Chungnam National University

Age- and sex-adjusted genomic differences between Korean and Beat AML cohorts

Genomic profiling plays a central role in risk stratification and therapeutic decision-making in acute myeloid leukemia (AML), yet the clinical implications of population-specific genomic architectures remain incompletely defined. We conducted a prospective, multicenter study of...

Maternal dimethoxyethyl phthalate exposure enhances nicotine challenge-induced locomotor sensitization in adult male offspring rats: role of striatal dopamine D1 receptor

Early-life exposure to environmental endocrine disruptors, such as phthalates and bisphenol A, has been linked to neurobehavioral disorders, including autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD). Recent studies have also reported that individuals...

Human milk-derived Limosilactobacillus reuteri improved growth performance of weaned pigs by modulating systemic immune responses and enhancing intestinal health

This study aimed to evaluate the effects of dietary supplementation of human milk-derived Limosilactobacillus reuteri (REU) on growth performance, frequency of diarrhea, and systemic and intestinal health parameters of weaned pigs. Dietary supplementation of REU had greater (P =...

How Climate, Soil Conditions, and Biochar Characteristics Influence Crop Yield, Nitrogen and Phosphorus Fertilizer Productivity, and Economic Returns Across Cereals and Legumes: A Global Meta–Analysis

Biochar application is widely proposed to improve crop yield and fertilizer productivity, yet its performance varies across climatic, soil, and management contexts. This global meta–analysis study of about 705 database entries retrieved from 93 studies analyzed responses across c...

Towards a universal ovarian cancer biomarker model: clinical validation of Trx1 and CA125 dual strategy

Abstract Background Ovarian cancer is the fifth leading cause of cancer-related mortality in women, with early detection being critical for improving patient outcomes. Current diagnostic biomarkers, including Cancer antigen 125 (CA125), human epididymis protein 4 (HE4), and their...

Complementary vertebrate Wac models exhibit phenotypes relevant to DeSanto-Shinawi Syndrome

Monogenic syndromes are associated with neurodevelopmental changes that result in cognitive impairments and neurobehavioral phenotypes, including autism and seizures. Limited studies and resources are available to make meaningful headway into the underlying molecular mechanisms t...

Paired Whole-Genome Sequencing of Scalp Angiosarcoma and Matched Lung Metastasis Reveals Common Clonal Origin and Lung-Specific Evolution

Background and Clinical Significance: Cutaneous angiosarcoma frequently metastasizes to the lungs, where it may rarely present as diffuse cystic lung disease with recurrent pneumothorax, resulting in substantial diagnostic difficulty. We report a case of pulmonary metastatic cuta...

Korean Clinical Practice Guidelines for Rehabilitation in Critically Ill Patients and Post-Intensive Care Syndrome

Background: Survivors of critical illness commonly experience persistent physical, cognitive, and psychological impairments, collectively known as post–intensive care syndrome. Although intensive care unit (ICU) rehabilitation is now recognized as an important part of recovery af...

Double-outlet right ventricle with contrasting hemodynamic phenotypes in two dogs: two case reports

A double-outlet right ventricle (DORV) is defined as complete or predominant origin of both great arteries from the right ventricle and is almost always associated with a ventricular septal defect (VSD). Although DORV shows marked heterogeneity in humans, it is rare in veterinary...

Toward smart and adaptive apparel manufacturing: pattern-driven genetic algorithm optimization for modular garment assembly

Purpose This study proposes a pattern-driven genetic algorithm (GA)–based machine allocation framework for modular garment assembly systems to improve production efficiency, workload balance, and adaptability. Design/methodology/approach Seam-level information extracted from comp...

Nano- and Microplastic Release from Indoor Drinking Water Pipes: characteristics of different Pipe Materials

The current study comparatively evaluated the release characteristics of nano/microplastics and organic matter from non-metallic drinking water pipes. Accelerated aging experiments were conducted on polybutylene(PB) and impact-modified polyvinyl chloride(iPVC) to verify the effec...

Multimodal imaging diagnosis of concurrent left pulmonary arterial hypoplasia and right pulmonary arterial stenosis in a cat

A 10-month-old intact male British Shorthair cat weighing 4.1 kg was referred for evaluation of suspected heart disease, characterized by open-mouth respiration after physical activity. On physical examination, a grade 4/6 bilateral systolic murmur was auscultated. Thoracic radio...

Effect of intake air temperature on combustion characteristics and operation range of high-pressure ammonia direct injection engine

Ammonia is emerging as a promising carbon-free fuel, particularly for internal combustion engines, due to its high hydrogen content and potential for sustainable production. However, ammonia's low flame speed and narrow flammability limit pose challenges to combustion stability a...

Domain-Specific Cognitive Concordance in Older Married Couples

Importance Spousal similarity in late-life cognition has been reported, but whether concordance differs across cognitive domains remains unclear. Objective To examine whether cognitive concordance among older married couples is domain specific by comparing real couples with demog...

ODIN: Confirmation and 3D Reconstruction of Six Massive Protoclusters at Cosmic Noon

Abstract Protoclusters represent sites of accelerated galaxy formation and extreme astrophysical activity characteristic of dense environments. Identifying massive protoclusters and mapping their spatial structures are therefore crucial for understanding how large-scale environme...

Danburstotug, an anti‐ PD ‐ L1 antibody, in relapsed/refractory extra‐nodal natural killer/T‐cell lymphoma: The phase 2 DISTINKT study

Summary Relapsed/refractory extra‐nodal natural killer/T‐cell lymphoma (R/R ENKTL) has limited treatment options. Danburstotug, an antibody targeting programmed death‐ligand 1 (PD‐L1), was evaluated in adults with R/R ENKTL in a phase 2, open‐label study (NCT04414163). Danburstot...

From Sustainability Outcomes to Firm Value: Outcome Verifiability in Multi‐Tier Sustainable Supply Chains

ABSTRACT Sustainability investments in supply chains are positively associated with firm value on average, yet their effects remain heterogeneous. This paper argues that a critical and undertheorized source of this heterogeneity arises after environmental and social (E/S) outcome...

Surgical resection and angularis oris axial pattern flap reconstruction with adjuvant radiation therapy for recurrent soft palate leiomyosarcoma in a dog

Leiomyosarcoma of the oral cavity is extremely rare in both human and veterinary medicine. To the best of our knowledge, this is the first report describing the clinical course and multimodal treatment of a canine leiomyosarcoma arising in the soft palate. A 3-year-old, spayed fe...

Incidental Removal of an Aspirated Tooth During Routine Endotracheal Suctioning: A Case Report

Background/Objectives: Foreign body aspiration is a potentially life-threatening emergency that commonly requires bronchoscopic removal. Dental aspiration in elderly patients may occur following trauma, seizures, or altered mental status and can lead to airway obstruction and res...

Round robin test on polystyrene bead number concentration measurement using flow cytometry and commercial automated particle counters

Abstract Reliable particle counting is critical for applications such as clinical monitoring and cell therapy manufacturing. However, various particle counters using different measurement principles are employed, and the absence of reference materials makes standardization challe...