Guangxi Medical University

Endoplasmic reticulum stress promotes ferroptosis in ventilator-induced lung injury by promoting HRD1-dependent GPX4 ubiquitination via the IRE1α/XBP1 pathway

Ventilator-induced lung injury (VILI) is a serious complication of mechanical ventilation. Endoplasmic reticulum stress (ERS) has been implicated in regulating ferroptosis, and we previously linked ERS to VILI-associated inflammation. However, how ERS mechanistically drives ferro...

Aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder in an adolescent with inflammatory polyarthritis and Sjögren-related features: a case report

Neuromyelitis optica spectrum disorder (NMOSD) is a severe immune-mediated astrocytopathy most commonly associated with aquaporin-4 immunoglobulin G (AQP4-IgG). Optic neuritis is a common phenotype in pediatric NMOSD, but diagnosis may be delayed when early magnetic resonance ima...

Air pollution-related proteomic signatures, molecular mediators, and AF-free life loss: A large-scale proteome-wide analysis

Background Air pollution is a major environmental risk factor for Atrial Fibrillation (AF). We aimed to derive robust, pollutant-specific proteomic signatures to elucidate the biological mechanisms and evaluate their potential risk-stratification utility. Methods We analyzed plas...

Accuracy of ultrasound in diagnosing anterior talofibular ligament injury: a meta-analysis

The anterior talofibular ligament (ATFL) is the most frequently injured structure of the ankle joint. This meta-analysis evaluates the diagnostic accuracy of ultrasound for anterior talofibular ligament injury. We systematically searched for PubMed, Embase, Web of Science, Scopus...

Achyranthes bidentata polysaccharides alleviate severe traumatic brain injury by suppressing the TLR4/MyD88/NF-κB pathway and inhibiting neutrophil extracellular trap formation

Objective This study aims to investigate the potential protective effects of Achyranthes bidentata polysaccharides (ABPS) against severe traumatic brain injury (sTBI) and to elucidate the underlying mechanisms. Methods A sTBI model was established using a modified free-fall impac...

Programmable ZBTB7A RNA N6-methyladenosine site-specific demethylation suppresses colorectal cancer liver metastasis

Colorectal cancer liver metastasis (CRLM) is the primary cause of CRC-related mortality, with inevitable chemoresistance to targeted therapies and immunotherapy. N 6 -methyladenosine (m 6 A), as a crucial epigenetic regulator of gene expression and cellular physiology, involved i...

Mechanism of Nitidine chloride against esophageal squamous carcinoma based on network pharmacology, molecular docking, and experimental validation

Nitidine chloride (NC) is a natural alkaloid that inhibits tumor proliferation and induces apoptosis in tumor cells. However, the role of NC in esophageal squamous cell carcinoma (ESCC) remains unclear. We aimed to explore the effects of NC on the proliferation, apoptosis, and mi...

Geriatric nutritional risk index and prognosis in middle-aged and elderly patients with nasopharyngeal carcinoma

To evaluate the prognostic value of the pretreatment Geriatric Nutritional Risk Index (GNRI) in middle-aged and older patients with nasopharyngeal carcinoma (NPC). This study included 235 patients with NPC aged ≥ 50 years. Patients were stratified into low GNRI (GNRI ≤ 98) and hi...

MiPEP133 enhances anti-tumor immunity in nasopharyngeal carcinoma by activating CD8 + T cells

Activation of the tumor immune microenvironment (TIME) is crucial for controlling nasopharyngeal carcinoma (NPC) progression. This study aims to identify miPEP133 as novel therapeutic targets for NPC treatment. RNA-Seq was used to assess miPEP133’s effect on NPC cells and T-cell-...

Osimertinib With or Without Chemotherapy in Advanced Non–Small Cell Lung Cancer With EGFR and Concurrent TP53 Mutations

Importance: Combination therapy has emerged as a promising therapeutic approach for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, its clinical benefit-risk profile remains a focus of ongoing debate. Identifying patients...

Latent class analysis of sexual behavior and HIV testing profiles among sexually experienced college students in China: a cross-sectional online survey

Rising human immunodeficiency virus (HIV) infections among young people underscore the need to strengthen campus-based prevention. We used latent class analysis (LCA) to summarize sexual behavior and HIV-testing profiles among sexually experienced college students, examine associ...

A retrospective study on clinical and survival differences of head and neck versus other second primary malignancies in nasopharyngeal carcinoma survivors

Abstract Background Nasopharyngeal carcinoma (NPC) survivors face elevated risks of second primary malignancies (SPM); however, disparities between head and neck (HN-SPM) and non-head and neck (non-HN-SPM) are incompletely characterized. Methods This retrospective study analyzed...

Determining the minimal clinically important difference for EQ-5D-5L scores in patients undergoing primary total knee arthroplasty

Total Knee Arthroplasty (TKA) is a common procedure for knee osteoarthritis, but the Minimal Clinically Important Difference (MCID) for the EQ-5D-5L scale in TKA patients is not established. This study aims to determine the MCID for EQ-5D-5L in TKA patients. A prospective study w...

Mast cell–derived SPP1 promotes colorectal cancer liver metastasis by suppressing BTG1-mediated JUN degradation

The role of mast cells in colorectal cancer (CRC) liver metastasis remains controversial. This study aimed to explore the effect of mast cells on the CRC liver metastasis and the underlying mechanism. The bulk-seq, scRNA-seq datasets and clinical samples were integrated to identi...

Sensor-Based Movement Quality Assessment and Biofeedback for Rehabilitation Exercise: A Scoping Review with Implications for Home-Based and Remote Rehabilitation

Background/Objectives: Sensor-based movement assessment is increasingly used to quantify movement execution quality and support feedback-guided rehabilitation exercise, particularly in home-based and remote rehabilitation contexts. However, exercise adherence, movement execution...

Integrated Transcriptomic Profiling Reveals Candidate Genes for Huperzine A Biosynthesis in Huperzia serrata

Huperzine A (HupA) is a natural Lycopodium alkaloid known for its potent neuroprotective properties through the inhibition of acetylcholinesterase. Nevertheless, the limited understanding of its biosynthesis restricts its broader application. This study integrates full-length and...

Association of uric acid, lipid and bone metabolic markers with temporomandibular joint osteoarthritis: a cross-sectional study

Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease with a complex and multifaceted etiology. Although metabolic disturbances have been linked to osteoarthritis in other joints, their role in TMJOA remains unclear. This study aimed to investigate the associat...

Bioinformatics-based analysis of key genes associated with endoplasmic reticulum stress in myocardial infarction

Abstract Background Endoplasmic reticulum stress (ERS) is a critical pathological factor that drives myocardial infarction (MI) progression. This study aimed to screen and validate core ERS-related hub genes involved in acute myocardial infarction (AMI) pathogenesis by integratin...

6PPD-quinone disrupts the MARCHF2-EXOC7 ubiquitin axis to drive ferroptosis and redox imbalance in podocytes

levels, downregulation of GPX4, and accumulation of lipid peroxidation. A genome-wide CRISPR/Cas9 knockout screen identified EXOC7 as a critical mediator of 6PPD-Q-induced podocyte injury. Mechanistically, 6PPD-Q disrupted the E3 ubiquitin ligase activity of MARCHF2, leading to r...

Advances in collagen-based materials for tissue-engineered meniscus

Meniscus possesses weak self-repairability once getting hurt due to heterogeneity, particularly “white region” of avascular parts. However, the effect of conventional therapies in restoring structure and function of the meniscus isn’t ideal. Collagen, a key part of the extracellu...