Federico II University Hospital

A new bio-enhanced iron formulation with improved iron bioaccessibility modulates intestinal pathways involved in iron uptake, storage and export

Abstract Iron deficiency remains a major global health concern, and the efficacy of oral iron supplementation is often limited by poor bioavailability and gastrointestinal intolerance. In this context, biofortified biological matrices may represent an alternative strategy to impr...

Electrochemical detection of gallic acid in commercial beverages empowered by the use of paper-based tool to collect and analyze

A simple and innovative paper-assisted electrochemical approach was developed for the determination and temporal monitoring of gallic acid in commercial beverages. The proposed platform combines low-cost screen-printed electrodes with wax-patterned paper discs, enabling the paper...

Addressing fusiform gyrus dysfunction in schizophrenia, theory of mind, and implications for antipsychotics’ response and resistance: A systematic review and critical appraisal

Background The Fusiform Gyrus (FG), a brain region relevant for the interaction between cognitive processes and emotional behavior, especially emotion recognition and interpretation of social cues, has been linked to the pathophysiology of schizophrenia conceptualized as a disord...

Design and analytical validation of Nexthyro 2.0, a custom next-generation sequencing panel integrating DNA mutation profiling and RNA fusion detection for routine thyroid pathology specimens

Abstract The increasing role of molecular testing in thyroid pathology, from the pre-operative stratification of indeterminate fine-needle aspiration (FNA) categories to the management of advanced carcinomas, has prompted the development of institution-specific custom NGS solutio...

The role of controllable household appliances for effective uptake of digital services by consumers and communities in the energy transition

Digitalisation is transforming modern energy systems into complex socio-technical ecosystems where interconnected devices, user practices and governance structures must be considered together. To analyse this landscape and address relevant research questions concerning controllab...

Identification and characterization of TrxA: a novel bacterial thioredoxin–metallothionein chimera

Abstract Heavy metals (HMs) are naturally occurring elements which can be essential, such as zinc, copper, and iron, or non-essential, including cadmium, mercury, and lead. While essential metals serve as cofactors in critical enzymatic processes, elevated concentrations of both...

Plasma proteomes of obesity and allometric body shapes in the EPIC cohort

Abstract General obesity (high body mass index, BMI) affects circulating proteins. Obesity-related outcomes, however, differ by body shape but waist and hip circumferences cannot distinguish abdominal from general obesity. We therefore used the allometric body shape index (ABSI),...

Bioprosthetic Valve Failure After Transcatheter Aortic Valve Replacement

BACKGROUND: Data on the long-term incidence and clinical impact of bioprosthetic valve failure (BVF) after transcatheter aortic valve replacement remain limited. This study aimed to assess the incidence, predictors, and clinical impact of BVF following transcatheter aortic valve...

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators

ABSTRACT Kv7 voltage‐gated potassium channels play a critical role in controlling electrical properties of excitable tissues. Neuronally‐expressed Kv7 channels are involved in both common and rare neuropsychiatric disorders, ranging from epilepsy to depression and neurodegenerati...

In vivo quantification of polyethylene wear in total ankle arthroplasty

Aims In vivo assessment of polyethylene (PE) wear in total ankle arthroplasty (TAA) relies on approximation using 2D metal interspace height (2D-MIH) loss on weightbearing radiographs. Weightbearing CT (WBCT), combined with distance mapping, may improve quantification of PE wear...

Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation

Lipidomics-guided screening of unexplored natural product chemical space provides access to small molecules that globally reprogram cellular lipid profiles. Here, we show that the meroterpenoid cyclosmenospongine from Spongia sp. reshapes immune cell lipidomes, shifting them from...

An Innervated Human Skin Equivalent that Electrically Encodes Mechanical and Thermal Stimuli

ABSTRACT Understanding how peripheral sensory circuits encode mechanical and thermal stimuli requires an experimental system that combines native tissue architecture with high‐resolution electrophysiological readouts. Existing innervated in vitro skin models typically rely on che...

From Structureto Dynamics: Activation Mechanism ofthe G Protein-Coupled Bile Acid Receptor 1-Gs Complex

Abstract The G protein-coupled bile acid receptor 1 (GPBAR1, also known as TGR5) is a key mediator of bile acid signaling, exerting its physiological effects through coupling with the stimulatory G protein (Gs). This interaction stabilizes the receptor’s active state and triggers...

Aphasia treatment research: a decision-making tool to guide the design of phased trials from the Collaboration of Aphasia Trialists (CATs) trials for aphasia panel

Background Systematic reviews of randomised controlled trials with meta-analyses indicate that speech and language therapy for aphasia after stroke is effective in improving communication. However, high-quality evidence to identify an intervention’s target population (who), regim...

Engineered PEA-producing Lactobacillus paracasei F19 prevents colitis-associated colorectal cancer in mice by modulating inflammatory–angiogenic signaling and beneficially reshapes gut microbiota composition

Colitis-associated colorectal cancer (CAC) arises from the interplay between chronic inflammation, epithelial dysregulation, angiogenesis, and microbiota alterations. Palmitoylethanolamide (PEA) is an endogenous lipid mediator with anti-inflammatory and anti-angiogenic properties...

Ultrasound-Guided Retroperitoneoscopic Lumbar Sympathetic Chain Selective Clamping with Indocyanine Green-Assisted Access: A Technical Note

Background: Primary plantar hyperhidrosis is a disabling condition characterized by excessive plantar sweating and impaired quality of life. Lumbar sympathectomy is reserved for patients with symptoms refractory to conservative treatment, but minimally invasive techniques remain...

Corporate Social Responsibility, Rural Development, and Demographic Sustainability in a Transition Economy

Retaining population is a core condition for the long-term sustainability of rural communities, yet rural out-migration is often treated merely as evidence of local development failure. Agriculturally productive regions may continue to lose population even when output, corporate...

Disentangling theFluorescence Origin in Flame-FormedCarbon Dots

Abstract Flame synthesis provides a sustainable and continuous route for producing carbon dots (CDs) with tunable photoluminescence; however, the fluorescence origin in flame-formed CDs remains poorly understood, limiting their rational design. In the present paper, we elucidate...

Therapeutic Music as a Neuroimmune–Metabolic Modulator in NAFLD: A Spleen‑Centered Working Hypothesis

Non-alcoholic fatty liver disease (NAFLD), recently renamed metabolic dysfunction-associated steatotic liver disease, is frequently accompanied by depression and chronic psychological stress that can worsen metabolic dysfunction, promoting NAFLD progression. Given the current lim...

A multi-phase reference matching algorithm for bibliometric analysis: design, implementation, and evaluation

Abstract Bibliometric analyses rely on accurate citation counts, yet bibliographic databases routinely contain variant representations of the same cited reference, differing in journal abbreviation style, author name format, punctuation, or metadata completeness, that fragment ci...