First Affiliated Hospital of Soochow University

A fitness advantage from the pLVPK plasmid fuels the global spread of a carbapenem-resistant hypervirulent Klebsiella pneumoniae high-risk clone: ST11-KL64

BACKGROUND: The global emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP), particularly the ST11-KL64 subclone acquiring pLVPK-like virulence plasmids, represents a critical public health threat. This study investigates the epidemiological dominance a...

WTAP Transcriptional Suppression by KLF9 Drives Osteoclastogenesis via M 6 A‐Mediated Regulation of CSF1R Signaling in Estrogen‐Deficient Osteoporosis

ABSTRACT Osteoporosis, characterized by imbalanced bone homeostasis, is driven by excessive osteoclast‐mediated bone resorption, yet the epitranscriptomic regulation via m 6 A modification remains unclear. Here, we identify WTAP, a component of the m 6 A methyltransferase complex...

The role of lipid metabolism in immune thrombocytopenia: new perspectives from immune inflammation and thrombopoiesis

Abstract Background Primary immune thrombocytopenia (ITP) is an autoimmune condition defined by increased immune-driven platelet destruction and inadequate platelet generation. Emerging research highlights that global alterations in lipid metabolism are closely associated with im...

Chinese herbal medicine (Yiqi Huayu Jiedu Decoction) combined with chemotherapy for preventing postoperative recurrence and metastasis in elderly gastric cancer patients: protocol for a multicenter, double-blind, randomized, placebo-controlled trial

Abstract Introduction Gastric cancer (GC) has a generally unfavorable prognosis. Elderly patients often tolerate dual-drug chemotherapy poorly, experience limited benefits from monotherapy, and face high rates of postoperative recurrence and metastasis. To address this unmet clin...

Prediction models for intraoperative blood loss in spine surgery: a systematic review and methodological appraisal

Prediction models may support perioperative blood management in spine surgery, but their credibility depends on outcome definition, prediction time, calibration, validation, and transparent reporting rather than discrimination alone. We searched nine databases from inception to A...

Trajectories of Kinesiophobia and Influencing Factors in Patients With Acute Myocardial Infarction

It is widely acknowledged that kinesiophobia is prevalent among patients suffering from acute myocardial infarction (AMI). Although heightened kinesiophobia significantly predicts adverse outcomes, it should be recognized that this fear is dynamic and typically evolves during the...

Development and validation of a nomogram for predicting 28-day mortality in patients with severe community-acquired pneumonia

Severe community-acquired pneumonia (SCAP) progresses rapidly, is associated with poor prognosis. Early assessment and timely intervention are crucial for improving the short-term outcomes of patients this study aims to develop and validate a Nomogram prognostic prediction model...

UCHL1 Expression in Colorectal Cancer: Clinicopathological Significance, Prognostic Value, and Implications for Immunotherapy Response

Background/Objectives: Ubiquitin C-terminal hydrolase L1 (UCHL1) exhibits context-dependent roles in various cancers, but its clinical significance and biological functions specifically in colorectal cancer (CRC) remain incompletely understood. Methods: We systematically evaluate...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

DAMPs, PAMPs, and Alarmins: From Mechanism to Therapy

ABSTRACT Immune surveillance hinges on the precise regulation of molecular sentinels to maintain the equilibrium between physiological homeostasis and pathological distress. Central to this process is the sensing of exogenous pathogen‐associated molecular patterns (PAMPs) and end...

Laboratory aspirin resistance and the incidence of preeclampsia under prophylactic low-dose aspirin therapy: a systematic review and meta-analysis

A subset of pregnant women treated with prophylactic low-dose aspirin (LDA) still develop preeclampsia (PE), a severe pregnancy-related complication. It is hypothesized that laboratory aspirin resistance (LAR), which may undermine the preventive efficacy of LDA, is associated wit...

Integrative single-cell and machine-learning analysis identifies LGALS1 as a macrophage-associated diagnostic and prognostic biomarker in hepatocellular carcinoma

Background Hepatocellular carcinoma (HCC) is characterized by marked heterogeneity and an immunosuppressive microenvironment in which tumor-associated macrophages contribute to disease progression. This study aimed to identify macrophage-associated biomarkers with diagnostic, pro...

Early gastric carcinoma with lymphoid stroma associated with a low risk of lymph node metastasis and favorable prognosis: a multicenter study in a Chinese population

Abstract Objective Gastric carcinoma with lymphoid stroma is a rare subtype of gastric carcinoma. The clinicopathological features and prognosis of early gastric carcinoma with lymphoid stroma (EGCLS) remain elusive, especially in Chinese populations. Methods In this study, we in...

Drosha in mesangial cells regulates glomerular capillary tufts formation through drosha/ribosome/Gata3 axis

Abstract Drosha is a critical regulator of kidney development; its loss or mutation, identified in a subsets of Wilms tumor (WT), a pediatric kidney cancer, leads to nephric cap mesenchyme developmental defects. Here, we investigated the role of Drosha in mesangial cells and its...

Astaxanthin supplementation and cardiometabolic risk factors in overweight and obese adults: a GRADE-assessed systematic review and meta-analysis

Astaxanthin, a marine-derived carotenoid, has shown antioxidant and anti-inflammatory properties in studies. However, its effects on cardiometabolic risk factors in overweight and obese populations remain inconclusive. Therefore, this systematic review and meta-analysis aimed to...

Association Between Cognitively Stimulating Activities and Cognitive Function in Older Adults Living in Residential Care Homes

OBJECTIVE: To examine the relationship between cognitively stimulating activities and cognitive function among older adults in residential care homes. METHODS: A convenience sampling method was used to recruit older adults from three residential care homes in East China. Data wer...

Early oseltamivir initiation and influenza outcomes in kidney transplant recipients: a multicenter real-world study

Influenza infection poses a significant clinical threat to kidney transplant recipients due to their immunocompromised status. Although current guidelines recommend early antiviral therapy, real-world evidence supporting the effectiveness of oseltamivir, particularly regarding th...

Sirtuin 4 knockout exacerbates cardiac injury in septic cardiomyopathy via activating the MAPK-JNK pathway

Septic cardiomyopathy (SCM) significantly contributes to mortality among septic patients, and its mechanism is closely related to abnormal inflammatory responses. Previous studies revealed the essential role of the Sirtuin4 gene in cardiomyocyte and myocardial function; however,...

PD-L1+ exosomes as biomarkers and therapeutic targets in multiple myeloma: implications for CAR-T efficacy and combination immunotherapy

Although chimeric antigen receptor T-cell (CAR-T) therapy has reshaped the treatment landscape for relapsed/refractory multiple myeloma (RRMM), durable remission remains challenging. T-cell dysfunction and exhaustion are key obstacles to long-term efficacy. Programmed death-ligan...

Validation of [89Zr]Zr-oxine labelling and PET/CT imaging for tracking mesenchymal stem cells in mice and patients with perianal fistula

Allogeneic umbilical cord-derived mesenchymal stem cells (TH-SC01) hold promise for treating perianal fistulas (pf) in Crohn’s disease (pfCD); however, like other live-cell products, their in vivo behaviour remains unclear. Zirconium-89 ([ 89 Zr]Zr)-oxine positron emission tomogr...