École Polytechnique Fédérale de Lausanne

Determinants of highly pathogenic avian influenza spread during bird migration

Abstract Migratory waterfowl are central to the global spread of the Goose/Guangdong lineage of H5 highly pathogenic avian influenza (HPAI), yet the parameters and processes shaping their role remain poorly understood, with evidence scattered across studies focused on narrow sets...

Mechanistic study of mixed lithium halides solid-state electrolytes

Lithium halides with the general formula LixMyX6}, where M indicates metal ions and X halide anions are very actively studied as solid-state electrolytes, because of relatively low cost, high stability and Li conductivity. The structure and properties of these halide-based solid...

A \({(2+\varepsilon )}\)-Approximation Algorithm for Metric \({k}\)-Median

Abstract. In the classical NP-hard (metric) [Formula: see text]-median problem, we are given a set of [Formula: see text] clients and centers with metric distances between them, along with an integer parameter [Formula: see text]. The objective is to select a subset of [Formula:...

Supporting upper limb movements with a soft robot after a brachial plexus injury

Brachial plexus injury causes severe arm weakness, forcing patients to rely on compensatory movements for daily activities. Most robotic solutions target isolated elbow or hand function, whereas multi-joint assistance remains limited. Here we show that a soft wearable exosuit pro...

Hierarchical Flux Competition Governs Electrochemical‐Chemical Coupling in Redox‐Mediated Batteries

ABSTRACT Redox‐mediated processes offer an effective strategy to accelerate sluggish kinetics and improve active‐material utilization across diverse battery chemistries. However, rational optimization remains challenging due to the lack of a quantitative framework describing the...

Multisoliton Solutions and Blow Up for the $$L^2$$-Critical Hartree Equation

Abstract We construct multisoliton solutions for the $$L^2$$ L 2 -critical Hartree equation with trajectories asymptotically obeying a many-body law for an inverse square potential. More precisely, we consider the m -body hyperbolic and parabolic non-trapped dynamics. The pseudo-...

Optimization of energy transition pathways in the lime industry: A superstructure approach

Lime manufacturing is a hard-to-abate industry, owing to high-temperature heat requirements and process-related CO 2 emissions from limestone calcination. Although numerous mitigation technologies have been proposed, existing studies generally evaluate individual options or rely...

Diketopyrrolopyrrole‐Based Cation as a Semiconducting Spacer in Layered Perovskite

ABSTRACT Incorporating π‐conjugated organic spacers in layered “2D” perovskites in order to extend solar light harvesting has remained a challenge, as typically‐incorporated spacers (e.g. phenethylammonium, PEA + ) do not absorb deep into the visible spectrum. Here, we introduce...

Poromechanical toughening in tensile fracture of saturated solids

<title>Abstract</title> Fracture in fluid-saturated porous solids is governed not only by solid mechanics but also by fluid flow within the pore space. In systems ranging from geomaterials to biological tissues, deformation in the near-tip region perturbs pore pressure and thereb...

Multicystic renal dysplasia with ureteral anomaly and arteritis in a C3-deficient mouse

/J (C3 knockout) mouse presented with abdominal distension and reduced general condition. The animal was euthanized and submitted for necropsy. Gross examination revealed marked dilation of the left kidney and ureter, both containing clear fluid consistent with urine and a focal...

Short mode-locked pulses from planarized Y-coupled THz lasers

Short THz pulses are highly attractive both for fundamental research and practical applications in this underdeveloped region of the electromagnetic spectrum. Typically, THz pulses are generated using nonlinear optical methods, starting from a high-power visible or near-IR mode-l...

Revisiting microplastic pollution: A novel method for detecting small-sized microplastics in natural waters

Abstract Microplastics are widespread, yet methods to measure polymer type simultaneously and particles size smaller than 20 µm are limited, hindering toxicity assessment and policy formulations. We introduce a machine learning-assisted spectral flow cytometry approach that ident...

Hydration-ControlledLayer Stacking in (NH3)2Cu5(SeO3)2(OH)6·(H2O)2+ x ( x = 0, 1, 3)

Abstract Hydration and dehydration are powerful yet underexplored variables for controlling the architecture of layered inorganic materials because intercalated water can modify interlayer separation, hydrogen-bonding networks, and layer stacking. Here, we report the reflux synth...

Aberrant cerebrovascular reactivity presents as an early biomarker of psychosis susceptibility in patients with 22q11.2DS

Abstract The brain’s ability to regulate blood flow is fundamental to both its function and development. In the context of neurodevelopmental disorders such as schizophrenia, understanding the complex interactions between cerebrovascular health and brain function is crucial for u...

COPI Coatomer Regulates Several Steps of HDL Metabolism

Abstract Background Reverse cholesterol transport by high density lipoproteins (HDL) is considered as an anti-atherogenic metabolic pathway. Hepatocytes determine the efficacy of this pathway by the production of apolipoprotein A-I (apoA-I) and its lipidation by ATP binding casse...

Robust out-of-distribution prediction of Buchwald–Hartwig reactions

Abstract The Buchwald–Hartwig cross-coupling is a cornerstone of modern pharmaceutical synthesis, yet predictive modeling of its outcomes remains constrained by data quality and chemical space coverage. Electronic laboratory notebooks contain heterogeneous, noisy records, while o...

Dyotropic Rearrangement of Hypervalent Iodine Species: Migrative Heterofunctionalization of Quaternary Carbons

ABSTRACT Phenonium intermediates are almost universally invoked to account for 1,2‐aryl migration processes in reactions that exploit in situ‐generated hypervalent iodine(III) leaving groups. Here, we demonstrate that such transformations can instead proceed through a previously...

Dyotropic Rearrangement of Hypervalent Iodine Species: Migrative Heterofunctionalization of Quaternary Carbons

ABSTRACT Phenonium intermediates are almost universally invoked to account for 1,2‐aryl migration processes in reactions that exploit in situ‐generated hypervalent iodine(III) leaving groups. Here, we demonstrate that such transformations can instead proceed through a previously...

Rational Molecular Design to Improve Digital Polymer Readout in Aerolysin‐Based Nanopore Sequencing

ABSTRACT Nanopore sequencing is a promising method for decoding synthetic digital polymers, but translocation signals are often complex. This study examines the influence of macromolecular design on the accuracy of nanopore sequencing. Nine phosphoramidite monomers were synthesiz...

Hydration-dependent exciton-phonon coupling in a metal-organic framework photocatalyst

Abstract Metal-organic frameworks (MOFs) have potential for light-harvesting applications owing to their tunable optoelectronic properties via building block selection. The presence of bound solvent in MOFs is known to impact gas adsorption properties, but little is known about t...