Guangzhou University of Chinese Medicine

Study on pathways to improve the capacity for vertical collaboration of medical personnel in county-level medical alliances: an empirical exploration based on the CLFI collaboration model

To explore the key factors affecting the vertical collaboration of county and township medical personnel within county-level medical alliances and the paths for improvement, in order to provide suggestions for enhancing the intrinsic motivation for collaboration among county and...

Identification of SGK1 as a candidate regulator associated with myeloid cell senescence in ME/CFS: An integrative transcriptomic and experimental study

Background Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex illness lacking objective diagnostic biomarkers and clear pathophysiological understanding. Patients exhibit immune dysregulation and chronic inflammation reminiscent of aging phenotypes, yet the...

Single-cell transcriptomics and machine learning characterize LTA4H-linked lipid metabolism and inflammatory signatures in the knee osteoarthritis IPFP/synovium compartment

Knee osteoarthritis (KOA) is a whole-joint disease characterized by inflammation, immune dysregulation, and metabolic imbalance. To define lipid metabolism-related transcriptional heterogeneity within the infrapatellar fat pad (IPFP)/synovium compartment, we integrated publicly a...

Association of Long-Term Residentially Assigned Speciated Atmospheric Mercury Emission Flux with All-Cause and Cause-Specific Mortality

Abstract Mercury (Hg) is a persistent global pollutant, but population evidence on residentially assigned species-specific atmospheric Hg emission flux and mortality is limited. We analyzed UK Biobank cohorts for all-cause/other-cause (N = 322,666), cardiovascular disease (N = 34...

Ejiao (Asini Corii Colla) promotes thin endometrium repair via upregulation of the SDF-1/CXCR4 signalling axis in a mouse model

Background Thin endometrium (TE) severely impairs embryo implantation and pregnancy outcomes in reproductive medicine, while first-line oestrogen-based therapy has marked limitations including receptor insensitivity and systemic side effects. Ejiao (Asini Corii Colla), a classic...

Circulating and tumor microenvironment immunomarkers associate with immunotherapy efficacy in advanced bladder urothelial carcinoma: an exploratory multicenter study integrating genomic and immunophenotypic profiling

Aims To elucidate the efficacy-predictive values of immunomarkers in both peripheral blood and tumor tissue in patients with advanced bladder-urothelial-carcinoma (aBUC) undergoing first-line immunotherapy.Patients and methods In previously untreated aBUC, T-cell subclusters and...

PD-1 inhibitor-associated myasthenia gravis with acute myocardial injury: a case report

Abstract Background PD-1 inhibitors can cause serious immune-related adverse events, including myasthenia gravis (MG). The occurrence of myocardial injury during immune checkpoint inhibitor therapy can pose diagnostic challenges. Case presentation A 65-year-old man with hepatocel...

Integrative bioinformatics analysis of Lianmei granules in diabetic nephropathy

Diabetic nephropathy (DN) is a severe complication of diabetes mellitus, leading to end-stage renal disease and significant morbidity. Current therapies are limited by efficacy and side effects, highlighting the need for novel treatments. Lianmei granules (LMG) show potential for...

Combining network toxicology with machine learning and experiment validation to analyze the molecular mechanism and core target screening of aristolochic acid nephropathy

Aristolochic acid nephropathy (AAN), a rapidly progressive kidney disease caused by aristolochic acid (AA), frequently progresses to end-stage renal disease and lacks effective therapy. The molecular targets that couple AA exposure to renal injury remain further defined. This stu...

Ligustrazine Alleviates Nitroglycerin‐Induced Migraine by Regulating Mitochondrial Energy Metabolism Through the Concurrent Regulation of CypD, ANT, and PAR2

ABSTRACT To investigate the protective effects of ligustrazine (Lig) against nitroglycerin (NTG)‐induced migraine and explore its underlying mechanisms, with a particular focus on mitochondrial energy metabolism and the coordinated regulation of protease‐activated receptor 2 (PAR...

Reproductive history and age at natural menopause in US women: a cross-sectional analysis of National Health and Nutrition Examination Survey 1999 to March 2020

Objective: The associations of parity and gravidity with age at natural menopause (ANM) remain incompletely characterized. We examined parity‐ANM and gravidity‐ANM associations and explored non‐live-birth pregnancies descriptively in a nationally representative sample of US women...

Sulfur dioxide exposure is associated with kidney dysfunction and creatinine abnormalities in Chinese patients with cardiovascular disease or hypertension

This observational study examined the association between long-term ambient air pollution exposure and renal dysfunction among middle-aged and elderly Chinese individuals with hypertension or heart disease. Although previous studies have mainly focused on particulate matter and n...

Cardiometabolic medicine in China: Burden, challenges, and strategic priorities

The development of cardiometabolic medicine (CMM) reflects a shift in cardiovascular disease (CVD) management from organ-based care toward greater cross-system integration. CMM integrates cardiovascular, endocrine, renal, and public health domains to address the bidirectional int...

Dual pH/glucose-responsive berberine-loaded bioactive glass/carboxymethyl chitosan hydrogel for promoting diabetic wound healing

Diabetic wounds are characterized by a complex pathological microenvironment involving hyperglycemia-induced oxidative stress, persistent inflammation, bacterial infection and impaired matrix remodeling. In this study, we developed BBGgel, an injectable pH- and glucose-responsive...

SCAN-FIQA: Multi-scale cross-attention network for fundus image quality assessment

Currently, the performance and reliability of AI-driven fundus image diagnostic models are critically constrained by the quality of real-world data. However, in clinical scenarios, the quality of fundus images often varies significantly due to factors such as differences in imagi...

Distribution characteristics and risk factors of hidden blood loss in three posterior minimally invasive spinal fusions: a retrospective study of 158 patients

To investigate the perioperative blood loss distribution and independent risk factors for hidden blood loss (HBL) in three posterior minimally invasive lumbar interbody fusion techniques: minimally invasive transforaminal lumbar interbody fusion (Mis-TLIF), unilateral biportal en...

Methyl eugenol increases neural microcirculation to promote nerve repair by regulating endothelial cell and Schwann cell communication via Ptn/Sdc4

Neuromicrocirculatory disorders often accompany nerve injury. Improving neural microcirculation can promote the repair of injured nerves. Methyl eugenol is a major bioactive component of Asarum heterotropoides and has been reported to exert analgesic effects in chronic pain. This...

New guidelines for the prevention of periprosthetic joint infection

Periprosthetic joint infection (PJI) remains one of the most serious complications of arthroplasty. Since the publication of major guidelines, several aspects of the prevention of PJI have been refined, although high-quality evidence remains limited in many areas. The aim of this...

Falciform flap suturing reduces seroma and drain duration in mastectomy±axillary dissection: a retrospective cohort study

Breast cancer represents the most common malignancy among women worldwide, with surgery serving as the primary treatment modality. Postoperative seroma constitutes one of the most frequent complications, with reported incidence rates ranging from 3% to 93% depending on the surgic...

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72 hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

ABSTRACT Atherosclerotic cardiovascular disease (ASCVD) remains the leading global cause of mortality, with substantial residual inflammatory risk persisting despite statin therapy. We identify a c‐Rel‐driven CD72 hi macrophage subset markedly enriched in human and murine atheros...