ETH Zurich

The future of high-dose, high-intensity neurorehabilitation: Consensus-based core recommendations from the fourth Stroke Recovery and Rehabilitation Roundtable

Objective: Convergent evidence indicates that high-dose, high-intensity rehabilitation (HDHI) improves outcomes beyond usual care after stroke, yet implementation remains limited. While questions of optimal dose, timing, and delivery format continue to be refined, the biological...

Multi-objective computational design optimization of a Total Disc Replacement implant

Abstract While cervical arthroplasty using Total Disc Replacement (TDR) implants is an established treatment for persistent neck and arm pain, revision rates limit it from reaching its full potential. To address the underlying complications, we developed finite element simulation...

Moisture-induced degradation of clay-bearing sandstone

Abstract Clay-bearing sandstones used in the construction of historic monuments, churches, and castles are highly susceptible to contour scaling, which manifests as fractures parallel to the exposed facades. Repeated wetting–drying cycles accelerate material degradation through s...

Tmem117, an oligodendrocyte-enriched regulator of NCX activity, links myelin homeostasis to counterregulation and metabolic health

Abstract The counterregulatory response (CRR) to hypoglycemia is a fundamental, evolutionarily conserved homeostatic mechanism orchestrated by the central nervous system (CNS) to ensure survival during glucose scarcity. In individuals with diabetes, this response is frequently im...

NEXUS Personalized Health, One platform to make your biomedical research possible

We are NEXUS Personalized Health at the ETH Zurich. Our friends call us NEXUS. We offer highly customizable services and collaborations in the field of biomedical research and development. A pool of professional scientists in bioinformatics, data science, statistics, software eng...

NEXUS Personalized Health, One platform to make your biomedical research possible

We are NEXUS Personalized Health at the ETH Zurich. Our friends call us NEXUS. We offer highly customizable services and collaborations in the field of biomedical research and development. A pool of professional scientists in bioinformatics, data science, statistics, software eng...

Dawn of the dinosaurs demonstrates early diversification bursts and a potential role for neutral dynamics during major evolutionary radiations

Abstract Major radiations have given rise to huge swathes of life on Earth, and understanding their dynamics reveals the process of biodiversity generation itself. The rise of dinosaurs and other archosaurs during the Triassic was a spectacular example of such a radiation; it set...

Potential glacier contributions to the 2024 La Bérarde flood

Abstract. On 20–21 June 2024, an unprecedented flood of the Etançons river caused important damage to the village of La Bérarde (Écrins, France). An analysis of the event showed that the flood was caused by the combination of an intense rain-on-snow event at high altitude and the...

Tracking funding disparities in global health aid with machine learning

Abstract Reducing the global burden of disease is crucial for improving health outcomes. However, misalignment between health aid and country-level disease burden leaves vulnerable populations without the necessary support for major health challenges, particularly in the least de...

Disentangling damage from operational variability: A label-free self-supervised representation learning framework for output-only structural damage identification

Damage identification is a core task in structural health monitoring. In practice, however, its reliability is often compromised by confounding non-damage effects, such as variations in excitation and environmental conditions, which can induce changes comparable to or larger than...

Coreless exoplanets induced by metal–silicate miscibility

The rocky interiors of exoplanets are generally expected to differentiate into a silicate mantle and a metallic core due to the immiscibility of metal and silicate under typical planetary formation conditions. Here, we use large-scale molecular dynamics simulations driven by mach...

Depletion of davemaoite in Earth’s ambient lower mantle

Abstract The mineralogy of the Earth’s lower mantle is fundamental to understanding the planet’s formation, composition, evolution, and dynamics. However, uncertainties in the elastic properties and phase transitions of CaSiO₃ davemaoite—the third most abundant phase in a pyrolit...

Using the Stressor-System-Resilience Resources-Outcomes (SSRO) scaffold to clarify the core components of resilience research in medicine

Abstract Modern medicine increasingly extends beyond treating disease to supporting individuals through recovery, adaptation, and long-term functioning, all central to the concept of resilience. Despite growing interest, resilience remains conceptually difficult to structure and...

Replication material for: Böhmelt, T., Ward, H., & Bernauer, T. (2025). Do welfare states have lower carbon emissions? The importance of state capacity in lower-income countries. Journal of Public Policy, 45(3), 428–448. doi:10.1017/S0143814X25000121

These files contain the replication materials for the paper: Böhmelt, T., Ward, H., & Bernauer, T. (2025). Do welfare states have lower carbon emissions? The importance of state capacity in lower-income countries. Journal of Public Policy, 45(3), 428–448. doi:10.1017/S0143814X250...

Replication material for: Böhmelt, T., & Bernauer, T. (2025). New evidence reveals curvilinear relationship between levels of democracy and deforestation. Research & Politics, 12(1), 20531680251320073. https://doi.org/10.1177/20531680251320073

These files contain the replication materials for the paper: Böhmelt, T., & Bernauer, T. (2025). New evidence reveals curvilinear relationship between levels of democracy and deforestation. Research & Politics, 12(1), 20531680251320073. https://doi.org/10.1177/20531680251320073

Replication material for: Böhmelt, T., Ward, H., & Bernauer, T. (2025). Do welfare states have lower carbon emissions? The importance of state capacity in lower-income countries. Journal of Public Policy, 45(3), 428–448. doi:10.1017/S0143814X25000121

These files contain the replication materials for the paper: Böhmelt, T., Ward, H., & Bernauer, T. (2025). Do welfare states have lower carbon emissions? The importance of state capacity in lower-income countries. Journal of Public Policy, 45(3), 428–448. doi:10.1017/S0143814X250...

Ryugu and Bennu preserve primordial isotopic heterogeneity absent from the meteorite record

Ivuna-type (CI) carbonaceous chondrites are commonly used as proxies for the composition of the planet-forming disk because their chemical abundances resemble those of the solar photosphere. However, their isotopic uniformity may reflect pervasive alteration and isotopic averagin...

Groundwater hysteresis increasingly decouples flowing network length from streamflow as snow shifts to rain

Abstract. Flowing stream networks expand and contract in response to dynamic groundwater levels. Field studies generally associate greater flowing network length (L) with higher streamflow (Q), but this neglects potential hysteresis caused by nonequilibrium groundwater flow after...

Teaching Signal Synchronization in Deep Neural Networks with Prospective Neurons

Abstract Working memory requires the brain to maintain information from the recent past to guide ongoing behavior. Neurons can contribute to this capacity by slowly integrating their inputs over time, creating persistent activity that outlasts the original stimulus. However, when...

COPI Coatomer Regulates Several Steps of HDL Metabolism

Abstract Background Reverse cholesterol transport by high density lipoproteins (HDL) is considered as an anti-atherogenic metabolic pathway. Hepatocytes determine the efficacy of this pathway by the production of apolipoprotein A-I (apoA-I) and its lipidation by ATP binding casse...