First Affiliated Hospital of Soochow University

Osimertinib With or Without Chemotherapy in Advanced Non–Small Cell Lung Cancer With EGFR and Concurrent TP53 Mutations

Importance: Combination therapy has emerged as a promising therapeutic approach for patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC). However, its clinical benefit-risk profile remains a focus of ongoing debate. Identifying patients...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...

Intranasal Delivery of Gallium–Quercetin Nanoparticles for Multi‐Target Ferroptosis Inhibition in Parkinson's Disease

ABSTRACT Ferroptosis contributes to Parkinson's disease (PD) through interconnected processes including iron dysregulation, oxidative stress, and mitochondrial dysfunction, yet current therapies targeting single pathways remain insufficient. Herein, we developed gallium–quercetin...

OMVs of Pseudomonas aeruginosa extracted from chronic suppurative otitis media trigger ototoxicity: possible relation to activation of NLRP3 inflammasome

Abstract Background Chronic suppurative otitis media (CSOM) can lead to sensorineural hearing loss (SNHL), but the underlying mechanisms remain incompletely understood. This study aimed to investigate whether the outer membrane vesicles (OMVs) from Pseudomonas aeruginosa ( P.aeru...