Chiba University

Prevalence and predictors of pulmonary hypertension in patients with progressive pulmonary fibrosis: A retrospective study

Background Pulmonary hypertension (PH) complicates interstitial lung disease (ILD) and worsens patient outcomes; however, data beyond idiopathic pulmonary fibrosis (IPF) are limited. This study evaluated PH prevalence in progressive pulmonary fibrosis (PPF) and identified predict...

Shall we score? The SHALL-WE score for optimizing sclerotherapy in superficial lymphatic malformations

No standardized tool guides the decision of when to escalate beyond sclerotherapy in lymphatic malformations (LMs). We developed the SHALL-WE score (Severity, Histology, And Location—Lymphatic malformation: When to Escalate) to define the optimal sclerotherapy threshold in superf...

Spatial Control of Spontaneous Orientation Polarization for Efficient Charge Separation in Organic Photovoltaics

ABSTRACT Spontaneous orientation polarization (SOP) offers a unique approach to generating internal electric fields in organic photovoltaics (OPVs). However, in conventional high‐performance OPVs based on bulk heterojunction architectures, the complex nanoscale morphology makes i...

Altered Cerebral Perfusion and the Emergence of Schneiderian First-Rank Symptoms Following Modified Electroconvulsive Therapy in Late-Life Depression

Electroconvulsive therapy (ECT) is a well-established treatment for severe or treatment-resistant major depressive disorder and schizophrenia, often leading to rapid symptom improvement. However, ECT can rarely cause adverse psychological effects, including new-onset auditory hal...

Zero-field NMR for the Antiferromagnetic Phase of α -Mn at Ambient Pressure

We performed detailed zero-field nuclear magnetic resonance measurements of α-Mn at ambient pressure to clarify its antiferromagnetic phase evolution. The 55 Mn internal magnetic field at site III vanishes continuously as the Néel temperature T N1 = 95 K is approached, which is c...

Age and sex estimation from Japanese femoral computed tomographic images using foundation models

OBJECTIVE: This study evaluated the feasibility and performance of a deep learning-based multitask framework for estimating sex and age using femoral CT images in a Japanese population. MATERIALS AND METHODS: Postmortem CT (PMCT) data from 1,489 Japanese individuals (1,003 males,...

Spatial, Behavioral, and Experiential Associations with Place Attachment Among Engaged Area Users: A Cross-Sectional Study in Shimokitazawa, Tokyo

Place attachment is important in urban planning and environmental psychology, yet the relationships among spatial, behavioral, and experiential factors and place attachment remain insufficiently understood. This cross-sectional study examined these associations among users engage...

In Situ X-ray Scattering for Doxorubicin-Loaded Liposomes to Elucidate the Morphological Change Mechanism Depending on the Cooling Rate and Cholesterol Content

Abstract Doxorubicin (DOX)-loaded liposomes are one of the most established and clinically relevant nanomedicines in a drug delivery system. In this study, we elucidate the mechanistic relationships among cooling rate, lipid composition, and the resulting morphological evolution...

Navigating the sedation challenge in frail older patients undergoing endoscopic retrograde cholangiopancreatography: a narrative review

Abstract The global increase in life expectancy has resulted in a higher volume of endoscopic retrograde cholangiopancreatography (ERCP) procedures among frail older patients. Frailty, a multidimensional syndrome characterized by decreased physiological reserve, presents signific...

Response to “Sample Representativeness and Test–Retest Reliability in the Japanese Everyday Ageism Scale: A Methodological Reconsideration”

The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.

Histological Determinants of Atrial Dysfunction in Patients With Atrial Fibrillation

Background Atrial fibrillation (AF) is associated with diverse histological abnormalities, but their contributions to atrial dysfunction and functional recovery remain unclear. Methods In a discovery cohort of 375 patients with nonvalvular AF undergoing catheter ablation, atrial...

FLRSP: privacy-preserving federated learning using randomly selected model parameters

In this paper, the authors propose a method for privacy-preserving federated learning (FL) that uses randomly selected model parameters to update global models. High-quality deep neural network models require a huge amount of training data in general, but model training raises pr...

P1.118. Delaying the Treatment Schedule in First-Line Chemotherapy Including ICIs for Esophageal Cancer Does Not Affect Survival Outcomes

Abstract Topic Esophageal Cancer: Non-Surgical Treatment of Esophageal Cancer Background Cancer immunotherapy has dramatically changed the management of esophageal cancer. However, the impact of treatment delays on survival outcomes in first-line chemotherapy for esophageal squam...

OA03-RF01.11. Elucidation of the Function of Proline Isomerase Pin1 on Esophageal Squamous Cell Carcinoma

Abstract Topic Esophageal Cancer: Molecular Biology/Pathology Background Esophageal squamous cell carcinoma (ESCC) shows limited response to anti-PD-1 monotherapy, prompting interest in combination treatments. Pin1, highly expressed in ESCC and other cancers, drives malignancy. S...

Geneformer-guided multiomics integration identifies Pbx1 as a network hub of hematopoietic stem cell aging

Hematopoietic stem cells (HSCs) constitute an organized hematopoietic system that undergoes age-related alterations, including increased platelet production and decreased erythropoiesis. The fundamental mechanisms driving these shifts remain incompletely understood. We used singl...

Little Red Dots host Black Hole Stars: A unified family of gas-reddened AGN revealed by JWST/NIRSpec spectroscopy

Abstract We construct and characterise a sample of 146 little red dots (LRDs) across 2.0 < z < 9.3, selecting all sources with v-shaped UV-optical continua from JWST NIRSpec/PRISM spectra and compact morphologies in NIRCam/F444W imaging. We show that LRD continuum spectra are wel...

Preoperative computed tomography measurement for predicting difficulty in hand-sewn ileal pouch-anal anastomosis: a refined single-center cohort study

Restorative proctocolectomy with a hand-sewn ileal pouch-anal anastomosis (IPAA) is a standard treatment for ulcerative colitis and familial adenomatous polyposis. However, achieving sufficient mesenteric length remains a significant challenge. This study aimed to validate the po...

Serum anti-POTEE antibodies as a novel serological biomarker for early detection and prognostic stratification in gastrointestinal cancers

Abstract Background Given the highly aggressive nature of gastrointestinal cancers, the identification of novel biomarkers for diagnosis and prognosis is of considerable clinical importance. Methods Candidate cancer-testis (CT) antigens were first screened using RNA-sequencing da...

Machine-Learning Analysis of the Electronic Structure of Atomically Thin MnTe Films from Scanning Tunneling Spectroscopy

Layered two-dimensional (2D) van der Waals magnetic crystals based on 3d transition metals and chalcogenides are typically synthesized by chemical vapor transport, while establishing epitaxial, layer-by-layer growth under vacuum remains essential for device applications. Here, we...