Chinese PLA General Hospital

Noninvasive ultrashort wave neuromodulation enhances glymphatic clearance to alleviate traumatic brain edema and Alzheimer’s pathology

The glymphatic system clears cerebral waste, yet strategies to enhance its function remain elusive. Here, we show that 40.68 MHz ultrashort wave (USW) rapidly enhances glymphatic bulk flow in healthy mice within 10 minutes. USW potentiates both glymphatic influx and efflux, conco...

Therapeutic-scale CAR-NK microrobots with programmable swarm navigation for targeted solid tumor therapy

An urgent requirement in chimeric antigen receptor (CAR) immune cell therapy [e.g., CAR–natural killer (NK) cells] for solid tumors is to engineer the cells for precise tumor targeting. Meanwhile, medical microrobots can be navigated toward specific target sites using external ma...

Osteoporosis treatment via programmed delivery of IRF5 siRNA to macrophages in bone tissue combined with ROS scavenging

Postmenopausal osteoporosis (PO) is not merely a consequence of increased osteoclast activity. Estrogen deficiency induces oxidative stress and pro-inflammatory M1 macrophage polarization in bone tissue, thereby sustaining osteoclastogenic stimuli and pathological bone resorption...

QHHP Ameliorates MASH Through Modulation of a Cyp4a32–PPARγ–CD36‐Associated Lipotoxic Axis

Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive stage of metabolic dysfunction-associated fatty liver disease, for which effective pharmacological therapies remain limited. Qinggan Huatan Huoxue Prescription (QHHP) has been used clinically in the manageme...

Towards a structure-aware multi-hop retrieval framework for large language model reasoning over complex oncology guidelines

Large language models (LLMs) augmented with clinical guidelines show promise in medical question answering, yet structural parsing and evidence retrieval over complex guidelines remain challenging. We propose SMART-RAG (Structure-aware Multi-hop Augmented Retrieval Technique for...

CRISPR screening identifies TWIST1 as a ferroptosis driver in CKD progression

Chronic kidney disease (CKD) lacks effective therapeutic interventions targeting its fundamental pathological mechanisms. TWIST1 is a basic helix-loop-helix transcription factor that is a critical regulator in kidney fibrosis pathogenesis. We used genome-wide CRISPR-Cas9 screenin...

Mapping the global research landscape and emerging trends in tumor treating fields for cancer therapy

This study aims to map the structural landscape, collaborative networks, and thematic evolution of Tumor Treating Fields (TTFields) research via quantitative bibliometric analysis. By interpreting dataset structures rather than providing a traditional narrative review, it seeks t...

Natural Polysaccharides in Health and Targeting TGF-β/Smad Signaling Therapy in Chronic Diseases

Abstract Chronic diseases including cardiovascular disorders, cancers, diabetes and organ fibrosis are major global causes of mortality. The transforming growth factor-β (TGF-β)/suppressor of mothers against decapentaplegic (Smad) cascade governs key physiological events spanning...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

Concentrated growth factor in combination with insulin for improving type 2 diabetes mellitus alveolar bone regeneration: a pilot study

To compare the cumulative release concentrations of transforming growth factor-β1 (TGF-β1), bone morphogenetic protein-2 (BMP-2), insulin-like growth factor-1 (IGF-1) and insulin in concentrated growth factor (CGF) biomaterials derived from healthy and type 2 diabetes mellitus (T...

Timing of transurethral laser enucleation of the prostate after transperineal prostate biopsy: a multicenter cohort study

The optimal timing of transurethral laser enucleation of the prostate after transperineal prostate biopsy (TPB) remains uncertain. This study evaluated whether the interval between TPB and subsequent transurethral laser enucleation influences perioperative outcomes and postoperat...

Bile acid signaling in health and disease

Abstract Bile acids (BAs), cholesterol-derived amphipathic metabolites which are traditionally regarded as digestive surfactants, are now recognized as pleiotropic signaling molecules that act through ligand-, receptor-, and tissue-specific mechanisms to maintain systemic homeost...

Deep learning for predicting central cervical lymph node metastasis of papillary thyroid carcinomas deemed appropriate for active surveillance: a dual-center retrospective study

To develop and validate a two-stage two-path deep learning network (TTN) for automated nodule segmentation and prediction of central cervical lymph node metastasis (CLNM) in patients with small papillary thyroid carcinoma (PTC) eligible for active surveillance (AS) using ultrasou...

Dual Compartmentalization of GSTA4 Suppresses Ferroptosis to Drive Antiandrogen Resistance in Prostate Cancer

ABSTRACT Resistance to second‐generation antiandrogens poses a major therapeutic challenge in castration‐resistant prostate cancer (CRPC). While ferroptosis evasion has been implicated in treatment failure, the key molecular determinants driving this evasive process are poorly un...

Staged Lateral Lumbar Interbody Fusion Targeting Driver and Compensatory Structural Segments for Adult Degenerative Scoliosis: A Novel Strategy and Early Outcomes

OBJECTIVE: Traditional treatments for adult degenerative scoliosis (ADS) often rely on highly morbid long-segment fusions. While lateral lumbar interbody fusion (LLIF) provides a minimally invasive alternative, consensus on precise surgical targets is lacking. We propose a novel...

Metal-phenolic conducting polymer hydrogels for multifunctional cardiac patches and post-infarction myocardial repair

Myocardial infarction (MI) causes irreversible cardiomyocyte loss and adverse ventricular remodeling, yet current cardiac patches remain limited by inadequate bioactivity and poor electrical integration with host myocardium. We report a multifunctional metal–phenolic conducting p...

Comparative effectiveness of perioperative anticoagulation protocols on flap outcomes and immune-inflammatory profiles in oral squamous cell carcinoma reconstruction

Exploring the retrospective comparative effectiveness of different perioperative anticoagulation regimens on the survival rate, incidence of complications, and dynamic changes in systemic immune inflammatory markers after free flap reconstruction for oral squamous cell carcinoma...

Beyond statistical thresholds: Mapping sequential ATN cascade transitions via brain structural topography in Alzheimer’s disease

Alzheimer’s disease is widely conceptualized as a biological continuum initiated by amyloid-β (Aβ) accumulation, followed by tau aggregation and neurodegeneration. Although the ATN framework is commonly used to define disease stages, its static biomarker categories may not fully...

Fragmentomic features of cell-free DNA in human spent blastocyst medium and their potential for non-invasive embryo ploidy assessment

To characterize the fragmentomic features of cell-free DNA (cfDNA) in spent blastocyst medium (SBM) and their association with embryonic chromosomal status. One hundred fifty SBM samples were obtained from 43 preimplantation genetic testing for aneuploidy (PGT-A) cycles in 39 pat...

Global genomic epidemiology and antimicrobial resistance dynamics of Pasteurella multocida

Abstract Pasteurella multocida ( P. multocida ) is a crucial zoonotic pathogen, and its severe prevalence of antimicrobial resistance has attracted widespread attention in recent years. A global genomic analysis of 1,875 P. multocida isolates collected from 35 countries between 2...