Chinese PLA General Hospital

Triglyceride–glucose body roundness index and risks of incident cardiovascular disease and cardiometabolic multimorbidity: evidence from prospective cohorts in China and England

Cardiovascular disease (CVD) and cardiometabolic multimorbidity (CMM) impose substantial health burdens. The triglyceride–glucose body roundness index (TyG-BRI) integrates metabolic dysfunction reflected by TyG with body-shape information reflected by BRI, but its associations wi...

Topiramate use for maintenance antiseizure therapy in children with hematologic malignancies experiencing posterior reversible encephalopathy syndrome during chemotherapy: a single-center retrospective study

Seizures are a predominant symptom in posterior reversible encephalopathy syndrome (PRES) occurring in the context of chemotherapy. However, anti-seizure medications (ASMs) selection remains challenging due to potential pharmacokinetic interactions with chemotherapeutic agents. T...

BAP31 attenuates acute lung injury by inhibiting ferroptosis through activation of the AKT/GSK3β/Nrf2 pathway in the alveolar epithelial cells

Abstract Background: Ferroptosis plays an important role in the progression of lipopolysaccharide (LPS)-induced acute lung injury (ALI). Although B-cell receptor-associated protein 31 (BAP31) has been shown to mitigate lung inflammation and oxidative stress, its involvement in fe...

Frailty and bone quality as the predictors of mechanical complications for patients after lumbar interbody fusion: a retrospective cohort study

Mechanical complications following lumbar interbody fusion are common in in elderly patients, particularly those with compromised bone quality. The MRI-based vertebral bone quality (VBQ) score assesses bone quality, while the modified frailty index (mFI) captures systemic physiol...

Association between the serum glucose-to-potassium ratio and short-term mortality in critically ill patients with traumatic brain injury: a retrospective cohort study with exploratory machine-learning analysis

The serum glucose-to-potassium ratio (GPR) has emerged as a potentially informative biomarker in acute cardiovascular and cerebrovascular conditions, but its prognostic value in traumatic brain injury (TBI) remains insufficiently defined. We investigated the association between a...

Continuous glycemic phenotype derived from latent class mixed models predicts 28-day mortality after traumatic brain injury: a two-cohort study

Abstract Acute stress hyperglycemia is common after traumatic brain injury (TBI) and is associated with adverse outcomes. However, the prognostic value of longitudinal glucose trajectories during the early ICU stay remains poorly characterized, and whether post-TBI glycemic dynam...

From endovascular therapy to perivascular therapy: A new concept and perspective

The cardiovascular system relies on an organ-spanning vascular network not only for transport but also for systemic homeostatic control. Surrounding the vessel wall is a complex perivascular microenvironment, including the vasa vasorum, autonomic and sensory nerves, perivascular...

Diagnostic value of CEUS-VI-RADS for predicting muscle invasion in bladder cancer: Validation of the scoring system and introduction of tumor-bladder wall contact length as a supplementary quantitative metric

Purpose To validate the diagnostic performance of the Contrast-Enhanced Ultrasound-based Vesical Imaging-Reporting and Data System (CEUS-VI-RADS) and to explore the incremental value of the tumor-bladder wall contact length (TBCL) as a quantitative metric in predicting muscle inv...

Multiomics profiling identifies molecular and cellular signatures of regular exercise in human peripheral blood

Regular exercise is well established to protect against metabolic disorders and bolster immunity, but the underlying molecular and cellular mechanisms remain incompletely understood. We integrated plasma metabolomics and lipidomics with single-cell transcriptomic and chromatin ac...

PAFAH1B1 stabilization, through PUM2-mediated competitive binding with miRNAs on its’ 3’-UTR, takes active actions on ferroptosis to overcome the radioresistance to 125I radioactive particles of pancreatic ductal adenocarcinoma

Pancreatic cancer is one of the most fatal malignancies with the lowest 5-year survival worldwide. Radioresistance remains the major challenge for pancreatic cancer treatment. The aim of this study is to unravel the mechanism underlying PAFAH1B1-regulated radiosensitivity in panc...

