First Affiliated Hospital of Soochow University

Time-Dependent Prognostic Value of the sCD25-to-Ferritin Ratio in Chronic Active Epstein–Barr Virus-Associated Hemophagocytic Lymphohistiocytosis

INTRODUCTION: Chronic active Epstein-Barr virus infection (CAEBV) is an EBV-positive T/NK-cell lymphoproliferative disease characterized by persistent EBV infection in T or NK cells. CAEBV-HLH refers to hemophagocytic lymphohistiocytosis secondary to CAEBV. As important markers o...

Micro/Nanostructured Materials and Microfluidic Diagnostic Platforms Enable Multimodal Detection of Circulating Tumor Cells

ABSTRACT Circulating tumor cells (CTCs), as pivotal targets in liquid biopsy, offer dynamic, multidimensional insights into tumor heterogeneity and metastatic progression. However, their extreme rarity, pronounced heterogeneity, and the complexity of the blood microenvironment se...

Plasma Glutamine and Glutamate in Relation to Clinical Outcomes After Ischemic Stroke: A Multicenter Prospective Study

Background Glutamine (Gln) and glutamate (Glu) have been suggested to play a pivotal role in neuronal homeostasis and metabolic regulation, showing potential as prognostic biomarkers for stroke. This study aimed to evaluate the associations of plasma Gln, Glu, and glutamine‐to‐gl...

Claustrophobia Symptoms in Individuals Undergoing FDG-PET Imaging: Evidence-Based Implications for Nursing Management

Background Fluorodeoxyglucose positron emission tomography (FDG-PET) is an indispensable imaging modality within precision medical practice. Nevertheless, the enclosed scanner space often triggers claustrophobic distress in scanned patients. This cross-sectional research aimed to...

Correlation analysis between preoperative inflammation-nutrition-related indices and the risk of pancreatic fistula formation following distal pancreatectomy

Objective To investigate the associations of preoperative C-reactive protein-to-albumin ratio (CAR), inflammatory burden index (IBI), and C-reactive protein-albumin-lymphocyte (CALLY) index with clinically relevant postoperative pancreatic fistula (CR-POPF) after distal pancreate...

Comparative efficacy of exercise modalities for mild cognitive impairment in older adults: A network meta-analysis

Mild cognitive impairment (MCI) represents a critical window for dementia prevention, yet the comparative efficacy of diverse exercise modalities remains unclear. We conducted a frequentist network meta-analysis of 16 randomized controlled trials to identify the optimal exercise...

Sitagliptin for Acute Graft-Versus-Host Disease Prevention in Alternative Donor Transplantation: A Randomized Phase III Trial

PURPOSE This trial evaluated whether the addition of sitagliptin to antithymocyte globulin (ATG)–based prophylaxis reduces the incidence of acute graft-versus-host disease (aGVHD) after alternative donor hematopoietic stem-cell transplantation. METHODS This prospective, multicent...

Single-nucleus transcriptomics uncovers region-specific molecular features underlying selective aging vulnerability of cholinergic neurons

Cholinergic neurons exhibit functional and molecular heterogeneity across the basal forebrain (BF), midbrain (MB), and brainstem (BS), while the aging-associated transcriptional features remain poorly characterized. Here, we performed single nucleus RNA sequencing (snRNA-seq) on...

Epigenetic silencing of FCGR2A by promoter hypermethylation exacerbates cardiac remodeling in post-myocardial infarction heart failure

Post-myocardial infarction heart failure (post-MI HF) is among the cardiovascular diseases with the highest morbidity and mortality rates worldwide. However, the epigenetic landscape of post-MI HF remains incompletely characterized. Here reduced representation bisulfite sequencin...

Persistent Zn 2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn 2+ ‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

ABSTRACT Intervertebral disc degeneration (IVDD) is an age‐related disease accompanied by disrupted mitochondrial homeostasis and defective autophagy. Cellular senescence induces ion imbalance, which leads to mitochondrial damage and suppressed autophagic flux; nevertheless, the...

Asb2-KIF11 Axis Protects Against Heart Failure by Restoring Lysosomal Distribution and Mitochondrial Homeostasis

BACKGROUND: Heart failure remains a leading cause of mortality globally, driven by persistent mitochondrial dysfunction and maladaptive cardiac hypertrophy. Although impaired autophagic flux contributes to cardiac deterioration, the precise molecular mechanisms are still unclear....

Hospice care volunteers’ experiences of reflecting on life meaning: a descriptive phenomenological study

Hospice care volunteers are an important part of spiritual care in hospice settings. Through active listening and dialogue, they can help terminally ill patients rediscover and affirm the value of life and the meaning of existence that may have been obscured during illness. Howev...

Infrapopliteal runoff status predicts mid-term outcomes after endovascular popliteal artery aneurysm repair

This study aimed to evaluate mid-term outcomes after endovascular repair (EPAR) for popliteal artery aneurysms (PAAs), with a specific focus on identifying prognostic factors for adverse events after EPAR, particularly the impact of infrapopliteal runoff status. Open surgical rep...

Direct economic burden of nosocomial infection in cardiovascular surgery patients based on DRG payment management

Abstract Objective To investigate the characteristics and direct economic burden of nosocomial infections in cardiovascular surgery patients using Diagnosis-Related Groups (DRG) stratification. Methods Clinical data of cardiovascular surgery patients were collected from January 2...

Effect of phenylephrine versus ephedrine on the incidence of postoperative delirium in elderly patients undergoing non-cardiac and non-neurosurgical procedures: protocol for a multicentre, double-blind, randomized, controlled trial

BACKGROUND: Whether ephedrine, when used to maintain intraoperative blood pressure, is superior to phenylephrine in reducing postoperative delirium remains uncertain. This study aims to determine whether the intraoperative management of hypotension with ephedrine, compared with p...

Clinical significance of the mitral annulus-left atrium coupling index for predicting left atrial appendage thrombogenic milieu in patients with non-valvular atrial fibrillation

Left atrial appendage (LAA) function is governed by the structure and function of the left atrium (LA) and left ventricle (LV). The mitral annular–left atrial coupling index (MALACI) may provide incremental value for thrombogenic milieu risk stratification in non-valvular atrial...

Deciphering shared genetic architecture between migraine and intracranial aneurysm: an integrative genomic study of neurovascular comorbidity

Epidemiological studies have suggested an association between migraine and intracranial aneurysm (IA), but their shared genetic basis remains unclear. This study aimed to characterize the common genetic factors between the two disorders. Using genome-wide association study (GWAS)...

The abscopal effect and systemic immune reprogramming: from phenomenon to therapeutic design

The classical abscopal effect is defined here as objective regression of a verified non-irradiated tumor lesion following local radiotherapy. An immune abscopal phenomenon denotes a prespecified, reproducible immune change within such a lesion that is attributable to the local in...

An interpretable fecal microbiota-based GBM-SHAP machine-learning model for distinguishing ankylosing spondylitis from healthy controls

Previous studies have identified associations between ankylosing spondylitis (AS) and the gut microbiota. This retrospective secondary analysis aimed to develop and interpret a fecal microbiota-based machine-learning model for distinguishing AS samples from healthy-control sample...

SDF4 is a potential biomarker for diagnosis and severity assessment in patients with systemic lupus erythematosus

Abstract Background The implementation of refined management of systemic lupus erythematosus (SLE) poses a considerable challenge in clinical practice. In this study, we evaluated serum stromal cell-derived factor 4 (SDF4) as potential biomarkers for SLE diagnosis, disease severi...