Chinese PLA General Hospital

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

ABSTRACT Achieving efficient bone repair necessitates a thorough understanding of the physiological activities of native bone tissue, enabling selection and design of appropriate materials. To date, artificial scaffolds have been developed from inert materials to bioactive materi...

Structural lipidomics identifies murine plasma C=C location isomers for radiation dose stratification

Abstract Background Rapid and early radiation biodosimetry is essential for post-exposure medical triage and timely intervention. Owing to their high radiosensitivity, lipids are promising biodosimetry biomarkers. However, radiation-induced structural alterations, particularly ch...

Apical hypertrophic cardiomyopathy complicated by multisystem embolism, anticoagulant overdose-induced iliopsoas hematoma, and subsequent cardiocerebral infarction: a cautionary case report on DOAC dosing in renal impairment

Abstract Background Apical hypertrophic cardiomyopathy (ApHCM) is a morphological variant of hypertrophic cardiomyopathy characterized by relative apical hypertrophy (wall thickness ≥ 15 mm) with a relatively favourable prognosis. Approximately 30% of patients with ApHCM develop...

Machine Learning–Based Cytokine Endotyping of Thyroid Eye Disease

Purpose: Thyroid eye disease (TED) exhibits profound phenotypic heterogeneity that conventional binary thyrotropin receptor antibody fails to capture. We aimed to deconstruct this heterogeneity by establishing a cytokine-derived molecular taxonomy. Methods: We profiled 102 plasma...

Fluorination‐Driven Homogeneous Strategy for High‐Performance Tribo‐Piezoelectric Hybrid Nanogenerators

ABSTRACT Electrospun PVDF‐based tribo‐piezoelectric hybrid nanogenerators (TPHGs) exhibit potential in the domain of self‐powered sensing, owing to their high output performance and flexibility. However, simultaneously optimizing both piezoelectric and triboelectric outputs remai...

Merging artificial intelligence and retinal vascular geometric parameters: A novel tool for diagnosis and prognosis prediction of diabetic nephropathy

Abstract Background: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. The retinal microvasculature, as the only directly observable microvasculature, may reflect DN progression. This study aims to construct a non-invasive diagnostic and prognostic predic...

Twist Family BHLH Transcription Factor 1 orchestrates hypoxia-lactate crosstalk to bridge glycolytic flux and tubular maladaptation in fibrotic kidneys

Abstract The reprogramming of glycolytic metabolism is essential for maintaining the reparative homeostasis of tubular epithelial cells (TECs). Maladaptive TEC repair mechanisms drive the progression from acute kidney injury (AKI) to chronic kidney disease (CKD). Twist Family BHL...

Multicenter Privacy‐Preserving Federated Models for Predicting Postoperative Delirium and Acute Kidney Injury in Older Patients

ABSTRACT Postoperative delirium (POD) and acute kidney injury (AKI) are serious complications in older patients undergoing surgery, yet predictive model development is often constrained by single‐center data limitations and privacy concerns that preclude centralized data sharing....

Genetic predictive links between oropharyngeal microecology and obstructive sleep apnea syndrome: expanding the perspective of etiology

Background Obstructive sleep apnea syndrome (OSAS), a global public health concern, is linked to oropharyngeal microbiota, but observational studies cannot confirm their causal association.Objective To explore the potential causal relationship between oropharyngeal microecology a...

Exertional Rhabdomyolysis With Moderate Creatine Kinase Elevation and Marked Transaminase Elevation but Preserved Synthetic Function: A Case Report

Objective: Unusual clinical course Background:Rhabdomyolysis is a skeletal muscle injury syndrome characterized by release of intracellular contents into the circulation.Abnormal liver biochemical test results are commonly observed in severe rhabdomyolysis.Most published cases ha...

Subtype conversion and metastatic timing in breast cancer liver metastasis

Breast cancer liver metastasis (BCLM) represents a critical stage of disease progression and is associated with poor survival outcomes. Molecular subtype discordance between primary tumors and metastatic lesions has been increasingly recognized; however, the relationships among s...

Application of artificial intelligence-assisted ultrasound in the segmentation of splenic trauma

To develop an artificial intelligence(AI)-assisted ultrasound segmentation model for splenic trauma and to evaluate its clinical utility for trauma localization and contour delineation. (1) We assembled an animal ultrasound dataset comprising 4,280 images and a clinical dataset c...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...

Body composition, sarcopenia, and frailty among Northern seasonal migrant older adults: a cross-sectional study

Abstract Background To provide preliminary data on body composition, muscle health, nutritional status, and frailty among seasonal migrant older adults who overwinter in Hainan, and to identify potential health risks in this growing mobile aging population. Methods A cross-sectio...

Thermal ablation for benign thyroid diseases, low-risk thyroid carcinoma, and metastatic cervical lymph nodes: A Chinese multidisciplinary expert consensus (2025 edition)

The clinical role of thermal ablation in thyroid disease management has broadened substantially over the past decade as imaging guidance and minimally invasive technologies have advanced. Although thermal ablation is increasingly used in selected thyroid conditions, global practi...

PEG3 inhibits mitophagy of papillary thyroid carcinoma through ISG15/VCP axis

Abstract Interferon-stimulated gene 15 (ISG15) is an essential biomarker in several cancers. However, the molecular mechanism of ISG15 regulating thyroid carcinoma (THCA) has rarely been studied. In our study, papillary thyroid carcinoma cell lines of TPC-1 and IHH-4, clinical sa...

Safety, feasibility, and palliative benefit of HIFU combined with PD-1 inhibitors for elderly patients with advanced pancreatic cancer: a real-world retrospective study

BACKGROUND: Pancreatic cancer remains largely refractory to immune checkpoint inhibitors. High-intensity focused ultrasound (HIFU) may modulate the immunosuppressive tumor microenvironment via immunogenic cell death, yet clinical evidence on HIFU combined with programmed cell dea...

Fixation efficacy of a sliding cannulated screw system for unstable Pauwels type III femoral neck fractures: a finite element analysis, biomechanical investigation, and clinical study

Abstract Objective To compare the finite element performance, biomechanical properties, and short-term clinical outcomes of a novel Sliding Cannulated Screw System (SCSS) versus conventional Three Cannulated Screws (3CS) for unstable Pauwels type Ⅲ femoral neck fractures, and to...

Correlation between high-risk Human Papillomavirus (HPV) viral load and cervical lesions across different subtypes, along with the development of a clinical prediction model

Abstract Objective The study aims to investigate the correlation between the viral loads of HPV16/18 and 16 other high-risk HPV types (designated as non-16/18 group) and the severity of cervical lesions, and to develop a HSIL+ risk prediction model to furnish evidence for pragmat...

Tibial cortex transverse transport accelerates diabetic wound healing via systemic mobilization of non-classical monocytes

Aims: To clarify the immunomodulatory mechanisms by which tibial cortex transverse transport (TTT) accelerates wound healing in a type 2 diabetic rat model, with particular focus on the dynamics of subsets of monocytes and macrophages. Methods: A total of 186 male Sprague-Dawley...