FedBCFA: a boundary-constrained feature alignment federated learning framework for multi-center breast MRI classification

Multi-center medical image modeling faces persistent challenges arising from data privacy constraints and cross-institutional distribution discrepancies. Federated learning provides a feasible paradigm for collaborative training of intelligent diagnostic models for breast magneti...

Prognostic value of circ_0049271 in NSCLC and its regulatory effect on tumor

To explore the prognostic significance and functional role of circ_0049271 in non-small cell lung cancer (NSCLC). Clinical data were meticulously collected from 140 patients diagnosed with NSCLC. Lung cancer tissues, along with adjacent normal tissues, were preserved at -80 °C. A...

Regulating Electronic Coupling Channels via Dual‐Metal Sites in Two‐Dimensional Metal–Organic Framework Nanosheets for Ultrafast U(VI) Photoreduction

ABSTRACT Uranium removal from water is crucial, yet conventional photocatalysis is limited by carrier recombination and poor charge transfer. Herein, a dual‐site electronic coupling channel modulation strategy is proposed by tuning metal sites in both the porphyrin center and pad...

A study protocol of multicenter randomized controlled trial comparing three cannulated screws and dynamic condylar screw with medial anatomical buttress plate in treating old femoral neck fracture

Currently, there is no standardized consensus regarding hip preservation strategies for managing old femoral neck fractures. Our previously developed technique, utilizing a dynamic condylar screw (DCS), medial anatomical buttress plate (MABP), and iliac bone grafting (IBG), has b...

Early weight bearing with ultrasound monitoring is associated with accelerated functional recovery after open repair of acute achilles tendon rupture: a retrospective cohort study

Optimal rehabilitation after open repair of acute Achilles tendon rupture (AATR) remains controversial. Early weight-bearing may enhance recovery, but its clinical use is limited by lack of objective criteria. This study evaluated the safety and efficacy of an ultrasound-monitore...

Application of interpretable machine learning algorithms to predict diagnostic yield of radial probe endobronchial ultrasound transbronchial lung biopsy with guide sheath in peripheral pulmonary lesions

Abstract Radial probe endobronchial ultrasound transbronchial lung biopsy with guide sheath (RP-EBUS-GS-TBLB) was one of the main diagnostic methods for peripheral pulmonary lesions (PPLs). The aim of this study was to identify potential factors contributing to the diagnostic yie...

Phenotype evolution in post-COVID-19 chronic cough and prediction of pulmonary fibrosis risk: a longitudinal cohort study leveraging multi-omics integration and deep learning

Post-coronavirus disease 2019 (COVID-19) chronic cough (PCC) is a frequent sequela, affecting approximately 20–30% of patients beyond 8 weeks, with a subset progressing to pulmonary fibrosis (PF). Most existing studies rely on static indicators, which limits monitoring of dynamic...

Evaluation of FatNav‐Based Prospective Motion Correction for Perivascular Space Imaging With T2‐Weighted MRI at 7 T

ABSTRACT Subject motion during MRI acquisition is one of the major factors limiting image quality and diagnostic value. Previous studies have demonstrated the effectiveness of prospective motion correction (PMC) in mitigating motion‐related artifacts. However, the effectiveness o...

POU4F3 variants are prevalent in Chinese patients with autosomal dominant non-syndromic hearing loss and concurrent tinnitus

POU4F3 (DFNA15) is an established causative gene for autosomal dominant non-syndromic hearing loss (ADNSHL); however, its mutational spectrum in the Chinese population remains incompletely characterized. This study aimed to expand the mutational spectrum of POU4F3 in the Chinese...

Value of Thyroid Lymphatic Contrast-Enhanced Ultrasound in the Differential Diagnosis of Benign and Malignant Thyroid Nodules：A Prospective Single-Center Study.

<0.001）. Conclusions By revealing the lymphatic perfusion characteristics inside and around the nodules，LCEUS shows excellent efficacy in the differential diagnosis of benign and malignant thyroid nodules.LCEUS exhibits significantly better specificity and overall diagnostic ab...