Chengdu University of Traditional Chinese Medicine

Integrative transcriptomic analysis reveals tumor-adjacent mucosal remodeling in colorectal cancer

Tumor-adjacent mucosa is commonly used as a normal reference in colorectal cancer (CRC) transcriptomic studies, but its relationship with distant normal mucosa and tumor tissue remains unclear. Here, we performed bulk RNA sequencing of paired distant normal, adjacent, and tumor t...

Similar degenerative patterns of olfactory receptor genes in the giant panda and marine carnivores

Olfactory receptor (OR) genes constitute the largest mammalian gene family and are critical for olfactory perception and ecological adaptation. OR gene variation is associated with interspecific differences in habitat, diet, and sensory reliance, yet the relative contributions of...

Simulation of behavior of combustion reaction in non-uniform size particle HMX explosives under drop hammer impact based on 3D-DEM

In practice, macroscopic explosives consist of explosive particles of varying sizes, which are referred to as non-uniform size particle explosives in this paper. It is meaningful to study the ignition and combustion of non-uniform size particle explosives for their safety predict...

The Application Potential and Future Challenges of Plant-Derived Exosome-like Nanoparticles in the Treatment of Liver Diseases

Liver disease is a serious global health challenge, with high morbidity and mortality that put significant socioeconomic stress on society. Despite therapeutic advances, current regimens have been limited by rapid drug resistance and insufficient targeting accuracy, and there is...

Research and Application of Tongue Image Segmentation Method Based on Lightweight Deep Learning

Intelligent tongue diagnosis demands high-precision segmentation on resource-constrained mobile devices. All deep learning models outperform conventional approaches, improving mean intersection over union (mIoU) by approximately 9% and accelerating inference by more than two orde...

FAK Mediated Coordination of Extracellular Matrix Remodeling and Cellular Mechanics Impairs Nanomedicine Delivery in Solid Tumors

ABSTRACT Tumor extracellular matrix (ECM) remodeling and cell‐intrinsic mechanical properties critically limit nanoparticle (NP) delivery, yet how these multiscale biophysical cues are coordinately regulated remains unclear. Here, we identify focal adhesion kinase (FAK/ PTK2 ) as...

Integrated LC–MS/MS Metabolomics and 16S rRNA Gene Sequencing to Identify Associated Molecular Signatures of Physalis Calyx seu Fructus Against Acute Pharyngitis

ABSTRACT This study aimed to characterize the metabolic and microbial alterations associated with Physalis Calyx seu Fructus (PCF) treatment in a rat model of acute pharyngitis (AP). The therapeutic effects of PCF on AP were evaluated by assessing physiological characteristics, a...

Distinct profiles of psychological resilience and associated factors among clinical nurses: a latent profile analysis

Abstract Background Clinical nurses work in high-stress environments over extended periods and are prone to occupational burnout. Identifying psychological resources that can effectively help nurses cope with stress and maintain occupational well-being is crucial for nursing mana...

Association between body mass index and sarcopenia in older adults: a systematic review and dose-response meta-analysis

Sarcopenia is a common geriatric syndrome associated with adverse health outcomes in older adults. Body mass index (BMI), a simple anthropometric measure, has been associated with sarcopenia; however, the dose–response relationship between BMI and sarcopenia remains incompletely...

Acupuncture and Moxibustion for Neck Pain: A Clinical Practice Guideline

ABSTRACT Background Neck pain (NP) is a leading cause of disability worldwide. Pharmacological treatments often provide limited benefits and may be associated with adverse effects, highlighting the need for effective non‐pharmacological options. Aim To develop evidence‐based reco...

A Radical Addition–Diradical Coupling Switch Unifies Cytochrome P450-Catalyzed Diketopiperazine Dimerization

Abstract Cytochrome P450 dimerases generate the remarkable structural diversity of dimeric diketopiperazine (DKP) natural products through highly selective intermolecular radical-mediated reactions. Although radical addition mechanisms have been established for most bacterial DKP...

Research Progress on Intraocular Pressure-lowering Drugs, Commonly Used Clinical Adjuvants, and Emerging Neuroprotective Agents for Glaucomatous Optic Neuropathy

Abstract Glaucomatous optic neuropathy (GON) is the leading cause of irreversible blindness worldwide, characterized by progressive retinal ganglion cell (RGC) loss. Current clinical treatment relies primarily on IOP-lowering drugs, but a subset of patients continues to experienc...

Association between living arrangements and long-term health outcomes among older adults with mild cognitive impairment: a longitudinal cohort study using data from a nationally representative survey in China

Living arrangements may reflect both social support and care needs in later life, but longitudinal evidence among older adults with mild cognitive impairment (MCI) remains limited. This study examined the longitudinal associations of time-varying living arrangements with all-caus...

An integrated computational and in vitro framework identifies CTSB and MMP7 as DEHP-responsive candidates in gastric adenocarcinoma

Di(2-ethylhexyl) phthalate (DEHP) is a widespread endocrine-disrupting chemical, but its molecular effects in gastric adenocarcinoma remain incompletely understood. This study integrated network toxicology, multi-cohort transcriptomics, weighted gene co-expression network analysi...

Curcumin Delivery Systems for Inflammatory Skin Application: A Review

Curcumin (CUR) is a low-molecular-weight polyphenolic compound extracted from the rhizomes of the herb Curcuma longa. It exhibits a wide range of pharmacological activities, including anti-inflammatory, antioxidant, hypoglycemic, and antiviral effects. However, its poor solubilit...

Dynamic reconfiguration of directed effective connectivity between attention networks and the default mode network in knee osteoarthritis: a combined resting-state and non-noxious thermal stimulation functional magnetic resonance imaging study

Background: Chronic pain is understood as a disturbance of large-scale brain-network organization involving systems that coordinate internally and externally oriented processing. In knee osteoarthritis (KOA), altered connectivity involving attention networks and the default mode...

Stem cell senescence as a regenerative bottleneck in age-related skeletal degeneration: Mechanistic crosstalk and translational strategies

Skeletal degeneration is a major cause of pain, disability, fragility fracture, and loss of independence in aging populations. Although osteoporosis, osteoarthritis, and intervertebral disc degeneration are usually managed as anatomically separate disorders, they share a common r...

Machine learning combined with multidimensional validation identifies SNCA and NR2F2 as key hubs implicated in paraquat and rotenone co-exposure-induced Parkinson’s disease

Combined exposure to pesticides, such as paraquat (PQ) and rotenone (Rot), is a significant risk factor for Parkinson’s disease (PD). However, the synergistic pathogenic mechanisms underlying their co-exposure remain largely elusive. This study aimed to elucidate the key molecula...

The promising potential of small extracellular vesicles in the field of intervertebral disc repair - a comprehensive meta-analysis

Intervertebral disc degeneration (IDD) is one of the main factors causing chronic low back pain (LBP) and disability, which seriously affects the quality of life of patients and brings heavy social and economic burden. At present, conservative treatment and surgical methods have...

Virtual reality-based therapy for substance use disorder: a systematic review and Bayesian meta-analysis

This Bayesian meta-analysis evaluated virtual reality (VR) therapy for substance use disorder (SUD). A total of 22 studies involving 2648 participants were included. VR-based therapy reduced substance craving compared to controls (standardized mean difference (SMD) = − 0.75, 95%...