Federico II University Hospital

Double functionalization in chitosan scaffolds for bone tissue engineering improvement

Abstract Chitosan is a natural polysaccharide produced by the deacetylation of chitin. It has been employed for several biomedical applications since it is biocompatible and biodegradable. In this work, two synthetic peptides were covalently grafted to chitosan to enhance cellula...

Global stability and uniform persistence in an epidemic model with saturating fomite-mediated transmission

Abstract We analyse the global dynamics of a Susceptible–Vaccinated–Exposed–Infected–Recovered (SVEIR) epidemic model with demographic turnover, imperfect vaccination, and two transmission routes: direct host-to-host contagion and indirect transmission via contaminated fomites. I...

Endoscopic and combined approaches in the surgical management of frontal and ethmoidal sinus osteomas: a novel decision-making flowchart

PURPOSE: Paranasal sinus osteomas are benign but potentially symptomatic lesions whose management remains heterogeneous despite recent advances. Choosing between a purely endoscopic or a combined approach can be challenging, particularly for larger lesions. This study aims to pre...

Does Gut-Endometrial Immunomodulation Promote Pregnancy in IVF Patients with Recurrent Implantation Failure and Chronic Endometritis Following Escherichia coli Nissle 1917?

Background: Recurrent implantation failure (RIF) remains one of the most challenging conditions in reproductive medicine. Although increasing evidence implicates chronic endometritis (CE) and alterations of the endometrial microbiota in impaired implantation, the potential contri...

Multimodal Assessment of Tissue Response After Thyroid Radiofrequency Ablation: Clinical, Imaging, Histopathological and Molecular Insights

Background: Ultrasound-guided radiofrequency ablation (RFA) has become an established minimally invasive treatment for selected benign and autonomously functioning thyroid nodules. Although clinical outcomes are well documented, the biological mechanisms underlying tissue remodel...

Regional brain metabolism and metabolic connectivity alterations in corticobasal syndrome assessed with [18F]FDG-PET

PURPOSE: F]FDG-PET) studies have described regional metabolic abnormalities but detailed subcortical and cerebellar structures involvement is less known and metabolic connectivity remains unexplored. This study combined voxel-based, region-of-interest (ROI) analyses and connectiv...