Erasmus MC

Cullin 3 ubiquitin ligase regulates redox defense and metabolic programs in proximal tubule cells

Abstract Background Chronic kidney disease (CKD) is characterized by proximal tubule (PT) stress, oxidative injury, and metabolic dysfunction. Human kidney single-nucleus RNA-sequencing (snRNA-seq) identified enrichment of ubiquitin-dependent protein catabolic processes in injure...

Longitudinal analysis of the B-cell receptor repertoire across 30 years of ageing

Abstract Background The gradual decline in the functionality of the immune system during aging is commonly referred to as immunosenescence. This study aims to investigate changes in the B-cell receptor immunoglobulin heavy chain (BCR IGH) gene repertoire during natural aging and...

The Scolioscoop® V3: A low-tech self-assessment tool for patients with adolescent idiopathic scoliosis

Abstract Background Adolescent idiopathic scoliosis (AIS) requires follow-up during growth to detect progression, resulting in a burden of care. The Scolioscoop ® V3 was developed as an alternative to the Bunnell Scoliometer, to facilitate home monitoring by parents/caregivers. A...

Mapping spatial colleague connectivity patterns from individual-level registry data to inform regional pandemic interventions

A concern in infectious disease modelling is how accurately population mixing is incorporated, as it shapes the type and frequency of contacts through which infection spreads, and consequently, estimated intervention effectiveness. Although synthesizing mixing patterns from diary...

Purkinje cells in Crus I and II encode the visual stimulus and the impending choice as monkeys learn a reinforcement based visuomotor association task

Abstract Visuomotor association involves linking an arbitrary visual cue to a well-learned movement. Transient inactivation of Crus I/II impairs primates’ ability to learn new associations and delays motor responses without affecting the kinematics of the movement. The simple spi...

Oropouche virus causes severe congenital disease in embryonic mice

Abstract The recent outbreak of Oropouche virus (OROV) in Latin-America with unprecedented reports of vertical transmission resulting in congenital malformations and fetal death, redefines the threat posed by this arbovirus. We discovered that injection of a low inoculum of the e...

Integrated transcriptomic and proteomic analysis reveals innate and adaptive immune dynamics in systemic autoinflammatory diseases

Systemic autoinflammatory diseases (SAIDs) are a diverse group of rare disorders with partially overlapping clinical features. However, their genetic makeup and treatment responses vary widely. Although inflammasome dysregulation is central to many SAIDs, recent studies suggest t...

Aficamten for Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Nonobstructive hypertrophic cardiomyopathy (HCM) is a common condition that is associated with substantial morbidity and no proven medical therapy. Whether treatment with aficamten, a cardiac myosin inhibitor, can benefit patients with this condition is unknown. METHO...

A survey among geriatricians on geriatric oncology and geriatric surgical oncology models in Europe

Abstract Purpose To provide an up-to-date overview of geriatricians’ involvement in oncological and onco-surgical care for older adults across Europe. Methods An anonymous 35-item online survey was distributed via (inter)national societies between 10 April and 23 May 2025. The re...

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activatio...

Single bi-functional flexible sensor device for simultaneous pH and oxygen monitoring during pre-transplant normothermic perfusion

Monitoring of organ health and tissue damage through real-time sensing of chemical parameters such as pH and oxygen concentration could provide helpful information in the field of solid organ transplantation. Several sensors have been developed to detect oxygen concentrations and...

Comparison of Direct Oral Anticoagulants and Low-Molecular-Weight Heparins in Cancer Patients with Nonvalvular Atrial Fibrillation: Insights from a Single-Center Experience

BACKGROUND: Atrial fibrillation (AF) is frequently encountered in patients with cancer and poses challenges for anticoagulant management. The present study was conducted to compare clinical outcomes associated with direct oral anticoagulants (DOACs) and low-molecular-weight hepar...

Deep molecular profiling of lung neuroendocrine tumours and supra-carcinoids

BACKGROUND: Lung neuroendocrine tumours (NETs, also known as carcinoids) are rapidly rising in incidence worldwide but have unknown aetiology and limited therapeutic options beyond surgery. The current WHO classification, based on mitotic count and presence or absence of necrosis...

Development of a Photostable pH Biosensor Based on mStayGold

Fluorescent proteins (FPs) that are pH-sensitive play a crucial role in investigating pH-related cellular processes, such as endocytosis and exocytosis. Existing pH-sensitive FPs generated from Aequorea victoria green fluorescent protein (GFP), such as superecliptic pHluorin (SEP...

Deep learning aging marker from retinal images unveils sex-specific clinical and genetic signatures

Abstract Retinal fundus images offer a non-invasive window into systemic aging. Here, we fine-tune a foundation model (RETFound) to predict chronological age from color fundus images in 71,343 participants from the UK Biobank, achieving a mean absolute error of 2.85 years. The re...

Significant other reported outcome measures within European cohorts of severely injured patients: A systematic review

Abstract Purpose Major trauma can have a long-term impact, leading to diminished health-related quality of life (HRQoL) for patients and their significant others (SOs). Patient reported outcome measures (PROMs) make this impact visible, providing expectation- and self-management....

The potential of [18F]FDG PET/MRI for identifying pain sources in patients with diagnostically challenging chronic hip pain after total hip replacement

Abstract Purpose Chronic hip pain after total hip replacement (THR) poses a diagnostic challenge and frequently yields lengthy and unsatisfactory diagnostic work-up. This study aims to evaluate the diagnostic role and clinical impact of [ 18 F]FDG PET/MRI compared with regular di...

Factors for Success and Failure of Allergen Immunotherapy ( AIT ) Trial Design in the Light of Evidence‐Based Medicine: Current Aspects 2026

Allergen immunotherapy (AIT) has been acknowledged as the only disease-modifying treatment for respiratory diseases since its introduction in 1911. Although the efficacy and safety have convincingly been established in numerous randomized clinical trials (RCTs), the AIT study res...

Health-related quality of life inequalities among patients with T2D in armed-conflict affected populations in Tigray, Northern Ethiopia

War causes tragic loss of life, destruction, and long-lasting quality-of-life distress in armed-conflict-affected populations. After conflict emerged between the federal government of Ethiopia and the Tigray regional government, the destruction of healthcare facilities and the bl...

European S2k guidelines for hidradenitis suppurativa/acne inversa Part 1. Epidemiology, diagnosis and clinical assessment

BACKGROUND: This first part of the S2k guidelines is an update of the 2015 S1 European guidelines based on the structured assessment of clinically relevant topics by the panel of experts. It is complemented by Part 2, which deals with treatments. OBJECTIVES: These guidelines aim...