Chengdu University of Traditional Chinese Medicine

Natural pollen-derived microcapsules as high-performance auxiliary cleaning particles for personal care

Effective removal of sebum, cosmetic residues, and environmental impurities is essential for high-performance personal cleansers. Nevertheless, developing functional auxiliary cleaning particles with both environmental friendliness and high cleansing performance remains a major c...

ZMIZ1 promotes aerobic glycolysis and development of hepatocellular carcinoma through inducing NOTCH1-mediated transcription of PYCR1

Hepatocellular carcinoma (HCC) is characterized by profound metabolic reprogramming that promotes tumor progression. Although zinc finger MIZ-type containing 1 (ZMIZ1) has been implicated in several malignancies, its biological function and underlying mechanism in HCC remain uncl...

Yiqi Huoxue Compound promotes neuroprotection against ischemic stroke by inhibiting apoptosis through the activation of PI3K/AKT pathway

Yiqi Huoxue Compound (YQHX), a traditional Chinese medicine formulation, has demonstrated therapeutic potential for ischemic stroke (IS). However, its underlying mechanisms are not fully understood. This study aimed to elucidate the neuroprotective effects and mechanisms of YQHX...

Complete biosynthesis of the clinical agent escin Ia

Abstract Escin Ia is a barrigenol-type triterpenoid specific to Aesculus seeds and is widely utilized in clinical practice for the treatment of cerebral edema, swelling, and venous insufficiency. Here, we fully elucidated its biosynthetic pathway by identifying ten previously unc...

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

ABSTRACT The sterility and controllable biological functionalities of implantable medical devices determine their lifespan, safety, and therapeutic efficacy. Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, we have developed a...

Systematic Screening of Depression-Related Neurotoxicity Across 26 Bisphenols Reveals an ESR1–CREB1–GRIN2B-Associated Mechanism

Bisphenols (BPs) are widespread environmental endocrine disruptors, but their potential depression-related neurotoxicity has not been systematically assessed. Here, we combined machine learning (ML), network toxicology, molecular docking, and in vivo experiments to screen 26 bisp...

Diagnostic value of anti-carbamylated protein combined with Anti-RA33 antibodies in seronegative rheumatoid arthritis: a retrospective cohort study

Seronegative rheumatoid arthritis (SNRA), defined by the absence of rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA), poses a persistent diagnostic challenge. Anti-carbamylated protein antibodies (Anti-CarP-IgG) and anti-RA33 antibodies targeting heterogene...

Efficacy and safety of repeated low-level red light therapy in myopia control: an updated and comprehensive systematic review and meta-analysis

This study aims to assess the therapeutic effectiveness and safety of repeated low-level red light for myopia management in children and adolescents. Multiple databases were systematically searched for studies evaluating the efficacy of RLRL in myopia control among children and a...

Recent Advances in Comprehending Endothelial Dysfunction and Diabetic Cardiomyopathy: From Molecular Mechanisms to Clinical Applications

Diabetic cardiomyopathy (DCM) is a cardiac condition characterized by various structural and functional abnormalities that are associated with diabetes mellitus. Its development involves multiple factors, among which endothelial dysfunction plays a significant role. To fully desc...

Oral Edible Zein/CitricAcid Nanocomposite EnablesIntestinal Delivery of Resveratrol for Effective Ulcerative ColitisTherapy

Abstract Resveratrol (Res) is a plant polyphenol with diverse bioactivities, yet its application is limited by poor water solubility and low bioavailability. Therefore, an edible nanodelivery system composed of a zein/citric acid complex was developed to encapsulate Res@ZC-NPs sh...

Determining the minimal clinically important difference for EQ-5D-5L scores in patients undergoing primary total knee arthroplasty

Total Knee Arthroplasty (TKA) is a common procedure for knee osteoarthritis, but the Minimal Clinically Important Difference (MCID) for the EQ-5D-5L scale in TKA patients is not established. This study aims to determine the MCID for EQ-5D-5L in TKA patients. A prospective study w...

taVNS for uterine contraction pain and early recovery after spontaneous vaginal birth: a three-arm randomized controlled trial protocol

Uterine contraction pain after spontaneous vaginal birth (SVB) hinders early maternal recovery. Transcutaneous auricular vagus nerve stimulation (taVNS), as a safe, and non-invasive alternative therapy, can alleviate pain and improve sleep and emotion. Although a recent trial has...

Impact of IL-6 receptor inhibitors on cerebrospinal fluid metabolites in type 2 diabetes patients

This study aimed to investigate whether interleukin-6 (IL-6) receptor inhibitors affect cerebrospinal fluid (CSF) metabolites in type 2 diabetes (T2D) patients. The initial phase employed drug-targeted Mendelian randomization to investigate the association between IL-6 receptor i...

Engineered desialylated platelet membrane camouflaged liposomes for the regulation of kupffer cells and hepatic stellate cells in treatment of liver fibrosis

The intercellular crosstalk and reciprocal activation between Kupffer cells (KCs) and hepatic stellate cells (HSCs) are critical drivers of liver fibrosis progression. Nonetheless, the co-regulation of KCs and HSCs is hindered by their distinct anatomical locations and the pathol...

Rising burden and deepening inequalities: a national study of high BMI-related uterine cancer in the United States using GBD and NHANES data

OBJECTIVE: Uterine cancer mortality is rising in the U.S. while other cancer deaths decline, posing a major public health challenge. High BMI is the strongest modifiable risk factor, but its full burden and associated inequalities remain poorly characterized. METHODS: Using data...

Discovery, Synthesis,and Biological Evaluation of1,3,4,5-Tetrahydro-6 H -pyrano[4,3- c ]isoquinolin-6-one Derivatives as Novel and Highly SelectivePARP1 Inhibitors

Abstract Developing highly selective PARP1 inhibitors is a promising strategy to improve the therapeutic window compared with dual PARP1/2 inhibitors. Through structure-guided design and optimization, we developed (R)-A17, a novel, highly selective PARP1 inhibitor featuring a uni...

Assessing the interactive effects of land use and climate change on species assemblages of giant panda and its sympatric large- and medium-sized terrestrial mammals

Land use and climate change are currently two most important drivers of biodiversity loss worldwide. Although the effect of these two drivers on species assemblages has been widely assessed both in isolation and in combination, their interactive effects (i.e., additive, synergist...

Toxic effects of streptozotocin (STZ)-induced zebrafish and the response mechanism of liver transcriptome

Streptozotocin (STZ) is commonly used to induce diabetes, but its efficacy and systemic toxicity in zebrafish remain controversial. This study evaluated the dose-dependent effects of STZ in adult zebrafish and explored the molecular mechanisms underlying hepatotoxicity using tran...

Comparative therapeutic effects of the proximal femoral bionic nail (PFBN), PFNA, and InterTan for intertrochanteric fractures: a systematic review and network meta-analysis

This study aimed to compare the efficacy of the proximal femoral bionic nail (PFBN), proximal femoral nail antirotation (PFNA), and InterTan in the treatment of intertrochanteric fractures. This network meta-analysis was conducted in accordance with the PRISMA 2020 statement and...

Exposure-informed lung transcriptomic analysis links predicted NNK targets to cell type-specific remodeling programs in idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is associated with cigarette smoking, yet the relationship between the tobacco-specific nitrosamine nicotine-derived nitrosamine ketone (NNK) and IPF-associated lung transcriptional remodeling remains incompletely understood. Here, we developed...