Guangxi Medical University

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Serum albumin-creatinine ratio predicts sarcopenia and poor outcomes in patients with colorectal cancer

Abstract Background: This study was designed to explore the prognostic significance of the serum albumin-creatinine ratio (ACR) in patients with colorectal cancer (CRC). Methods: Kaplan-Meier survival analysis was utilized to evaluate overall survival (OS) and progression-free su...

Planned and unplanned repeat ERCP after endoscopic therapy for anastomotic biliary strictures following liver transplantation: a retrospective cohort study

Abstract Background Endoscopic retrograde cholangiopancreatography (ERCP) is the first-line treatment for post-liver transplantation anastomotic biliary strictures. However, repeat ERCP may represent either planned staged treatment or unexpected biliary deterioration. We evaluate...

NIR-II conjugated polymers for tumor sonodynamic therapy

Sonodynamic therapy (SDT) utilizes ultrasound to activate sonosensitive agents, generating reactive oxygen species (ROS) within tumor cells to induce oxidative damage. The advantages of ultrasound, such as deep tissue penetration, non-invasiveness, and spatial controllability, ma...

Vesicular trafficking in immune regulation and disease: from intracellular sorting to intercellular communication

Vesicular trafficking is a fundamental mechanism that maintains cellular homeostasis, enables precise material transport, and regulates signal transduction in eukaryotic cells. In immune cells, vesicular trafficking supports dynamic membrane remodeling and activation-dependent ve...

Oral Health Knowledge, Attitudes, and Practices among Pregnant Women in Routine Prenatal Care in South China: A Cross‐Sectional Survey

BACKGROUND: Physiological changes during pregnancy can increase the risk of oral diseases in women, which may directly affect the health status of their newborns. This cross-sectional study aims to assess the oral health knowledge, attitudes, and practices of pregnant women in So...

Epidemiological characteristics of hospitalized injury patients in a tertiary hospital of Guangxi Zhuang Autonomous Region, China: a retrospective single-center observational study

Abstract Background Injury is a substantial public health issue that ranks among the primary causes of mortality and disability globally. This study aimed to analyze the epidemiological characteristics and types of injury among hospitalized patients through a single-center hospit...

Exploration of acetylation-related biomarkers in osteoarthritis through bioinformatics analysis

Osteoarthritis (OA) is characterized as a chronic degenerative disorder affecting the joints. A growing body of evidence indicates that acetylation may play a role in the disease’s pathogenesis. However, the underlying molecular mechanisms remain largely undefined. The objective...

AKR7A3 rs1738023 association with susceptibility to female hepatocellular carcinoma and its role in AFB1 metabolism and tumor

Abstract Background Hepatocellular carcinoma (HCC) is one of the most common cancer worldwide. In this study, we performed a two-stage exome-chip association analysis and found that the aldo-keto reductase family7 member A3 (AKR7A3) rs1738023 may be a potential susceptibility loc...

Intratumoral and peritumoral CT radiomics-clinical feature fusion model for differentiating pulmonary tuberculosis and pulmonary cryptococcosis nodules

Abstract Objective To investigate the clinical value of a fusion model combining intratumoral and peritumoral CT radiomics features with clinical features for differentiating pulmonary tuberculosis (PTB) from pulmonary cryptococcosis (PC) nodules, and to develop a predictive tool...

Endoplasmic reticulum stress promotes ferroptosis in ventilator-induced lung injury by promoting HRD1-dependent GPX4 ubiquitination via the IRE1α/XBP1 pathway

Ventilator-induced lung injury (VILI) is a serious complication of mechanical ventilation. Endoplasmic reticulum stress (ERS) has been implicated in regulating ferroptosis, and we previously linked ERS to VILI-associated inflammation. However, how ERS mechanistically drives ferro...

Aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder in an adolescent with inflammatory polyarthritis and Sjögren-related features: a case report

Neuromyelitis optica spectrum disorder (NMOSD) is a severe immune-mediated astrocytopathy most commonly associated with aquaporin-4 immunoglobulin G (AQP4-IgG). Optic neuritis is a common phenotype in pediatric NMOSD, but diagnosis may be delayed when early magnetic resonance ima...

Air pollution-related proteomic signatures, molecular mediators, and AF-free life loss: A large-scale proteome-wide analysis

Background Air pollution is a major environmental risk factor for Atrial Fibrillation (AF). We aimed to derive robust, pollutant-specific proteomic signatures to elucidate the biological mechanisms and evaluate their potential risk-stratification utility. Methods We analyzed plas...

Accuracy of ultrasound in diagnosing anterior talofibular ligament injury: a meta-analysis

The anterior talofibular ligament (ATFL) is the most frequently injured structure of the ankle joint. This meta-analysis evaluates the diagnostic accuracy of ultrasound for anterior talofibular ligament injury. We systematically searched for PubMed, Embase, Web of Science, Scopus...

Achyranthes bidentata polysaccharides alleviate severe traumatic brain injury by suppressing the TLR4/MyD88/NF-κB pathway and inhibiting neutrophil extracellular trap formation

Objective This study aims to investigate the potential protective effects of Achyranthes bidentata polysaccharides (ABPS) against severe traumatic brain injury (sTBI) and to elucidate the underlying mechanisms. Methods A sTBI model was established using a modified free-fall impac...

Programmable ZBTB7A RNA N6-methyladenosine site-specific demethylation suppresses colorectal cancer liver metastasis

Colorectal cancer liver metastasis (CRLM) is the primary cause of CRC-related mortality, with inevitable chemoresistance to targeted therapies and immunotherapy. N 6 -methyladenosine (m 6 A), as a crucial epigenetic regulator of gene expression and cellular physiology, involved i...

Mechanism of Nitidine chloride against esophageal squamous carcinoma based on network pharmacology, molecular docking, and experimental validation

Nitidine chloride (NC) is a natural alkaloid that inhibits tumor proliferation and induces apoptosis in tumor cells. However, the role of NC in esophageal squamous cell carcinoma (ESCC) remains unclear. We aimed to explore the effects of NC on the proliferation, apoptosis, and mi...

Geriatric nutritional risk index and prognosis in middle-aged and elderly patients with nasopharyngeal carcinoma

To evaluate the prognostic value of the pretreatment Geriatric Nutritional Risk Index (GNRI) in middle-aged and older patients with nasopharyngeal carcinoma (NPC). This study included 235 patients with NPC aged ≥ 50 years. Patients were stratified into low GNRI (GNRI ≤ 98) and hi...

MiPEP133 enhances anti-tumor immunity in nasopharyngeal carcinoma by activating CD8 + T cells

Activation of the tumor immune microenvironment (TIME) is crucial for controlling nasopharyngeal carcinoma (NPC) progression. This study aims to identify miPEP133 as novel therapeutic targets for NPC treatment. RNA-Seq was used to assess miPEP133’s effect on NPC cells and T-cell-...

Osimertinib With or Without Chemotherapy in Advanced Non–Small Cell Lung Cancer With EGFR and Concurrent TP53 Mutations

Importance: Combination therapy has emerged as a promising therapeutic approach for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, its clinical benefit-risk profile remains a focus of ongoing debate. Identifying patients...