Chiba University

Fibroblast-like synoviocytes exacerbate autoimmune arthritis upon psychological stress in an IL-6–dependent manner

Psychological stress affects the immune system and exacerbates autoimmune diseases such as rheumatoid arthritis (RA), but the mechanisms underlying tissue inflammation during remission remain unclear. Here, we show that tube restraint stress exacerbates joint inflammation in a mu...

Spectral signatures of zenith sky radiance from surface-based sky radiometers: implications for clear- and cloudy-sky detection

Abstract. Accurate identification of clear- and cloudy-sky conditions is essential for reliable aerosol and cloud retrievals from ground-based remote sensing observations. This study investigates the spectral characteristics of zenith radiances measured by SKYNET sky radiometers...

Personalized haemodynamic modelling for non-invasive quantification of arterial stiffness in the human vasculature

Arterial stiffness is a pivotal predictor of cardiovascular events, yet its in vivo characterization remains elusive because arterial wall mechanics cannot be directly measured. Conventional inverse approaches require high-resolution imaging to resolve wall motion, restricting th...

2026 revised CVIT clinical expert consensus on drug coated balloons for coronary artery disease

Abstract Drug-coated balloons (DCBs) are attracting attention as a therapeutic alternative to drug-eluting stents (DES) in percutaneous coronary interventions. DCB technology allows direct delivery of antiproliferative drugs to the vessel wall without implantation of a permanent...

Patient Posture-Adaptive Non-Contact Respiratory Rate Measurement Inside a Moving Ambulance Using RGB and Thermal Cameras

Background/Objectives: Monitoring and evaluating respiratory rate (RR) plays a critical role during emergency transport. Conventional RR measurement methods have primarily relied on electrocardiogram-based approaches, which are susceptible to large errors caused by patient body m...

RBD-down stabilization of SARS-CoV-2 spike enhances cross-neutralizing antibody responses by redirecting immunodominance toward conserved epitopes

The continuous emergence of SARS-CoV-2 variants has enabled partial escape from neutralizing antibodies, necessitating frequent updates of vaccine antigens. These observations motivate vaccine strategies that can redirect antibody responses toward conserved regions of the spike (...

Screening Tunnel Configurations for Reduced Micro-UAV Hover Performance Using Marker-Based Visual Measurements

Micro-unmanned aerial vehicles (micro-UAVs) used for tunnel inspection must hover near structural boundaries that can affect the combined vehicle–environment response. This paper presents an outcome-based physical method for screening tunnel configurations through marker-linked f...

Targeting the CD4+ effector memory T cells re-expressing CD45RA suppressor galectin-7: a multi-omics-guided therapeutic strategy for idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease with limited therapeutic options. Although single-cell and spatial transcriptomics have revealed cellular heterogeneity within the IPF lung microenvironment, the immune drivers with causal rel...

Cesarean delivery and overweight at 6 years of age: a prospective cohort analysis of the Japan Environment and Children’s Study

Abstract Cesarean delivery (CD) has been suggested as a potential risk factor for childhood overweight and obesity; however, evidence beyond early childhood remains inconsistent. We examined the association between CD and childhood overweight at age 6 years and explored early lif...

Long-term results of stereotactic body radiotherapy boost in patients with cervical cancer considered unsuitable for intracavitary brachytherapy

Abstract Purpose Although stereotactic body radiotherapy (SBRT) boost represents a promising treatment option for patients with locally advanced cervical cancer who were considered unsuitable for brachytherapy, its long-term efficacy and safety remain unclear. This study assessed...

Hour-scale response of low-Earth-orbit satellite altitude to extreme geomagnetic storms revealed by the NinjaSat CubeSat during the 2024 solar maximum

Abstract Extreme geomagnetic storms accelerate low-Earth-orbit satellite decay by inflating the thermosphere, yet the hour-scale pathway from solar-wind energy to atmospheric heating is poorly understood. Using the GNSS receiver of the NinjaSat CubeSat ( $$\sim 500$$ km, $$97^\ci...

Impact of third-party accreditation and general medicine in-training examination participation on residency program popularity: a nationwide matching data analysis in Japan

Abstract Background Third-party accreditation and the visibility of educational outcomes may influence medical students’ choice of training sites; however, national evidence of their effect in Japan is limited. This study examined whether hospital characteristics—especially Japan...

Neural Correlates of Apathy in Multiple System Atrophy: A Clinical and Perfusion Imaging Study

BACKGROUND: Apathy is a frequent nonmotor symptom of multiple system atrophy (MSA) that worsens quality of life. Although frontostriatal dysfunction has been implicated in apathy, its neural basis in MSA remains insufficiently characterized. OBJECTIVES: To identify the neural sub...

Perioperative determinants of post-induction blood pressure and prophylactic norepinephrine dose estimation in noncardiac surgery: a post hoc analysis of a prospective observational study

Post-induction hypotension is a common complication of general anesthesia and has been associated with adverse postoperative outcomes. We examined factors associated with post-induction minimum mean arterial pressure (MAP) and explored risk-profile–based model-derived norepinephr...

Intravascular imaging in myocardial infarction and ischemia with nonobstructive coronary arteries

Abstract Myocardial infarction with nonobstructive coronary arteries (MINOCA) and angina or ischemia with nonobstructive coronary arteries (ANOCA/INOCA) are heterogeneous syndromes that cannot be adequately characterized by coronary angiography alone. Optical coherence tomography...

Mixed motives and linear forms in the Catalan constant

Abstract We first give a geometric construction of a two‐dimensional mixed motive over with the Catalan constant as a period. We then use this motive to obtain a supply of linear forms in 1 and . We also explicitly compute the coefficients of 1 and in these linear forms.

Time-Course Evaluation of Water and Fertilizer Use Efficiencies and Growth Characteristics of Lettuce Cultivated Under Artificial Light Using a One-Way, Reduced-Discharge Hydroponic Cultivation Unit

The recirculating flow hydroponic cultivation unit (RFC) used in plant factories with artificial lighting requires nutrient solution replacement to prevent growth inhibition caused by nutrient imbalances and allelochemical accumulation. Although sustainable systems are needed to...

Rice Cropping Pattern Mapping Using GEE-Based Sentinel-1/2 Time-Series Imagery and Machine Learning

Accurate mapping of rice cropping patterns is fundamental to sustainable agricultural management and regional food security assessment. In this study, we developed a high-precision mapping framework for major rice cropping patterns in the Yangtze River Delta region, China, using...

Motor cortical excitability in dominant and non-dominant limbs: a transcranial magnetic stimulation study

Abstract Background Threshold tracking transcranial magnetic stimulation (TT-TMS) is increasingly recognized as a promising diagnostic tool for estimating motor cortical excitability, and previous studies have shown hyperexcitability in patients with amyotrophic lateral sclerosis...

Impact of Intercalators on the Properties of DNA Analyzed by Molecular Dynamics Simulations

Abstract Intercalation of small molecules between DNA base pairs affects DNA conformation, disrupting essential cellular processes, including replication, transcription, and repair. We investigated conformational changes in 18-mer DNA upon intercalation of doxorubicin, SYBR Gold,...