Erasmus University Rotterdam

The potential of [18F]FDG PET/MRI for identifying pain sources in patients with diagnostically challenging chronic hip pain after total hip replacement

Abstract Purpose Chronic hip pain after total hip replacement (THR) poses a diagnostic challenge and frequently yields lengthy and unsatisfactory diagnostic work-up. This study aims to evaluate the diagnostic role and clinical impact of [ 18 F]FDG PET/MRI compared with regular di...

Association between psychological frailty index and incident complete tooth loss among middle-aged and older adults: a prospective study based on CHARLS

Complete tooth loss is a severe oral health condition in middle-aged and older adults and is associated with impaired mastication, nutritional problems, reduced quality of life, and adverse ageing-related outcomes. Psychological frailty reflects multidimensional psychological vul...

New insights into statin-intolerance: biopsychosocial differences, medication beliefs, trust in healthcare and treatment decisions in statin-intolerant versus statin-tolerant patients.

AIMS: This study examined biopsychosocial differences between statin-intolerant and statin-tolerant patients, including their medication beliefs, healthcare trust and influential factors for treatment decisions. METHODS: A cross-sectional survey study was conducted among current...

Invasive and echocardiographic gradients of self- and balloon-expandable valves in failing aortic bioprostheses

Abstract Background Transcatheter aortic valve implantation (TAVI) is an established treatment for a failing aortic bioprosthesis. The hemodynamics of TAVI in degenerated transcatheter or surgical aortic valves (TAV-in-TAV or TAV-in-SAV) are unknown. We aimed to investigate hemod...

Health-related quality of life inequalities among patients with T2D in armed-conflict affected populations in Tigray, Northern Ethiopia

War causes tragic loss of life, destruction, and long-lasting quality-of-life distress in armed-conflict-affected populations. After conflict emerged between the federal government of Ethiopia and the Tigray regional government, the destruction of healthcare facilities and the bl...

Pendrin inhibitor PDSinh-C01 reverses salt-sensitive hypertension and metabolic acidosis in the 5/6 nephrectomy rat model

Abstract Pharmacological inhibition of the chloride-bicarbonate exchanger pendrin with PDSinh-C01 potentiates the diuretic action of furosemide in healthy mice. Because pendrin contributes to acid-base regulation and blood pressure control, it may represent an attractive therapeu...

“A beautiful chaos¨: a qualitative study on exploring the role of international communities of practice in knowledge translation for sexual and reproductive health and rights

Persistent knowledge-to-action gaps in sexual and reproductive health and rights (SRHR) limit the translation of evidence into policy and practice. Knowledge platform Share-Net International (SNI) uses Communities of Practice (CoPs) to support knowledge exchange, yet little is kn...

Redefining liver health: a multidimensional approach to preventing metabolic dysfunction-associated steatohepatitis

Metabolic dysfunction–associated steatohepatitis (MASH) is a rapidly escalating global health challenge driven by complex interactions among metabolic regulation, nutrition, immune signalling, gut microbiota, and environmental exposures. Current disease-centric frameworks priorit...

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...

Facilitating advance care planning in oncology: study protocol for the evaluation of a tailored implementation of an advance care planning tool (the INDEED study)

Abstract Background Advance care planning (ACP) improves patient outcomes, but integration of ACP in daily practice for patients with cancer in hospitals remains suboptimal. Systematic implementation of tools to facilitate ACP could overcome the barriers for ACP. In this study we...

From commitment to communication: a roadmap for strategic communication of corporate digital responsibility

Purpose This article introduces a theoretically grounded and practice-oriented roadmap to guide communication professionals in translating corporate digital responsibility (CDR) from organizational commitment into effective communication practice. It seeks to clarify CDR communic...

CPPAtools: a computation toolset for chimera protein prediction and analysis

Genetic or non-genetic frameshifting can increase the production of erroneous proteins, with far-reaching impacts on cellular phenotypes, including cancer. While the presence and impact of genetic alterations cannot be foreseen and are often defined clinically following phenotypi...

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re...

Durability of wrist denervation for osteoarthritis: a multicentre outcome study

INTRODUCTION: Traditional surgical treatments for wrist osteoarthritis, such as arthrodesis or arthroplasty, are invasive and irreversibly compromise joint motion. Wrist denervation offers a less invasive alternative aimed at pain relief while preserving mobility. However, its du...

The Effect of Antenatal Paracetamol on Breathing Effort of Premature Infants at Birth: A Feasibility Trial

Background: Prostaglandin E2 (PGE2) suppresses perinatal breathing. Reducing antenatal PGE2 concentrations with paracetamol could stimulate spontaneous breathing in premature infants at birth. We aimed to assess feasibility and potential effects of antenatal paracetamol. Methods:...

The Social Function of Property and Real Estate Abandonment: Between Property Law and Environmental Protection

Abstract This article explores the relationship between the social function of property and the abandonment of real estate, arguing that factual abandonment may amount to a form of ‘negligent non-use’ of property. Although the social function of property is both an external limit...

Management of high-risk (B3) breast lesions in symptomatic practice: evidence review and practical recommendations for multidisciplinary care

Borderline breast lesions (B3 lesions, also termed lesions of uncertain malignant potential or high-risk lesions) represent a heterogeneous group of entities associated with variable risks of malignancy. While the management of screen-detected B3 lesions has become increasingly s...

The Dutch cardiomyopathy registry (DCR); rationale and registry design

BACKGROUND: Cardiomyopathies are important causes of arrhythmias, sudden cardiac death, and heart failure. With accumulating knowledge in clinical, genetic, and molecular phenotyping, the number of distinct disease entities is growing. There is a need for broad, inclusive, high-q...

Concordance between plasma biomarkers of phosphorylated tau and tau-PET: A narrative review

Plasma phosphorylated tau (p-tau) and tau positron emission tomography (PET) are key biomarkers for detecting tau pathology in Alzheimer's disease (AD), offering both diagnostic and prognostic value. However, the concordance between plasma p-tau (p-tau217/p-tau181/p-tau231) posit...

Osteochondral Autograft Options for Reconstruction of Intra-articular Distal Humerus and Proximal Ulna Injuries in Physiologically Young Patients

Purpose Surgical options are limited for distal humerus and proximal ulna injuries with articular bone loss in physiologically young patients. Osteochondral grafts are a potential treatment option between open reduction internal fixation and arthroplasty that does not impart life...