Guangxi Medical University

Genome-Wide DNA methylation profiling of tissue-plasma pairs identifies Novel cfDNA biomarkers for the diagnosis of gastric cancer

Screening for gastric cancer (GC) is critical for improving patient survival, yet current clinical methods suffer from invasiveness and limited sensitivity. The aim of this study is to develop a machine learning model for the non-invasive diagnosis of GC using the whole-genome me...

Augmented enhancement of valproate efficacy by taurine and pyridoxal phosphate via gabaergic metabolic support in epilepsy

A major clinical dilemma in epilepsy treatment lies in the difficulty of balancing efficacy and safety. First-line antiepileptic drugs such as valproic acid (VPA) exhibit dose-dependent side effects. Enhancing γ-aminobutyric acid (GABA)ergic inhibition is a core therapeutic strat...

Social networks, sleep quality, and nurses’ safety behavior: a mixed-methods study

Poor sleep quality and limited social resources are common among nurses and may compromise safety behavior, yet the pathways linking them remain unclear. This study explored the pathways through which nurses’ ego-network status and sleep quality are associated with safety behavio...

A MAM-targeted integrated atomic-precision MnSe janus nanozyme platform inhibits pyroptosis and ferroptosis for intervertebral disc degeneration therapy

Aberrant endoplasmic reticulum (ER)–mitochondria crosstalk at mitochondria-associated ER membranes (MAMs) drives oxidative stress, calcium dysregulation, pyroptosis, and ferroptosis in nucleus pulposus cells, accelerating intervertebral disc degeneration (IVDD). Nanozymes that mi...

Association Between Joint Effusion and Degenerative Osseous Changes of the Temporomandibular Joint: A Systematic Review and Meta‐Analysis

ABSTRACT Background Joint effusion (JE) on magnetic resonance imaging (MRI) has been proposed as a potential imaging marker of intra‐articular inflammation and degenerative involvement in temporomandibular disorders (TMDs). However, its association with temporomandibular joint de...

The impact of high-level pension insurance on the health of older men: evidence from the China Family Panel Studies (CFPS)

Population ageing has increased the importance of understanding whether higher-level pension arrangements contribute to older adults’ health. This study examines the association between high-level pension insurance and health outcomes among older men in China. Using data from the...

Self-buoyant cell-spheroid culture programming multi-spheroid assembly

Tempo-spatially controlled culture and assembly of cellular spheroids are fundamental in engineering tissue-like assembloids for scalable application, yet remain a technical challenge. Here, we show self-buoyant culture of cell spheroids and programmable assembly of multi-spheroi...

Theca cell monolayer co-culture improves oocyte in vitro maturation and subsequent embryo development in buffalo (Bubalus bubalis)

Theca cells (TCs) are essential regulators of both follicular development and regression, as they produce androgens that serve as precursors for granulosa cell aromatization. The present study aimed to examine the effects of TC monolayer co-culture on oocyte in vitro maturation (...

Exploring the relationship between gut microbiota and pan-cancer: a meta-analysis of Mendelian randomization studies

The relationship between the gut microbiota and cancer is of increasing interest, but remains incompletely understood. This study synthesized evidence from Mendelian randomization (MR) studies to assess the association between genetically predicted gut microbiota abundance and pa...

Research on development strategies for county-level traditional Chinese medicine services based on Grounded Theory

Abstract: This study aims to analyze the development of county-level Traditional Chinese Medicine (TCM) services in Guangxi based on grounded theory, providing theoretical support for proposing corresponding countermeasures to promote the development of TCM services in Guangxi co...

Effectiveness and Safety of Fixed‐Dose Combination Metformin and Empagliflozin in Type 2 Diabetes: A Prospective, Multicenter, Real‐World Study From China

BACKGROUND: This study assessed the real-world effectiveness and safety of a fixed-dose combination (FDC) of metformin and empagliflozin in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This prospective, multicenter, real-world study enrolled consecutive patient...

mTORC1 Activation Links Chronic Stress to Meso‐Circuit Desynchronization and Accelerated Amyloid Pathology via Autophagic Dysfunction

ABSTRACT Background Although depression is a potent risk factor for Alzheimer's disease (AD), the underlying causal mechanisms remain unclear. This study investigated the molecular and circuit‐level mechanisms linking chronic stress to accelerated AD pathogenesis and evaluated th...

Interpretable machine learning-based model for predicting postoperative urinary tract infection after minimally invasive surgery for upper urinary tract calculi: development and external validation

This study sought to develop and externally validate an interpretable machine learning–based model to predict the risk of urinary tract infection (UTI) following minimally invasive surgery (MIS) in patients with upper urinary tract calculi. Clinical data from patients suffering u...

Multi-pathway macrophage pyroptosis mediates necrotizing enterocolitis: integrated sequencing and animal validation

Abstract Background Necrotizing enterocolitis (NEC) is a life-threatening inflammatory disorder prevalent in preterm infants, yet its core pathogenic mechanism remains poorly defined. Pyroptosis is a proinflammatory programmed cell death closely linked to intestinal injury, but w...

Conserved SERPINE2 function maintains ovarian estrogen production to support fertility in goats and mice

Abstract Molecular relays bridging extracellular cues and intracellular steroidogenic enzymes in granulosa cells (GCs) during mammalian folliculogenesis remain poorly defined. Single‐nucleus RNA sequencing and functional profiling of goat ovaries with divergent litter sizes revea...

Machine-learning-based prediction of acute and late-onset skin reactions after neoadjuvant chemoradiotherapy for rectal cancer: a retrospective cohort study

Abstract To develop and validate machine learning models for predicting acute and late radiation-induced skin reactions in patients with locally advanced rectal cancer who received neoadjuvant chemoradiotherapy. This retrospective analysis included 358 patients with locally advan...

Escalating global burden of female infertility

This study explores the global burden of female infertility across 204 countries and 21 regions from 1990 to 2021. The population-based study analyzed was conducted using data from the Global Burden of Disease 2021. We assessed age-standardized prevalence rate (ASPR), age-standar...

Phenothiazine-Driven Autophagic Response in Macrophages as an Anti-cutaneous Tuberculosis Approach

Abstract Cutaneous tuberculosis (CTB), caused by Mycobacterium tuberculosis (Mtb) infection of the skin, remains a global health burden, underscoring the urgent need for more effective drugs and therapeutic strategies. In this study, we discovered a phenothiazine-based derivative...

Comprehensive pan-cancer analysis of DIMT1 reveals its prognostic significance and immune-associated characteristics with experimental validation in gastric cancer

Abstract Background Dimethyladenosine Transferase 1 (DIMT1) is an rRNA-modifying enzyme involved in ribosome biogenesis; however, its potential oncogenic relevance and immune-associated characteristics across human cancers remain incompletely understood. Here, we aimed to systema...

The lactate-to-albumin ratio for mortality risk stratification in sepsis-induced myocardial injury: a retrospective cohort study

Sepsis-induced myocardial injury (SIMI) is associated with a high fatality rate, yet specific prognostic indicators remain scarce. The lactate-to-albumin ratio (LAR), which integrates markers of tissue hypoperfusion and systemic inflammation, may offer valuable prognostic informa...