First Affiliated Hospital Zhejiang University

Supramolecular Salicylic Acid Chemical Peeling Combined with Supramolecular Active Zinc for Malassezia Folliculitis: Efficacy and Safety from a Multicenter, Single-Arm Trial

Traditional antifungal therapy for Malassezia folliculitis (MF) is often associated with high recurrence rates and limited long-term options. This study evaluated the efficacy and safety of 30% supramolecular salicylic acid (SSA) combined with supramolecular active zinc (SAZ) in...

A Narrative Review of Macrophage Plasticity in HIV-1 Persistence: From Tissue Reservoirs to Therapeutic Opportunities

Macrophages are key components of the innate immune system and play multifaceted roles in HIV-1 infection. Beyond serving as target cells for HIV-1, macrophages, particularly long-lived tissue-resident populations, are increasingly recognized as contributors to viral persistence...

A Macromolecule npEt20 Exerts Broad-Spectrum Synergistic Effects With Meropenem Against Multidrug-Resistant Gram-Negative Pathogens

Background: The widespread emergence of multidrug-resistant (MDR) Gram-negative bacteria severely compromises the clinical efficacy of carbapenem antibiotics, leading to refractory nosocomial infections. Novel antibacterial agents that can reverse carbapenem resistance are urgent...

Applications of the multi-process action control framework in physical activity promotion: a scoping review

The “intention-behavior gap” represents a core bottleneck in the failure of health behavior interventions, with traditional theories offering insufficient explanations for the dynamic mechanisms from intention formation to behavior maintenance. The Multi-Process Action Control (M...

Large-scale esophageal cancer screening through noncontrast computed tomography and artificial intelligence

The absence of accurate, noninvasive, scalable screening tools keeps early esophageal cancer (EC) detection a global health challenge. Although noncontrast computed tomography (NC CT) is widely accessible, the esophagus is a hollow tubular structure prone to collapse and motion a...

Kinesiophobia in chronic obstructive pulmonary disease: a scoping review

Kinesiophobia, an excessive and debilitating fear of movement, represents a significant yet under-recognized psychological barrier to engagement in pulmonary rehabilitation for people with chronic obstructive pulmonary disease (COPD). This scoping review aimed to map the existing...

Hepatocellular Carcinoma With a Grade 3 Neuroendocrine Tumor Component: A Case Report

Mixed hepatocellular carcinoma (HCC) and neuroendocrine tumor (NET) constitute an exceedingly rare and diagnostically challenging entity. We report a 70-year-old man with hepatitis C-related cirrhosis and multifocal HCCs, who was status post multiple microwave and radiofrequency...

A non-invasive diagnostic model for early detection of gastric and colorectal cancers using serum glycopeptide profiling and machine learning

Gastrointestinal cancers are leading causes of cancer-related mortality worldwide, with early detection significantly improving survival outcomes. However, current diagnostic methods are either invasive or lack sufficient sensitivity for early-stage disease. This study aimed to d...

A canonical role of SMAD4 in safeguarding 3D genome architecture to suppress lung tumorigenesis

Dysregulation of three-dimensional (3D) genome architecture is a hallmark of cancer, yet the mechanisms by which its disruption drives tumorigenesis remain incompletely understood. Here, we demonstrated that SMAD4 regulated 3D genome organization through its canonical transcripti...

Interpretable multimodal fusion of 18F-PSMA-1007 PET/CT and mpMRI for preoperative ISUP grade prediction in primary prostate cancer

Accurate preoperative International Society of Urological Pathology (ISUP) grading of prostate cancer (PCa) is critical for clinical decision-making. While multi-parametric MRI (mpMRI) is routine, it struggles with occult high-risk lesions due to limited metabolic insights. PET/C...

An expert-level generalist AI for abdominal CT diagnosis

Artificial intelligence (AI) in radiology aspires to deliver expert-level diagnosis across diverse clinical tasks, yet existing supervised strategies remain limited in scope. We developed RADAR, a generalist vision-language model trained on more than 400,000 contrast-enhanced abd...

Glycosides from Cistanche tubulosa suppress intestinal ACSL4-mediated ferroptosis to ameliorate depression with intestinal dysfunction symptoms through regulating arachidonic acid metabolism

Abstract Background Depression is highly comorbid with intestinal dysfunction, yet antidepressant therapies are limited by suboptimal efficacy and frequent gastrointestinal adverse effects. Existing cellular and animal data support the potentially dual protective effects of total...

User experiences and community responses to generative artificial intelligence health advice on reddit: topic modeling and content analysis study

Generative artificial intelligence (AI) chatbots are increasingly used for everyday health information seeking, yet little is known about how users interpret AI-generated health advice outside clinical encounters or how online communities respond when that advice is shared. This...

Single-cell transcriptomics landscape decodes cardiac fibroblast heterogeneity and reveals PDK4-driven profibrotic activation during cardiac fibrosis

Cardiac fibroblasts act as a key driver of myocardial fibrosis across various heart diseases, but the recently recognized heterogeneity within fibroblast populations has hindered mechanistic understanding. This study aimed to investigate the heterogeneity of cardiac fibroblasts a...

Clinical evaluation of deep learning-enhanced respiratory gated 18F-FDG PET/CT images

Abstract Objectives This study aims to comprehensively assess the value of deep learning (DL) models in improving the image quality of respiratory-gated PET/CT and explore the impact of PET acquisition time on the quality of model-predicted images. Methods We enrolled 90 patients...

MG53 suppresses IRF7 to reprogram macrophages and promote antitumor immunity in pancreatic ductal adenocarcinoma

In pancreatic ductal adenocarcinoma (PDAC), the desmoplastic stroma and immunosuppressive tumor microenvironment (TME) present barriers to immunotherapy. Here, we show that MG53 (TRIM72) is a critical regulator of macrophage fate and anti-tumor immunity; its myeloid-specific depl...

Development and validation of a knowledge, attitude, and practice questionnaire for management of metabolic complications after solid organ transplantation among medical staff

Metabolic diseases are common complications after solid organ transplantation (SOT) and significantly affect recipients’ quality of life and long-term survival. To our knowledge, no validated questionnaire specifically evaluates medical staff’s knowledge, attitude and practice (K...

Methyl indole-3-acetate contributes to strain-specific anti-inflammatory effects of Lactiplantibacillus plantarum

Lactiplantibacillus plantarum is a widely recognized probiotic with anti-inflammatory potential, yet its efficacy varies among strains and the underlying determinants remain poorly defined. Here, we identify methyl indole-3-acetate (MIA), a previously uncharacterized microbial me...

Association Between Lithium Use and Suicide‐Related Behaviors in Bipolar Disorder: A Multicenter Study

BACKGROUND: Lithium has long been associated with reduced suicide risk in bipolar disorder; however, evidence from real-world clinical populations remains susceptible to confounding, and the behavioral correlates related to this association are not well characterized. METHODS: In...

Deep learning CT signature for predicting early liver metastases in pancreatic ductal adenocarcinoma

Accurately predicting the risk of early liver metastases (ELM) and identifying patients who are most likely to benefit from neoadjuvant therapy (NAT) are critical for pancreatic ductal adenocarcinoma (PDAC). Here, we develop a Mamba-based predictive model that integrates imaging...