Guizhou University

Bardoxolone methyl exerts an inhibitory effect on respiratory syncytial virus infection by downregulating IL-6 via the IKKβ/NF-κB signaling pathway

ABSTRACT Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections in infants, older adults, and immunocompromised individuals, but therapeutic options for active infection remain limited. Interleukin-6 (IL-6) contributes to RSV replication and RSV-induce...

Thermal Lag Characteristics During the Cooling Process of Coal Spontaneous Combustion Under Different Nitrogen Concentrations

Coal spontaneous combustion poses a major hidden danger to coal‑mine safety production, and the inhibition effect of nitrogen injection is closely related to the temperature response of coal during the cooling stage. In this study, Xiaolongtan (XLT) lignite was selected as the ex...

Ecotoxicity of bauxite residue leachates during amendment-assisted revegetation: Multi-organ oxidative and genotoxic effects and gut microbiota shifts in zebrafish

Vegetation restoration is increasingly applied to mitigate environmental risks from bauxite residue disposal areas; however, how amendment-assisted revegetation alters leachate chemistry and affects aquatic organisms remains unclear. In this study, separate groups of adult zebraf...

Combined Effects of In Situ Stress and Moisture on CO2 Adsorption Characteristics in Deep Coal Seams

Abstract Deep coalbed methane (CBM) has emerged as an indispensable resource for expanding worldwide natural gas production and reserves. Nevertheless, the combined impact of in situ stress and moisture on gas adsorption properties under deep geological conditions remains poorly...

A Honeybee-Safer Pyrazolyl Pyrido[1,2- a ]pyrimidine Mesoionic Targeting Fall Armyworm nAChR α1/β2 Subunits

Abstract Spodoptera frugiperda is a highly destructive pest with widespread resistance to conventional insecticides. Mesoionic chemicals are promising for insecticide discovery, yet lepidopteran-active examples remain limited and many raise pollinator-safety concerns. Here, we re...

Na2CO3 induced crystal growth assisted ilmenite reduction and cyclic wet magnetic separation coupling to achieve efficient separation of titanium and iron

In this study, we employed a Na 2 CO 3 -enhanced reduction process coupled with cyclic wet grinding and magnetic separation for effective utilization of low-grade ilmenite. The process was designed to produce a high-grade titanium-rich product. This study systematically investiga...

Synergistic Interfacial Anchoring and Defect Regulation via SAMs for Highly Stable Flexible Electrochromic Energy Storage Devices

ABSTRACT Flexible electrochromic energy storage devices (FECESDs) are highly promising for wearable electronics, integrating tunable optoelectronic properties with efficient energy storage. However, weak interfacial chemical anchoring and resultant mechanical delamination between...

Dietary Fermented Mulberry Leaf Triggers Dose-Dependent Changes in Growth, Antioxidant Immune Status and Intestinal Microecology of Amur Sturgeon (Acipenser schrenckii)

Mulberry leaf is a promising sustainable plant-based feed resource; however, high dietary inclusion of raw mulberry leaf impairs growth in carnivorous fish. Fermentation degrades anti-nutritional components and enhances nutrient availability, yet the dose-dependent effects and un...

Multifunctional Ca9Na 1-y Li y Y2/3(PO4)7-Based Phosphors: Li+/Na+ Substitution-Regulated Site-Related Eu2+ Emission and Eu2+→Mn2+ Energy Transfer

Abstract Activator-ion coordination in multisite inorganic hosts is key to luminescence modulation and multifunctional integration. However, most phosphor studies address limited functions, and single-host multiscenario platforms remain scarce. Herein, we report a β-Ca3(PO4)2-typ...

Influence of supercritical CO2-water soaking on fracture toughness of shale: Implications for shale gas recovery and CO2 sequestration

The fracture toughness of shale influences fracture network formation and CO 2 storage stability in shale reservoirs. To investigate this effect, semi-circular bending (SCB) tests and measurements of surface energy, fracture surface roughness, and mineral compositions were conduc...

