborative denoising for audio-magnetotelluric data using a wavelet-based residual network

Abstract The Audio-Magnetotelluric (AMT) method is a key geophysical technique for mineral resource exploration, but anthropogenic electromagnetic interference severely downgrades the data quality. In recent years, neural networks have shown results superior to traditional method...

SGO-DN-AF model for evaluating industry–academia collaboration in talent development

Abstract Background Effective industry-academia collaboration (IAC) is critical for developing industry-ready talent in the age of digital transformation. Traditional assessment approaches for IAC frequently rely on linear or subjective analysis, which fails to reflect the multid...

Effect of Baijiu bottom pot water on the chemical composition, microbial community and in vitro ruminal fermentation of king grass silage

Bottom pot water (BPW), a distillation by-product from the Baijiu industry, is rich in organic compounds but poses a disposal challenge. This study investigated the effects of BPW and Lentilactobacillus buchneri , on fermentation quality, chemical profiles, and bacterial communit...

Phased fuel transitions for decarbonizing the Asia–Europe Green Shipping Corridor

Shipping remains almost entirely reliant on fossil fuels, and identifying viable fuel transition pathways under evolving regulations is a key challenge. A study now evaluates 13 alternative marine fuels for the Asia–Europe corridor, revealing phased transitions shaped by policy d...

Divergent Synthesis of Functionalized Spiroindanediones via CdI2/MgI2-Catalyzed Multiple Cyclocondensation Modes

Abstract Divergent synthesis enables rapid construction of structurally diverse compound libraries from the same universal substrates and is a current research hotspot. Here, the self-(3 + 2), (2 + 1), and (1 + 1 + 1) cyclocondensations of 2-arylidene-1,3-indanediones 1 were real...