Chinese Academy of Sciences

High–spatiotemporal resolution deuterium metabolic imaging enables in vivo phenotyping of intra- and intertumoral heterogeneity

Intra- and intertumoral heterogeneities raise fundamental biological questions and have important implications for accurate cancer diagnosis, prognosis, and treatment. These heterogeneities reflect tumor complexity, including a pronounced diversity in metabolic phenotypes and pro...

Modular Sensory and Morphological Adaptations Underlying Fresh-Fruit Exploitation in Drosophilid Flies

(1) Background: Drosophilid flies oviposit in damaged or fermenting substrates, whereas D. suzukii prefers to lay eggs in ripening fruits. This ecological shift requires females to recognize fruit-stage cues while overcoming the mechanical barrier imposed by fresh-fruit surfaces....

Unveiling the cooling effects of urban green spaces in Eastern China: spatial heterogeneity, diurnal asymmetry, and nonlinear margins of 2D/3D features

Urban green spaces (UGS) play an important role in mitigating urban heat island effects. However, the mechanisms underlying their cooling effects are still not fully understood, particularly regarding the role of three-dimensional vegetation structure and nonlinear threshold resp...

Microstructural evolution of SIMP steel during martensitic transformation

SIMP steel, a reduced activation ferritic/martensitic heat–resistant steel, is a promising candidate for structural applications in future nuclear fusion reactors. Understanding the evolution of microstructure in SIMP steel is of practical importance for improving the structural...

Asymmetric RBBP7 regulates the first cell fate decision of early mammalian embryos

Asymmetric transcription of noncoding RNA LincGET is currently recognized as the earliest event regulating the first cell fate decision in mammalian embryogenesis. However, whether key protein factors modulate this process remains elusive. Here, we identify RBBP7 as the earliest...

Ultra-Short Hollow-Core Anti-Resonant Fiber Polarization Filter Covering C+L Band Based on SPR Effect

This paper proposes an ultra-short hollow-core anti-resonant fiber (HC-ARF) polarization filter covering the C+L communication band based on the surface plasmon resonance (SPR) effect. The structure consists of six composite tubes, each formed by nesting an elliptical cladding tu...

Gate-imprinted memory and light-induced erasure of superconductivity at KTaO3-based interfaces

Realizing non-volatile control of superconductivity is a key step toward integrating memory and quantum functionality in future information technologies. KTaO₃-based heterostructures uniquely host interfacial two-dimensional superconductivity and quantum paraelectric lattice back...

Effects of powder forming method and heat treatment process on microstructure and mechanical properties of ATI 718Plus alloy by laser additive manufacturing

ATI 718Plus alloy powders were prepared by vacuum induction melting gas atomization (VIGA) and plasma rotating electrode preparation (PREP) methods. Effects of direct aging (DA) and homogenization-solution-aging (HSA) heat treatment processes on microstructure and mechanical prop...

Altitude-dependent role of nitric acid in iodic acid-iodous acid nucleation: from marine boundary layer catalyst to upper troposphere core component

Abstract. With global sulfur emissions declining and concurrent marine iodine emissions rising, new particle formation (NPF) driven by iodic acid (HIO3) and iodous acid (HIO2) has become critical to global aerosol and cloud condensation nuclei (CCN) budget. However, the role of u...

Environmental DNA Metabarcoding Reveals the Variations in Fish Diversity Across the Yangtze River Basin and the Effects of the Three Gorges Dam

It is imperative that freshwater fish biodiversity research incorporates diverse components, encompassing taxonomy, phylogeny and function, alongside multifaceted facets, including richness, divergence and regularity. This comprehensive approach is essential to facilitate a more...

Tourism Demand Probabilistic Interval Forecasting Approach With Integrated Deep PatchTST‐GMM Model

ABSTRACT Tourism demand forecasting is an important guide for decision‐making in related industries, especially because interval forecasting can provide managers with more decision‐relevant information than a single point estimate. In order to better forecast tourism demand, this...

Diffusion‐Driven Macromolecular Self‐Organization Enables Conformal Perovskite/Silicon Tandems

ABSTRACT Industrial deployment of perovskite/silicon tandem solar cells is limited by the difficulty of forming thick, defect‐controlled wide‐bandgap (WBG) perovskite layers that conformally coat micron‐textured silicon while retaining interfacial passivation. Here, we introduce...

Performance of a novel double-sided irradiation receiver for next-generation solar power tower systems

In solar power tower systems, conventional cylindrical receivers suffer from severe circumferential temperature non-uniformity and excessive thermal stress due to single-sided irradiation. To address these issues, this study proposes a novel double-sided irradiation receiver conc...

Inferring tumor dependency maps from histopathology through imputed transcriptomics

Gene dependency maps from cancer cell lines define context-specific essential genes, but comparable dependencies in tumors remain largely inaccessible. This gap limits the identification of actionable therapeutic vulnerabilities. Here we present a two-stage deep learning framewor...

Sensitivity Study of the Reactivity-Equivalent Physical Transformation Method for Fluoride Salt Coolant Pebble Bed Reactor Lattice

Conventional dispersed-particle fuel systems, such as TRISO fuel, exhibit typical double heterogeneity. The Reactivity-equivalent Physical Transformation (RPT) method can convert a double-heterogeneity system into a single-heterogeneity system by simplified geometric modelling. I...

Effectiveness of sexual health interventions in reducing risky sexual behaviors among people living with HIV: a network meta-analysis and systematic review

Abstract Objectives To assess and rank the effectiveness of different sexual health interventions designed to address risky sexual behaviors in PLWH. Methods We systematically searched studies published between Jan. 2010 and Dec. 2024. Randomized controlled trails (RCTs) were inc...

Efficient Discovery of Motif Transition Process for Large-Scale Temporal Graphs

Understanding the dynamic transition of motifs in temporal graphs is essential for revealing how graph structures evolve over time, identifying critical patterns, and predicting future behaviors, yet existing methods often focus on predefined motifs, limiting their ability to com...

Soil Hydrothermal Response to Seasonal Freeze–Thaw Processes in Low-Water-Content Sandy Gravel Deposits

Seasonal freeze–thaw processes affect soil hydrothermal conditions in high-altitude valleys, yet evaluations based only on air temperature or maximum freezing depth may overlook the distinction between surface-connected freezing and delayed thawing within the soil profile. Meteor...

Unlocking the Anticancer Potential of Patchouli Leaves: Molecular Mechanisms and Translational Perspectives

Cancer remains one of the leading causes of global mortality, with its incidence continuing to rise due to population growth, aging, lifestyle factors, and environmental exposures. Despite significant advances in early diagnosis and therapeutic strategies, the clinical management...

A Hardware-Error-Aware Time-Domain CIM Accelerator for AdderNet with Significance-Aware Dual-Mode DTC Encoding and Shared-Clock TDC Readout

Adder neural networks remove multiplication from convolution, yet their direct L1-distance datapath still requires subtraction, absolute-value generation, and wide accumulation. We address this cost by mapping the online L1 operation to minimum selection and time-domain accumulat...