Pathogen detection and gut microbiota analysis in subcutaneous abscesses in goats

Subcutaneous abscesses in goats result in carcass condemnation, reduced milk and wool production, growth retardation, and increased mortality, thereby causing substantial economic losses in goat production systems. This study investigated the major pathogens associated with subcu...

Dual-functional (NiPS3 NSs + BP QDs)@In2O3 heterojunction for synergistic photocatalytic degradation of antibiotics and hydrogen evolution

The elimination of emerging organic contaminants and the exploitation of clean hydrogen energy are critical research topics in environmental remediation. Indium oxide (In 2 O 3 ) serves as a promising dual-functional photocatalyst with low resistivity and high catalytic activity,...

Wear and Corrosion Resistance of FeCoNiCrNbx High‐Entropy Alloy Coatings Prepared by Laser Cladding

304 stainless steel is extensively applied in diverse fields, yet exhibits inadequate wear and corrosion resistance under service conditions.Compared with conventional single FCC‐phase high‐entropy alloy coatings, eutectic high‐entropy alloy (EHEA) coatings exhibit superior syner...

Integrated transcriptomics and metabolomics reveal key metabolic pathway responses in Myzus persicae (Sulzer) to facilitate arbovirus transmission under cold stress

Cold stress markedly alters the ability of Myzus persicae to acquire and transmit Potato virus Y (PVY). Using a synchronized multiomics approach combining electropenetrography, untargeted metabolomics and RNA-Seq, we found that cold stress reduced PVY expression and host choice r...

Iron-Enriched Carbonized Straw Reduces Rice Antimony Accumulation by Shifting the Dominant Antimony Sink from Soil Adsorption to Root-Surface Iron Plaque Sequestration

Abstract Straw return is widely practiced in paddies, yet its role in antimony (Sb) transfer from soil-to-rice remains unclear. This study compared raw straw, carbonized straw (CR), and iron–manganese-enriched carbonized straw (FMCR) to resolve dynamic coupling among rhizosphere...

Modulating the Pore Environment of a Hydrogen‐Bonded Organic Framework for Efficient Separation of a Ternary Mixture of Methanol‐to‐Olefin Products

ABSTRACT Developing energy‐efficient adsorbents for one‐step purification of ethylene (C 2 H 4 ) from ternary methanol‐to‐olefins (MTO) product mixture remains highly important but essentially unexplored in hydrogen‐bonded organic frameworks (HOFs). Herein, an ultramicroporous HO...

Resilient modulus characteristics and model prediction of cement phosphogypsum under dry-wet cycling conditions

The subgrade resilient modulus is a crucial parameter in pavement structure design, directly related to the safety and economy of the pavement structure. Currently, the subgrade resilient modulus used in pavement structure design is the static resilient modulus. To address this i...

Effects of maize straw-derived biochar on soil nutrient dynamics and nematode community structure in upland yellow soil

Biochar, a carbon-rich soil amendment, has considerable potential to enhance soil fertility, promote carbon sequestration, mitigate greenhouse gas emissions, and support sustainable agricultural development. However, in upland acidic yellow soil regions, the responses of soil nem...

Exogenous GA3 promotes flower bud differentiation in Lycoris aurea by modulating hormone signaling and carbohydrate metabolism

Lycoris aurea Herb. (golden spider lily) exhibits a prolonged vegetative phase and delayed flowering, limiting its ornamental and commercial value. Gibberellins, particularly GA 3 , are well-known regulators of flower bud differentiation in plants. Here, we investigated whether e...

Cellular Senescence and Immune Dysregulation in Acute-on-Chronic Liver Failure: A Case Report Integrating Single-Cell and Spatial Transcriptomic Profiling

Background: Acute-on-chronic liver failure (ACLF) is a clinical syndrome characterized by acute decompensation of cirrhosis, systemic inflammation, and high short-term mortality (1). The underlying mechanisms involve a complex interplay between cellular senescence, immune dysregu...