Dartmouth College

A phase II pilot trial of an indoleamine 2,3-dioxygenase-1 (IDO1) inhibitor (INCB024360) plus a multipeptide melanoma vaccine (MELITAC 12.1) in patients with advanced melanoma, with sequential evaluation of the tumor microenvironment

Indoleamine 2,3-dioxygenase-1 (IDO1) can mediate immune dysfunction by reducing tryptophan (Trp) and increasing kynurenine (Kyn). The CITN-04 clinical trial (NCT01961115) tested the safety and clinical activity of combination therapy with IDO1 inhibitor epacadostat (INCB024360) p...

Brain gray matter changes across chronic pain trajectories: MRI evidence from 35,000 individuals

ABSTRACT: Chronic pain affects brain gray matter structure, but the magnitude, pattern, and reversibility of brain changes upon pain recovery remain unclear because of inconsistent findings from small-scale studies. We analyzed data from 35,052 UK Biobank participants who complet...

Travel Time and Treatment Choice in Pelvic Organ Prolapse.

IMPORTANCE: Demographic shifts within the United States have led to an increased proportion of older adults living in rural areas, which brings additional challenges to accessing urogynecologic care. As a rural tertiary care center, we sought to explore how travel time affects a...

Seamful Design Considerations for Human-in-the-Loop Digital Phenotyping of Mental Health

Digital Phenotyping of Mental Health (DPMH) through passive sensing is a promising approach for personal health informatics and digital wellbeing. Its appeal lies in unobtrusiveness, making it appear seamless. However, this very quality leads users to find it impersonal, untrustw...

Decoupling band topology from criticality in bosonic systems

A new understanding of criticality in systems described by quadratic bosonic Hamiltonians (QBHs) ties the emergence of long-range correlations to boundaries of dynamical, not thermodynamical, stability in parameter space. This separation occurs because the solution of the Heisenb...

Trends in south pole particle concentrations imply holocene westerly wind strengthening

The Southern Hemisphere Westerly Winds (SHWW) play an important role in global climate and Antarctic ice sheet dynamics; however, high-resolution proxy reconstructions are sparse. Conflicting evidence suggests SHWW latitudinal change, weakening and/or strengthening, throughout th...

Equivalence of DNA-based cytometry to clinical flow cytometry and CBC for immune cell quantification in peripheral blood

Clinical flow cytometry, the current standard for immune cell typing and quantification, requires intact cell membranes, complex reagents, and substantial infrastructure, making it a costly, technically demanding process. In contrast, methylation cytometry only requires the measu...

Perceptions of inequality and group-specific public goods

We use data from a survey of 116,061 households in India to study beliefs about inequality. We uncover large differences between where individuals believe their household stands on the income distribution and their actual position. However, informing individuals that their househ...

Modeling psychological processes in tinnitus disorder: Comparison of quantitative methods

Tinnitus is a common experience, and a minority of people experience severe distress related to their tinnitus. Studies of the contribution of psychological factors are often small and replications are rare. Here we examined adults ( N = 125) with tinnitus distress who responded...

FELL BUNDLE LADDER

Abstract We use the ladder technique to establish bijections between the ideals of related Fell bundles.

On an n-ary generalization of the Lie representation and tree Specht modules

We continue our study, initiated in our prior work with Richard Stanley, of the representation of the symmetric group on the multilinear component of an n -ary generalization of the free Lie algebra known as the free Filippov n -algebra with k brackets. Our ultimate aim is to det...

A case for expanding access to minimally invasive and uterine-preserving surgery in complex fibroid disease

McMurray et al. (2026) recently published a retrospective analysis of 550 patients undergoing laparoscopic myomectomy for uterine fibroids at a single specialist centre. The authors found that pati...

Pots across the Pacific: Tracing Transnational Chinese Migrant Foodways from Guangdong to California

Abstract Migration involves not only the movement of people but also the circulation of ideas, capital, and material culture across space and time. In research about the Chinese diaspora, material continuity—especially the presence of objects from China—is often interpreted as ev...

Association between index adenomas and advanced neoplasia at third surveillance colonoscopy: Data from the New Hampshire Colonoscopy Registry

Background: Due to a lack of data, the USMTSF does not provide guidance for the 3 rd surveillance exam for adenomas detected on index colonoscopy. Our aim was to assess advanced outcome risk at 3 rd surveillance in patients with index adenomas. Methods: We included patients from...

Proteomics and characterization of lignocellulosic carbohydrate utilization for Thermoanaerobacterium thermosaccharolyticum reveals two thermophilic Gram-positive polysaccharide utilization loci

Saccharolytic bacteria are of increasing interest due to their importance in human health and the environment. In particular, their abilities to utilize diverse plant polysaccharides make them attractive candidate organisms for production of lignocellulosic biofuels. Thermoanaero...

Trafficked and Rescued: Travails of the Chinese “Slave Girl” in Progressive Era California

ABSTRACT This article examines the cultural and intellectual history of the Chinese “slave girl” in Progressive Era California. Joining a rich literature on how the movement of women across Europe and the Americas stoked cultural anxieties around sex work, gender norms, and “traf...

Inauthenticity from Transgressive Events: Situational Emotions and Generalized Distress

The affect control theory of self explains how interactions that challenge our core sense of self produce inauthenticity —a discrepancy between who we generally feel we are and how we feel about ourselves in specific events. However, the consequences of inauthenticity for emotion...

Building early career pathways in AI and medicine: a six-year pilot evaluation of the EDIT AI program

Artificial intelligence (AI) is rapidly reshaping biomedical research and clinical medicine, including cancer diagnostics, therapeutics, and healthcare delivery. Maximizing its translational impact will require a workforce capable not only of applying AI tools but also of underst...

Energy-Saving Low- and Medium Cavitation Temperature Deicer Theory and Experimental Testing

This manuscript presents the theory and experimental validation of low- and medium-temperature deicing technology that advances the recently developed Ice Cavitation Deicing (ICD) method. Conventional high-temperature ICD (HTICD) efficiently removes ice by explosively vaporizing...

Prenatal exposure to wildfire fine particulate matter and fetal growth outcomes in the United States: Findings from the ECHO Cohort

Background: Increasing exposure to wildfire fine particulate matter (PM 2.5 ) may pose unique risks to fetal development. We assessed associations between prenatal wildfire PM 2.5 exposure and fetal growth outcomes, including birth weight at term, birth weight for gestational age...