Chulalongkorn University

Discovery of Bis-ThioureaDerivatives as Human DNATopoisomerase IIα Inhibitors with Potent Anticancer Effects

Abstract DNA topoisomerase IIα (Topo IIα) is essential for maintaining genomic stability during DNA replication and mitosis and is highly expressed in cancer cells, making it a promising target for anticancer therapy. In this study, bis-thiourea derivatives were investigated for...

Wheat Flour Substitution with Sacha Inchi Tea Leaf Powder: Effects on Physicochemical Properties, Starch Digestibility, and Sensory Attributes of Cookies

Sacha inchi (Plukenetia volubilis L.) leaves are an underutilized by-product of an expanding oilseed crop, yet their use as a food ingredient remains limited. This study evaluated sacha inchi tea leaf powder (STLP) as a partial replacement for wheat flour in cookies at 0%, 2.5%,...

The Effect of Central Sensitization on Long‐Term Prognosis and Comorbidity Levels in Temporomandibular Disorders: A Prospective Longitudinal Study

ABSTRACT Background Temporomandibular disorders (TMD) have the potential to progress to a chronic form associated with various comorbidities. Prolonged symptoms may lead to central sensitization (CS), resulting in decreased treatment response and highlighting the need for persona...

Feasibility and Exploratory Outcomes of Foot‐Ankle and Walking Exercises for Diabetic Neuropathy, Stress, and Quality of Life: A Pilot Randomized Controlled Trial

Foot-ankle and walking exercises have been proposed as potential strategies for managing symptoms in people with diabetic peripheral neuropathy (DPN), yet evidence from primary care remains limited. This pilot study assessed the feasibility and acceptability of these intervention...

Role of Lewis centres on ethanol dehydrogenation over the Cu‐Cr/ γ ‐Al 2 O 3 system

Abstract A copper/chromium‐based catalytic formulation is evaluated for anaerobic ethanol dehydrogenation. Results indicate that the Cu–Cr interaction regulates dehydrogenation activity. This interaction increases the relative numbers of Lewis acid centres resulting in a superior...

Laboratory Concordance and Prognostic Impact of 10‐Color Flow Cytometry and Next‐Generation Sequencing‐Based Immunoglobulin Gene Assay for Measurable Residual Disease Monitoring in Adult B‐Cell Acute Lymphoblastic Leukemia: A Multicenter Study From Thai Acute Leukemia Working Group ( TALWG )

ABSTRACT Aims Measurable residual disease (MRD) is a key prognostic marker for patient survival. This study evaluated concordance between 10‐color flow cytometry and next‐generation sequencing (NGS)–based immunoglobulin heavy chain (IGH) gene assays for MRD detection and to asses...

Age-stratified probabilistic cancer and noncancer inhalation risks from volatile organic compounds near a major petrochemical complex in Rayong, Thailand

Abstract Background Communities residing near petrochemical complexes are chronically exposed to complex volatile organic compound (VOC) mixtures, but routine surveillance is often restricted to limited sentinel panels, which may lead to the underestimation of true health risks....

Element-SpecificSensitivity of Lanthanoid Ions toChiral Crystal Fields in K3[Ln2(NO3)9] Probed by 4f–4f Circular Dichroism

Abstract For chiral inorganic crystals composed of achiral components, chiral crystal fields around metal ions are expected to play a key role in the emergence of chiroptical properties. Circular dichroism (CD) spectra can serve as useful probes of such chiral crystal fields. Her...

Toward an Ecology of Deep Space Consciousness

Human spaceflight has been evaluated largely through physiological endurance and operational success. A more fundamental question has gone unasked: whether cognition remains viable when the environmental conditions that have always accompanied human life are radically altered. Th...

Direct composite injection molding with bilayered three-dimensional-printed clear index: a fully digital workflow case report of post-orthodontic anterior tooth wear

Background Recently, a new generation of high-strength flowable dental composites has been introduced by manufacturers.The manufacturers claim that these materials have enhanced mechanical and physical properties and are suitable for use in a wide range of direct anterior and pos...

Advanced functional biochar-based hybrid nanocomposites for electrochemical sensing platforms in environmental monitoring

Biochar (BC), a stable, carbon-rich material produced by heating biomass, is increasingly used in electrochemical sensing, particularly in hybrid nanocomposite forms, because hybridization can improve electrical conductivity, catalytic activity, surface area, and interfacial char...

Localization of feline gammaherpesvirus 1 in lymphoid tissues and pulmonary fibrotic lesions of naturally infected cats

Feline gammaherpesvirus 1 (FcaGHV1) is a recently identified member of the Gammaherpesvirinae detected in domestic cats; however, its tissue distribution and pathological relevance remain incompletely defined. This study investigated the localization of FcaGHV1 in naturally infec...

Phenotypic and Genomic Analysis of Swine-Derived Bacillus subtilis 1BP1Co1 as a Functional Probiotic Candidate to Mitigate Escherichia coli-Associated Diarrhea

Post-weaning diarrhea caused by pathogenic Escherichia coli is a significant economic challenge in global swine production. Rising antimicrobial resistance linked to traditional antibiotics necessitates safe, sustainable alternatives. This study isolated and characterized host-as...

The Shadow of Success: Rural Differentiation and the ‘Produced Poor’ in a Malawi Agricultural Development Project

ABSTRACT Smallholder agricultural projects are central to rural poverty reduction, yet their distributional outcomes remain underexplored. Using mixed methods (qualitative interviews and an 804‐household survey analysed via PSM‐DID), this paper examines a decade‐long Malawi proje...

Rural community revitalization through disaster tourism in Japan

The Great East Japan Earthquake and Tsunami (GEJET) in 2011 precipitated a profound socio-economic crisis in the Tohoku region, exacerbating pre-existing depopulation and aging trends. In response, the Japanese government’s “New Tohoku” initiative has prioritized rural community...

Podiatry for preventing falls in older people in the community

OBJECTIVES: This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of podiatry interventions for preventing falls in older people living in the community.

Multi-Targeted Neuroprotection by Areca catechu Against Cisplatin-Induced Neurotoxicity: Cellular, Caenorhabditis elegans, and Metabolomic Evidence

Cisplatin is an effective platinum-based chemotherapeutic agent used to treat a variety of cancers. However, its clinical utility is limited by dose-dependent neurotoxicity, yet no approved neuroprotective strategy currently exists. Our integrated cellular, metabolic, and in vivo...

The Impact of Plant-Derived Foods and Medicines on the Lung–Gut Axis and Microbiota Cross-Talk

The gut–lung axis is one of the bidirectional mucosal communication networks linking intestinal microbiota, microbial metabolites, immune regulation, and respiratory inflammation. This narrative review summarizes mechanistic and translational evidence identified through a structu...

Beyond Publication: Clinical and Translational Research under Pressure

Clinical and translational research (CTR) aims to move scientific knowledge into practice and improve health outcomes. This function is increasingly challenged by declining confidence in institutions, fragmented information environments, and changing roles of researchers in socie...

Lanolin in implantation of luminous polymer dots for environmental application as metal probes

Polymer dots (PDs) have become one of the potential fluorescent nanomaterials in environmental sensing because they are low-toxicity, tunable optical nanomaterials, and are cost-effective. Herein, a green and facile hydrothermal strategy was formed to nucleate luminous PDs with l...