Guangzhou University of Chinese Medicine

Lateral internal sphincterotomy with skin grafting for chronic anal fissure: protocol of a multi-center randomized controlled trial

Abstract Background: Anal fissure, a prevalent anorectal disorder, is defined as a longitudinal tear in the anoderm distal to the dentate line.Chronicity develops in a substantial fraction of anal fissures despite initial conservative success, resulting in significant quality-of-...

Machine learning-based mapping of multimodal treatment allocations and prognostic implications of clinical concordance in non-small cell lung cancer

Machine learning models of non-small cell lung cancer (NSCLC) treatment usually examine one modality. We developed interpretable models of historical surgery, chemotherapy, and radiotherapy receipt in SEER. We assessed regional transportability and associations between observed t...

DUSP4 promotes anti-tumor CD8+ T cell function and boosts CAR-T cell efficacy in mouse colorectal cancer

The activation and function of CD8+ T cells, which are central for anti-tumor immunity, are tightly regulated by extracellular and intracellular signaling pathways. Dual-specificity phosphatases (DUSP), including DUSP4, dephosphorylate serine/threonine and tyrosine residues of pr...

YAP delactylation enhances therapy resistance in renal cell carcinoma

Abstract Lactylation is a novel lysine acylation modification, and its function and exact mechanisms remain unclear. The responsiveness to combined targeted and immunotherapy continues to be a major challenge in cancer treatment. Here, we discovered that lysine lactylation (Kla)...

Toeplitz-structured deep unfolding network for TomoSAR 3-D reconstruction

Urban area 3-D imaging is a key application of synthetic aperture radar (SAR). Classical compressive sensing-based tomographic SAR methods rely on iterative optimization, which is computationally expensive and sensitive to hyperparameter tuning, limiting its scalability for large...

Role of Life’s Essential 8 in the association of night shift work with cardiovascular disease and mortality: a prospective cohort study of UK Biobank participants

Background: Night shift work is linked to higher risks of cardiovascular disease (CVD) and mortality, but mechanisms remain unclear. Lifestyle, captured by the American Heart Association's Life's Essential 8 (LE8), may act as a modifiable mediator. We aimed to examine the associa...

Latent profile analysis of stigma and medical coping among patients with vaginitis: a cross-sectional study

Vaginitis is a common chronic condition among genital tract infections. Its sensitive anatomical location and tendency to recur not only impact individual health but also affect psychological well-being and coping strategies. This study aimed to identify latent profiles of stigma...

Mechanisms and therapeutic strategies of asthma: from bench to bedside

Asthma is a heterogeneous chronic airway disease arising from a complex interplay of genetic susceptibility and environmental exposures. Key pathobiological features include dysregulated immune responses (particularly type 2 inflammation), structural airway remodeling, and mucus...

An integrated bioinformatics analysis reveals that targeted activation of IL7R may reduce influenza A virus infection risk in patients with depression

Depression has been associated with increased susceptibility to influenza; however, the underlying mechanisms remain unclear. Mendelian randomization (MR) analysis was performed to assess the causal relationship between depression and influenza. Differential expression genes (DEG...

Association of methylenetetrahydrofolate reductase C677T polymorphism with lacunar infarction: A systematic review and meta-analysis

Background: The association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and lacunar infarction (LI) remains inconclusive. Methods: The literature retrieval encompassed PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, and Wa...

Oligodendrocyte Lineage Dysfunction in Alzheimer’s Disease: A Bidirectional, Stage-Dependent Account

Alzheimer’s disease (AD) has traditionally been framed as a neuronal disorder, yet white matter and myelin abnormalities are consistently detected in the preclinical period, before overt amyloid pathology or cognitive decline. This temporal relationship suggests that oligodendroc...

Alterations in Gut Microbiota and Serum Metabolome Are Associated with Postpartum Depression

Background: Postpartum depression (PPD) is a prevalent and debilitating disorder, with increasing evidence implicating the gut microbiota–brain axis. However, integrated alterations in gut microbiota and circulating metabolites in PPD remain insufficiently characterized. Methods:...

Ultra-high-performance liquid chromatography-quadrupole-orbitrap-tandem mass spectrometry identifies 24 “unexpected” compounds to construct a one-for-one anti -counterfeiting quality markers system of Lianhua Qingwen capsule

Abstract The study completed the quantification of 110 compounds from Lianhua Qingwen ( LHQW ) capsule using library-aided ultra-high-performance liquid chromatography-quadrupole-orbitrap-tandem mass spectrometry under three adducting models ([M − H] - , [M + HCOO] - , and [M + H...