Chinese PLA General Hospital

Multicenter Privacy‐Preserving Federated Models for Predicting Postoperative Delirium and Acute Kidney Injury in Older Patients

ABSTRACT Postoperative delirium (POD) and acute kidney injury (AKI) are serious complications in older patients undergoing surgery, yet predictive model development is often constrained by single‐center data limitations and privacy concerns that preclude centralized data sharing....

Genetic predictive links between oropharyngeal microecology and obstructive sleep apnea syndrome: expanding the perspective of etiology

Background Obstructive sleep apnea syndrome (OSAS), a global public health concern, is linked to oropharyngeal microbiota, but observational studies cannot confirm their causal association.Objective To explore the potential causal relationship between oropharyngeal microecology a...

Exertional Rhabdomyolysis With Moderate Creatine Kinase Elevation and Marked Transaminase Elevation but Preserved Synthetic Function: A Case Report

Objective: Unusual clinical course Background:Rhabdomyolysis is a skeletal muscle injury syndrome characterized by release of intracellular contents into the circulation.Abnormal liver biochemical test results are commonly observed in severe rhabdomyolysis.Most published cases ha...

Subtype conversion and metastatic timing in breast cancer liver metastasis

Breast cancer liver metastasis (BCLM) represents a critical stage of disease progression and is associated with poor survival outcomes. Molecular subtype discordance between primary tumors and metastatic lesions has been increasingly recognized; however, the relationships among s...

Application of artificial intelligence-assisted ultrasound in the segmentation of splenic trauma

To develop an artificial intelligence(AI)-assisted ultrasound segmentation model for splenic trauma and to evaluate its clinical utility for trauma localization and contour delineation. (1) We assembled an animal ultrasound dataset comprising 4,280 images and a clinical dataset c...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...

PEG3 inhibits mitophagy of papillary thyroid carcinoma through ISG15/VCP axis

Abstract Interferon-stimulated gene 15 (ISG15) is an essential biomarker in several cancers. However, the molecular mechanism of ISG15 regulating thyroid carcinoma (THCA) has rarely been studied. In our study, papillary thyroid carcinoma cell lines of TPC-1 and IHH-4, clinical sa...

Thermal ablation for benign thyroid diseases, low-risk thyroid carcinoma, and metastatic cervical lymph nodes: A Chinese multidisciplinary expert consensus (2025 edition)

The clinical role of thermal ablation in thyroid disease management has broadened substantially over the past decade as imaging guidance and minimally invasive technologies have advanced. Although thermal ablation is increasingly used in selected thyroid conditions, global practi...

Body composition, sarcopenia, and frailty among Northern seasonal migrant older adults: a cross-sectional study

Abstract Background To provide preliminary data on body composition, muscle health, nutritional status, and frailty among seasonal migrant older adults who overwinter in Hainan, and to identify potential health risks in this growing mobile aging population. Methods A cross-sectio...

Fixation efficacy of a sliding cannulated screw system for unstable Pauwels type III femoral neck fractures: a finite element analysis, biomechanical investigation, and clinical study

Abstract Objective To compare the finite element performance, biomechanical properties, and short-term clinical outcomes of a novel Sliding Cannulated Screw System (SCSS) versus conventional Three Cannulated Screws (3CS) for unstable Pauwels type Ⅲ femoral neck fractures, and to...

Safety, feasibility, and palliative benefit of HIFU combined with PD-1 inhibitors for elderly patients with advanced pancreatic cancer: a real-world retrospective study

BACKGROUND: Pancreatic cancer remains largely refractory to immune checkpoint inhibitors. High-intensity focused ultrasound (HIFU) may modulate the immunosuppressive tumor microenvironment via immunogenic cell death, yet clinical evidence on HIFU combined with programmed cell dea...

Correlation between high-risk Human Papillomavirus (HPV) viral load and cervical lesions across different subtypes, along with the development of a clinical prediction model

Abstract Objective The study aims to investigate the correlation between the viral loads of HPV16/18 and 16 other high-risk HPV types (designated as non-16/18 group) and the severity of cervical lesions, and to develop a HSIL+ risk prediction model to furnish evidence for pragmat...

Organizing Large GTPase Atlastin‐Mediated Membrane Fusion by Programmable DNA Origami Platforms

ABSTRACT In eukaryotic cells, the endoplasmic reticulum (ER) utilizes membrane fusion to form interconnected networks. GTP hydrolysis‐triggered conformational changes in ER‐anchored atlastins (ATLs) have been shown to be responsible for this process, which is facilitated by the a...

Tibial cortex transverse transport accelerates diabetic wound healing via systemic mobilization of non-classical monocytes

Aims: To clarify the immunomodulatory mechanisms by which tibial cortex transverse transport (TTT) accelerates wound healing in a type 2 diabetic rat model, with particular focus on the dynamics of subsets of monocytes and macrophages. Methods: A total of 186 male Sprague-Dawley...

Adaptive intrathecal nanorobotics in mice and nonhuman primates for navigated CNS therapy

Intrathecal delivery for central nervous system (CNS) therapy lacks spatiotemporal control due to spinal canal anatomical constraints, especially at human scale. We developed an adaptive magnetic nanorobotic platform enabling multimode swarm mobility for in vivo spinal canal navi...

Association between operative duration and prolonged intensive care unit stay for more than 24 h in lung cancer patients following thoracoscopic lobectomy: a retrospective cohort analysis

Lung cancer remains the primary cause of cancer-related mortality worldwide. While prolonged operative duration is increasingly recognised as a modifier of surgical risk, its independent association with prolonged intensive care unit (ICU) stay for more than 24 h following thorac...