First Affiliated Hospital Zhejiang University

G9a-mediated cholesterol metabolism triggers cuproptosis to promote alcohol-related liver disease

Abstract Whether and how disrupted cholesterol homeostasis contributes to alcohol-related liver disease (ALD) remains elusive. Here, we report that cholesterol biosynthesis is enhanced in ALD livers, driven by a reduction in the H3K9me2 epigenetic landscape orchestrated by the G9...

S1P-TREM2 axis protects immunosuppressive neutrophils from ferroptosis to promote tumour progression in hepatocellular carcinoma

Background Neutrophils are increasingly recognised as immunosuppressive drivers of hepatocellular carcinoma (HCC), yet their persistence in the oxidative, lipid-rich tumour microenvironment remains poorly understood. Objective To elucidate the metabolic and molecular programmes t...

SDF4 is a potential biomarker for diagnosis and severity assessment in patients with systemic lupus erythematosus

Abstract Background The implementation of refined management of systemic lupus erythematosus (SLE) poses a considerable challenge in clinical practice. In this study, we evaluated serum stromal cell-derived factor 4 (SDF4) as potential biomarkers for SLE diagnosis, disease severi...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

High immunosuppressants variability adversely affects post-transplant recurrence for patients with hepatocellular carcinoma

Tumor recurrence after liver transplantation (LT) for hepatocellular carcinoma (HCC) is the most significant obstacle impacting the prognosis of patients. Managing the clinical application of immunosuppressive agents is difficult, owing to their limited therapeutic range and nota...

Comprehensive evaluation of the αβ-TCR repertoire profile in hepatitis B vaccine-positive responders and patients with chronic hepatitis B

T cells play a vital role in hepatitis B virus (HBV) infection, mediating both protective immunity and immunopathology. Deep profiling of the T cell receptor (TCR) complementarity-determining region 3 (CDR3) provides critical insights into T cell composition and function. However...

cGAS–STING signaling in the anterior cingulate cortex modulates electroacupuncture analgesia in a rat neuropathic pain model

Background: The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway is associated with different neurological dysfunctions in the nervous system. Although electroacupuncture (EA) has been proven to alleviate neuropathic pain (NP), its underlyin...

Causal Effects of Lipoproteins and Lipids on Atrial Fibrillation: A Mendelian Randomization Study

ABSTRACT Background and AimsThe relationship between blood lipids and atrial fibrillation (AF) remains unclear. Nuclear magnetic resonance (NMR) spectroscopy enables the profiling of size‐defined lipoproteins and their contained lipid components. This study aimed to analyze the g...

PI3K/AKT signaling pathway: molecular crossroads in tumorigenesis and therapeutic innovation

The PI3K/AKT signaling pathway serves as a pivotal regulatory hub that governs essential cellular processes, including growth, proliferation, metabolism, survival, and migration. In the context of tumorigenesis and cancer development, aberrant activation of this pathway drives ma...

Longitudinal plasma phosphorylated tau217 classification and the association with Alzheimer's disease progression

Abstract INTRODUCTION Longitudinal diagnostic and prognostic validity of plasma phosphorylated tau217 (p‐tau217) in Alzheimer's disease (AD) remains uncertain. METHODS In this multi‐cohort study of 2117 individuals, we established baseline plasma p‐tau217 thresholds for amyloid‐β...

The effects of norepinephrine infusion combined with goal-directed fluid therapy on delayed graft function in patients undergoing kidney transplantations: study protocol for a multicenter randomized controlled trial

Chronic kidney disease presents a formidable challenge to global healthcare systems. With ongoing advancements in surgical techniques, kidney transplantation has emerged as a principal therapeutic modality for individuals afflicted with end-stage renal disease, markedly enhancing...

Effects of ketogenic diet on obesity indices, lipid profile, and glycemic control parameters in athletes: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials

The ketogenic diet has revealed more beneficial effects on metabolic health. However, its net effects on atherogenic lipoproteins, adiposity, and glycemic control remain inconsistent. This systematic review and meta-analysis aimed to quantify the pooled effects of the ketogenic d...

Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1-mediated cell-intrinsic resistance

SUMMARY While nucleoside DNA methyltransferase inhibitors (DNMTi) such as decitabine and azacitidine are effective in treating myelodysplatic syndrome (MDS)/leukemia, they have had limited utility for the majority of other cancers. Through a chemical library screen, we identified...

Mechanisms and Clinical Assessment of Fear of Disease Progression in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a progressive, life-limiting neurodegenerative disease characterized primarily by motor dysfunction, although cognitive and behavioral impairment occurs in a substantial subset of patients. Progressive functional decline and prognostic uncer...

A Pan‐Cancer Single‐Cell Atlas of Bone Metastases Reveals Convergent Malignant Programs and Coordinated Immune Dysfunction

ABSTRACT Bone metastases (BoMs) are a major clinical challenge across cancer types, yet mechanistic insights remain limited by small cohorts and insufficient profiling depth. Here, we present a single‐cell RNA sequencing atlas of 95 BoMs, 22 healthy bone marrows (hBMs) and 129 pr...

Astaxanthin supplementation and cardiometabolic risk factors in overweight and obese adults: a GRADE-assessed systematic review and meta-analysis

Astaxanthin, a marine-derived carotenoid, has shown antioxidant and anti-inflammatory properties in studies. However, its effects on cardiometabolic risk factors in overweight and obese populations remain inconclusive. Therefore, this systematic review and meta-analysis aimed to...

Strain-Tunable Altermagnetism in Bilayer PerovskitesMediated by Jahn–Teller Distortions

Abstract Altermagnetism, a novel collinear magnetic order distinct from conventional ferromagnetism and antiferromagnetism, has attracted great interest for its unique functional properties and potential applications in ultrafast spintronics. However, achieving effective control...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

Early oseltamivir initiation and influenza outcomes in kidney transplant recipients: a multicenter real-world study

Influenza infection poses a significant clinical threat to kidney transplant recipients due to their immunocompromised status. Although current guidelines recommend early antiviral therapy, real-world evidence supporting the effectiveness of oseltamivir, particularly regarding th...

Hepatocyte-intrinsic ER stress and NRF2 initiate primary sclerosing cholangitis, providing therapeutic insights

primary sclerosing cholangitis (PSC) is a severe liver disease that can progress to cholangiocarcinoma. Therapeutic development has been hindered by the rarity of PSC and by its poorly understood origin, which reflects incompletely defined genetic and environmental risk factors....