Guangxi Medical University

Monotropein mitigates atherosclerotic plaque vulnerability through circ_0140736/miR-495/SIRPα-mediated efferocytosis

Efferocytosis is a biological process in which phagocytic cells engulf and degrade senescent, damaged, or dead cells to prevent secondary necrosis and inflammation. This process is implicated in various diseases, including atherosclerosis (AS). Enhancing efferocytosis efficiency...

Nanozymes-on-a-Bubble with High Signal-to-Noise Ratio Peroxidase-like Activity for Colorimetric Sensing

Abstract Nanozyme-based colorimetric sensors have shown their immense potential in environmental monitoring and pharmaceutical quality control. However, achieving interference-free, high signal-to-noise ratio (SNR), and portable detection of the analyte using these sensors remain...

Scoparone protects against acetaminophen-induced acute liver injury: Insights from In vivo experiments and RNA sequencing

Background Scoparone (Sco) is known for its therapeutic effects in alleviating liver injury. This study aims to investigate the protective effects of Sco against acetaminophen-induced acute liver injury (ALI) and explore its underlying mechanisms through in vivo experiments and R...

Depression and anxiety mediate the association between sleep quality and health-related quality of life in people living with HIV

Sleep disturbances are highly prevalent among people living with HIV (PWH) and frequently co-occur with psychiatric comorbidities such as depression and anxiety. Although these factors independently predict health-related quality of life (HRQoL), the extent to which psychiatric s...

Altered EEG microstate dynamics and cortical structure-function associations in temporal lobe epilepsy with FBTCS

This study aimed to characterize alterations in electroencephalographic (EEG) microstate dynamics and their structural correlates in patients with temporal lobe epilepsy (TLE) with and without focal to bilateral tonic-clonic seizures (FBTCS). A total of 37 patients with TLE and a...

Association of C-reactive protein-triglycerides-glucose index-waist-to-height ratio with mortality in metabolic dysfunction-associated steatotic liver disease (MASLD): evidence from two cohort studies

Abstract Background MASLD significantly increases the risk of cardiovascular events and all-cause mortality (ACM). The impact of the C-reactive protein-triglyceride-glucose index (CTI) and its derivatives on mortality in the MASLD population remains unclear. This study aimed to i...

Metabolomics of immunosenescence: bridging blood biomarkers and metabolic pathways in aging

Immunosenescence—the progressive decline in immune competence with advancing age—contributes substantially to increased infection susceptibility, reduced vaccine efficacy, and heightened chronic inflammatory disease burden in older adults. Despite extensive characterization of im...

The marine drug plitidepsin alleviates osteoporosis in estrogen-deficient mice by suppressing ROS-mediated NRF2/HO-1 signaling and osteoclast formation

Abstract Marine-derived compounds represent an important source of innovative therapeutics owing to their structural diversity and broad bioactivity; however, their potential in osteoporosis therapy remains insufficiently explored. This study investigated the effects of plitideps...

Risk factors for frailty in older adults with cancer: a systematic review

Frailty and cancer interact bidirectionally and synergistically, exacerbating multiple adverse clinical outcomes in elderly patients. Accelerated global population aging has led to a continuous rise in the incidence of cancer among older adults, who inherently represent a high-ri...

Neuroticism increased risk of gastroesophageal reflux disease

Gastroesophageal reflux disease (GERD) is a common gastrointestinal disorder that severely reduces quality of life. Emerging data suggest that neuroticism, a personality trait associated with increased stress reactivity and sensitivity to physiological sensations, may contribute...

Development and validation of an intratumoral–peritumoral radiomics-clinical model for preoperative prediction of synchronous liver metastasis in pancreatic neuroendocrine tumors

Synchronous liver metastasis is an important prognostic factor in patients with pancreatic neuroendocrine tumors (PNETs). Imaging features of the primary tumor may provide information on metastatic propensity beyond direct assessment of the liver, but the contribution of the peri...

Missed deep ovarian pregnancy behind a ruptured corpus luteum: the value of postoperative β-hCG and methotrexate

Abstract Background Ovarian pregnancy accounts for only 0.5-3% of ectopic pregnancies. Its coexistence with a ruptured corpus luteum is exceptionally rare and creates a diagnostic challenge that can lead to incomplete treatment and persistent trophoblastic disease. Case presentat...

Characterisation of whole-blood extrachromosomal circular DNAs in Kawasaki disease complicated by coronary artery aneurysm

Abstract Background: Extrachromosomal circular DNAs are critical regulators of stress responses, immunity, and inflammation pathways. However, their role and underlying mechanisms in Kawasaki disease complicated by coronary artery aneurysm remain poorly understood. Methods: Whole...

Mechanosensitive epitranscriptomics in cancer: linking tumor mechanics, RNA modification, and immune escape

Solid tumors are mechanically abnormal ecosystems in which extracellular matrix stiffening, compressive stress, interstitial pressure, and aberrant fluid flow reshape cancer, stromal, and immune cell behavior. In parallel, the cancer epitranscriptome has emerged as a dynamic regu...

Impact of obstructive sleep apnea syndrome on serum and plasma S100B concentrations: a systematic review and meta-analysis of observational studies with experimental validation

Background Obstructive sleep apnea–hypopnea syndrome (OSAHS) is the most prevalent type of sleep apnea. S100B, an astrocyte-derived calcium-binding protein, has been reported to be associated with OSAHS, but the relationship between circulating S100B levels and OSAHS has not been...

Joint associations of comorbidity burden and polypharmacy with depressive symptoms, and joint effects of comorbidity burden, polypharmacy, and depressive symptoms on all-cause mortality among US adults aged 45 years and older: a dual cross-sectional and cohort study

Although comorbidity burden and polypharmacy are increasingly prevalent among middle-aged and older adults and may contribute to depressive symptoms, evidence on their joint associations remains scarce. Furthermore, the combined impact of comorbidity burden, polypharmacy, and dep...

The worth of diffusion-weighted imaging for quantifying liver iron concentration in transfusion-dependent thalassemia patients

Background Magnetic resonance imaging (MRI) is currently the primary method for evaluating liver iron concentration (LIC); however, most techniques necessitate intricate data post-processing. Consequently, the development of simple quantitative methods is highly desirable. Purpos...

Factors associated with blood flow velocity in the upper limb of cancer patients with peripherally inserted central catheters: a cross-sectional study

Abstract Background Peripherally inserted central catheters (PICC) are widely used in cancer care for long-term intravenous access, yet complications such as thrombosis remain a concern. Blood flow velocity is a key hemodynamic parameter closely associated with thrombosis risk. H...

Development and validation of a clinical prediction model for gastrointestinal hemorrhage in pediatric IgA vasculitis

To develop and internally validate a preliminary clinical prediction model for incident gastrointestinal hemorrhage (GH) occurring after admission in children with IgA vasculitis (IgAV), with continuous laboratory predictors retained in original scale to maximize predictive infor...

Sensitive Detection of Biomarker Using Multifunctional Aptamer-Modified Fluorescent E. coli O157:H7

Abstract Highly sensitive quantification of biomarkers is essential for disease diagnosis, treatment monitoring, and prognosis evaluation. Recently, nanomaterial-based immunosensors have attracted increasing attention due to their high sensitivity. However, the preparation of nan...