Erasmus MC

Real-time Quality Assessment of Donor Kidneys During Normothermic Machine Perfusion Using Perfusate and Urinary Biomarkers.

Background: Objective, real-time criteria for kidney graft quality during normothermic machine perfusion (NMP) are lacking, contributing to subjective acceptance decisions and organ discard. We evaluated real-time perfusate/urinary biomarkers and perfusion parameters during NMP a...

Predictive Value of Perfusate Cell-free DNA During Hypothermic and Normothermic Machine Perfusion of Donor Kidneys.

Background: Cell-free DNA (cfDNA) is a potential biomarker for graft (dys)function during machine perfusion, but its ability to predict posttransplant outcomes in donor kidneys remains unclear. Methods: We analyzed perfusate cfDNA from 57 hypothermic machine-perfused (HMP) and 56...

Radiologist and AI performance in detecting mucus plugs on chest CT

Abstract Objectives To compare automated mucus plug detection with radiologist evaluation, assess AI-assisted detection, and examine associations of algorithm-derived airway obstruction burden with COPD severity. Materials and methods This retrospective analysis included 278 COPD...

Living environmental quality and incident depressive symptoms among middle-aged and older adults in China: a national longitudinal study

Depressive symptoms are common in mid-to-late adulthood in China. Evidence linking living environments to depression has often focused on single exposures, and prospective evidence on the association between an integrated measure of living environmental quality (LEQ) and subseque...

Viral Tracing Gone Viral: Expanded Possibilities Call for Increased Caution in Describing Cerebellar Network Connections

This review discusses the huge expansion of using cleverly constructed neurotropic viruses and viral transgenes in neuroanatomical research, with a special focus on the cerebellar field. Thanks to the near-limitless possibilities these new tracing techniques offer, vital new info...

Urban–rural disparities in care deficit among functionally impaired older adults in China: prevalence gaps and shared determinants, 2013–2020

Global population aging highlights equitable elder care as a crucial challenge. China’s rapid aging amid a marked urban-rural divide offers a critical context to examine structural disparities in care deficits. This study aims to quantify urban-rural disparities in care-deficit p...

Bony trigeminal nerve entrapment in autosomal dominant osteopetrosis: a rare cause of secondary trigeminal neuralgia

Abstract Cranial bone disorders are a rare cause of secondary trigeminal neuralgia (TN), producing pain through progressive compression of the trigeminal nerve. We report a 46-year-old man with autosomal dominant osteopetrosis type 1 with left-sided refractory TN. Osteosclerosis...

Prehospital Stroke Treatment Trials in Conventional EMS Settings: An Expert Consensus Statement on Operational, Ethical, and Technological Priorities

Prehospital stroke trials enable assessments of ultraearly administration of treatments and management strategies, but face unique challenges in their design, conduct, and analysis. We outline important considerations and recommendations for planning prehospital stroke trials, fo...

Development of a monoclonal antibody targeting the calcification blocking factor CBF

Chronic kidney disease (CKD) patients suffer from a multitude of comorbidities, with vascular calcification being a major one. Recently, a new 19 amino acid long peptide, called calcification blocking factor (CBF), inhibiting vascular calcification has been identified. CBF concen...

Plasma indole-3-propionic acid is a gut-derived metabolite and is associated with type 2 diabetes and cardiometabolic outcomes: Evidence from a human antibiotic intervention

The gut microbiota influences host metabolism through diverse metabolites, many of which have been linked to glucose homeostasis and type 2 diabetes (T2D). Understanding microbial contributions to metabolite biosynthesis is essential for developing dietary and microbiota-targeted...

Evaluation of nationwide variation in post-haemorrhagic ventricular dilatation management following national guideline implementation in the Netherlands

Abstract Purpose Post-haemorrhagic ventricular dilatation (PHVD) is a severe complication of germinal matrix–intraventricular haemorrhage in preterm infants and is associated with significant morbidity and adverse neurodevelopmental outcomes. In 2023, national recommendations for...

Skill maintenance in neurosurgery: lessons from high-reliability professions and a plea to prioritize psychomotor skill retention, a mini-review

Microsurgical procedures in neurosurgery are characterized by steep learning curves, exceptional technical complexity, and limited tolerance for error. While considerable research has focused on microsurgical skill acquisition and the development of training models, substantially...

Weight management in cardiology practice: challenges and opportunities

Abstract Obesity poses a clear challenge to the cardiovascular landscape. In this viewpoint, we advocate that we need to prepare for the practical implementation of weight management in Dutch cardiology practice by 1) educating ourselves and our peers on obesity and its treatment...

Lobular cancerization in biopsy-diagnosed ductal carcinoma in situ (DCIS) of the breast: a detailed histopathological evaluation and reproducibility study

The role of lobular cancerization in ductal carcinoma in situ (DCIS) of the breast is poorly described to date. A precise definition is lacking. We explored the association between lobular cancerization in biopsy-diagnosed DCIS and different other histopathological features, as w...

W5. DNA METHYLATION AS PROXY OF GENETIC AND PRENATAL PSYCHIATRIC RISK FACTORS

Background Genetic and prenatal risk factors contribute to neurodevelopmental conditions (NDCs). DNA methylation at birth may integrate their combined effects. Methods By leveraging data from two longitudinal birth cohorts, Generation R (Ntrain = 1856, Ntest = 476) and ALSPAC (Nv...

Retinalysis-Vascx: An Explainable Software Toolbox for the Extraction of Retinal Vascular Biomarkers From Color Fundus Images

Purpose: Automatic extraction of retinal vascular biomarkers from color fundus images (CFIs) is crucial for large-scale studies of the retinal vasculature. We present VascX, an open-source software toolbox that extracts biomarkers from CFI artery-vein segmentations. Methods: From...

A multicenter randomized, double-blinded placebo-controlled phase 2 trial to evaluate safety and efficacy of ilofotase alfa in patients at risk for kidney injury following open heart surgery

Acute impairment of kidney function after cardiac surgery is common and associated with an increased morbidity and mortality. Ilofotase alfa has demonstrated potential to attenuate renal injury through its immunomodulatory effects. We evaluated the safety and efficacy of ilofotas...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

High rates of transition to immune active disease in a cohort of strictly defined immune tolerant patients with chronic hepatitis B: results from the RADICAL consortium

Background Patients with immune tolerant (IT) chronic hepatitis B (CHB) have high viral loads, minimal inflammation and minimal fibrosis. Nevertheless, the benign nature of this phase and the need for antiviral therapy remain controversial. Objective We explored the natural histo...

Do Androgens and Sex Hormone–Binding Globulin Mediate Sex Differences in the Risk of Stroke and Myocardial Infarction? The KORA Study

BACKGROUND: Sex differences in cardiovascular disease are well established, but the role of androgens and sex hormone-binding globulin (SHBG) remains unclear. We investigated whether these hormones and SHBG mediate sex differences in the risk of stroke and myocardial infarction (...