Erasmus MC

Early identification of individual, parent and family related factors associated with different levels of youth care services

Abstract Intensive youth care (out-of-home care and repeated outpatient care) is often provided to children with complex and persistent difficulties and is associated with adverse later outcomes. In order to reduce the escalation of care needs by timely referring to lighter forms...

Promotion of long-term health in early life

Noncommunicable chronic diseases (NCDs) are on the rise in high-income countries, leading to substantial morbidity and mortality and contributing to increased resource demands and healthcare costs. Early-life exposures can initiate trajectories that culminate in NCDs later in lif...

Associations of frailty and COVID-19 severity with long-term health outcomes of COVID-19 among older people

To investigate whether frailty and COVID-19 severity are associated with long-term health outcomes of COVID-19 in older people. In this cohort study, older people aged ≥ 70 years with COVID-19 between January 2020 and December 2021 were invited for follow-up. Participants were re...

Obesity, incretin-based therapies, and cardiovascular disease in women

Abstract Obesity in women is a growing and multifaceted public health challenge, driven by complex interactions among biological, hormonal, and psychosocial factors across the life course. From menarche to menopause, hormonal fluctuations influence fat distribution, energy balanc...

Effects of GLP-1 receptor agonists on body weight and cardiovascular outcomes: a review

Obesity is a rapidly increasing global health challenge that is strongly linked to the cardiorenometabolic syndrome, cardiovascular morbidity, and mortality. Lifestyle interventions remain the cornerstone of treatment, but average long-term weight loss is modest and durable weigh...

The Effect of BMI on the Image Quality of CTA Scans for DIEP Flap Breast Reconstruction

Background: Computed Tomography Angiography (CTA) imaging is currently the gold standard for the preoperative planning of deep inferior epigastric perforator (DIEP) flap breast reconstruction. Limited research has been performed on the effect of body mass index (BMI) on CTA image...

Disease progression in hidradenitis suppurativa: A multidimensional framework

Abstract Hidradenitis suppurativa (HS) is increasingly recognized as a progressive inflammatory disease in which recurrent follicular inflammation, tunnel formation and systemic inflammation drive cumulative, largely irreversible tissue damage, quality‐of‐life impairment and card...

Radium-223 decreases PD-L1 expression in bone metastases: A study with [89Zr]Zr-atezolizumab PET and immunohistological correlation

Abstract Purpose Most patients with metastatic castration-resistant prostate cancer (mCRPC) do not benefit from treatment with immune checkpoint inhibitors targeting programmed cell death (ligand) 1 (PD-(L)1). Radiation might improve response to immunotherapy by increasing the im...

Enabling Evolutionary Therapy in metastatic cancer lacking serum biomarkers

Evolutionary therapy (ET) aims to anticipate and steer tumor evolution by adjusting treatment timing and dosing, often to control rather than eradicate tumor burden. Clinical use requires reliable monitoring of tumor dynamics to inform mathematical models that guide therapy. In c...

Rehabilitation and the post-intensive care syndrome across the recovery continuum: a narrative review

Purpose Improved survival from critical illness has produced a growing population of intensive care unit (ICU) survivors with new or worsened physical, cognitive, and mental-health impairment, defined as post-intensive care syndrome (PICS), and frequent distress among families/ca...

Prenatal stress and gestational epigenetic age: no evidence of associations based on a large prospective multi-cohort study

Psychological stress during pregnancy is known to have a range of long-lasting negative consequences on the development and health of offspring. Here, we tested whether a measure of prenatal early-life stress was associated with a biomarker of physiological development at birth,...

Prevalence, clinical characteristics and treatment response of tremor in chronic inflammatory demyelinating polyneuropathy

Background Tremor can be a disabling symptom of chronic inflammatory demyelinating polyneuropathy (CIDP). Studies on tremor in CIDP are limited and generally include small populations. We aim to determine the prevalence, clinical characteristics and treatment response of tremor i...

Hip and groin pain in physically active adults with a focus on terminology, clinical examination and imaging: A formal ESSKA‐EHPA‐ESMA Consensus

Abstract Purpose This European Society of Sports Traumatology, Knee Surgery and Arthroscopy–European Hip Preservation Associates–European Sports Medicine Association (ESSKA‐EHPA‐ESMA) formal consensus aims to provide evidence‐ and expert opinion‐based recommendations for the term...

Quality standards for preclinical research in cardio-oncology

Preclinical research in cancer therapy-related cardiovascular toxicity (CTR-CVT) is a major domain of cardio-oncology and has provided biological explanation for the cardiovascular adverse effects of many cancer therapies. However, the choice of the experimental models to investi...

Low-Dose Naltrexone in Crohn’s Disease: A Prematurely Terminated Randomized Trial Showing Reduced Fatigue Without Clinical or Endoscopic Benefit

Crohn’s disease (CD) is often refractory to standard therapies, and patients are sometimes reluctant to initiate immunosuppressive therapy, prompting interest in novel treatments such as low-dose naltrexone (LDN). To evaluate the efficacy of LDN for induction of remission in pati...

Automated literature screening using large language models in headache research: a comparative performance evaluation of seven models using zero-shot and iterative prompt refinement

Abstract Background Large language models (LLMs) show promise for automating literature screening, although their performance varies across clinical domains and further evaluation is required for broader implementation. This study aimed to assess the accuracy, reliability and fea...

Experimental radiotherapy with the gastrin-releasing peptide receptor (GRPR) antagonist [177Lu]Lu-AU-SAR-M1 in a prostate cancer murine model using reduced-frequency dosing

The gastrin-releasing peptide receptor (GRPR) is highly expressed in prostate and breast cancers and hence serves as a legitimate target for radionuclide therapy (TRT). Radiolabeled GRPR antagonists are attractive radionuclide-carriers for TRT, due to their rapid tissue penetrati...

Morphology-Based Surgery for Chronic Pancreatitis Across Europe: Toward the Next Generation of Unified Guidelines

OBJECTIVE: To evaluate the use and impact of current surgical guidelines for chronic pancreatitis (CP) across Europe. SUMMARY BACKGROUND DATA: Current guidelines recommend morphology-based surgery for CP, but international studies evaluating their use and impact are lacking. METH...

Early Radiographic Changes Predict Radiographic Stability in Distal Radius Fractures: Development and Validation of an Explainable Predictive Model

Purpose To determine whether early radiographic trajectory data can predict the timing of stability in conservatively managed distal radius fractures (DRFs) and to identify which clinical and radiographic features most influence stabilization timing. Methods This retrospective co...

Prevalence of Acetabular Dysplasia in Early Adolescents From the General Population: A Generation R Study

Background: Acetabular dysplasia is an important risk factor for hip complaints and osteoarthritis in (young) adults. Early identification during childhood is important, as timely intervention may prevent irreversible joint damage. Although traditionally considered an infant-onse...