Central South University

Fostering Urban Sustainability: A Spatio-Temporal and TextCNN-DID Evaluation of China’s Green Finance Pilots

This paper explores how green finance policies influence the sustainability and resilience of urban areas, particularly those operating under tight fiscal budgets. By treating China’s Green Finance Reform and Innovation Pilot Zone as a quasi-natural experiment, we examine a compr...

Establishing the role of ZBTB20 mutations in GnRH deficiency and impaired neurogenesis in the subventricular zone: a human cohort and animal model study

Background Congenital hypogonadotropic hypogonadism (CHH) arises from defective development or dysfunction of GnRH neurons. Olfactory bulb (OB) malformations frequently accompany CHH, a condition termed Kallmann syndrome (KS). Nevertheless, approximately 50% of CHH cases remain g...

Combined administration of fructooligosaccharides and Clostridium butyricum attenuates bowel cleansing-induced dysbiosis and safeguards mucosal defense in a murine model

Bowel preparation with polyethylene glycol electrolyte solution (PEG-ELS) is indispensable for gastrointestinal endoscopy and related procedures. However, it disrupts gut microbial homeostasis and increases host vulnerability to ensuing infection. In a murine model, we optimized...

KG-MS-ResNet: A Knowledge-Guided Multi-Scale Attention Residual Network for Cultivated Land Change Monitoring

Abstract. Cultivated land conversion to built-up area is the core form of farmland non-agriculturalization and the main threat to farmland protection. China has strict requirements for safeguarding farmland security and holding the 1.8-billion-mu farmland red line. However, curre...

Surgical hip dislocation for the phosphaturic mesenchymal tumor of the femoral head and neck: a clinical outcome analysis

This retrospective study aimed to characterize the clinical, radiographic, and biochemical outcomes of surgical hip dislocation (SHD) combined with intralesional curettage and bone grafting for the treatment of phosphaturic mesenchymal tumors (PMT) of the femoral head and neck. A...

ModernizingTraditional Mineral Medicine: Pyrolusite-DerivedMnO2 Nanoplatform for Osteo-Angio-Immunomodulatory BoneRepair

Abstract Pyrolusite, a traditional mineral medicine rich in manganese, has long been used to promote fracture healing; however, its complex composition, limited bioavailability, and poorly defined mechanisms have hindered its modernization and clinical translation. Here, we prese...

Smart nanoparticle-assisted nucleic acid delivery for targeted therapy and tissue repair

Tissue repair necessitates precise temporal regulation of cell proliferation, differentiation, and angiogenesis. Nucleic acid drugs exhibit significant therapeutic potential, but they encounter challenges such as low delivery efficiency, nuclease degradation, poor membrane penetr...

Hydrophobic Eutectogels Reinforced by Zn2+-Coordinated Lignin Nanoparticles for Underwater Wearable Electronics

Abstract Wearable flexible sensors for underwater communication and biomotion monitoring are gaining attention. However, developing gel-based strain sensors with high toughness, anti-swelling performance, robust underwater adhesion, and long-term stability remains challenging. He...

Thyroid function and hypertensive disorders of pregnancy: Insights from a sex‐specific cohort study, Mendelian randomization, and experimental validation

OBJECTIVE: To investigate the association of a history of hypertensive disorders of pregnancy (HDP) and a higher risk of cardiovascular disease using a sex-specific cohort study, bidirectional two-sample Mendelian randomization (MR), and in vitro experiments. METHODS: Multivariab...

Hepatic GPR110 plays a complex and context-dependent role in metabolic dysfunction-associated steatotic liver disease

Metabolically-dysfunction-associated steatotic liver disease (MASLD)—formerly known as nonalcoholic fatty liver disease (NAFLD) —is now the most common chronic liver disease worldwide, affecting more than 30% of the global population. Recent studies have documented seemingly cont...

Microglia replacement therapy for neurological diseases: a mechanistic perspective focused on the Golgi apparatus

Microglia-mediated neuroinflammation is a pathological hallmark of various neurological diseases. Altered microglial states promote disease progression and induce an inflammatory microenvironment. Therapies aimed at modulating microglial signaling demonstrate certain therapeutic...

Ferroptosis as a central mechanism in inhaled tris(1-chloro-iso-propyl) phosphate (TCIPP)-induced lung injury: Associations with pyroptosis and mitochondrial dynamic imbalance

), along with elevated ferroptosis markers (p53, Transferrin Receptor 1 (TFR1)) and reduced FTH1 levels following TCIPP inhalation. These effects were counteracted by the ferroptosis inhibitor Fer‑1 (0.8 mg/kg), which also attenuated pathological damage, ROS accumulation, and NLR...

The influence of MoS 2 lubricity on the secondary cutting performance of PCD micro-groove textured tools

Micro-textured cutting tools possess unique advantages in reducing cutting forces, lowering chip temperatures, minimizing tool wear, and improving machined surface quality. Nevertheless, the secondary cutting effect induced by micro-textures impairs texture integrity and aggravat...

Phenotypic divergence in rotator cuff tear and volumetric muscle loss mouse models following fibroadipogenic progenitor depletion

Aims: Fibroadipogenic progenitors (FAPs) are a group of resident muscle stem cells capable of differentiating into fibroblasts and adipocytes, contributing to intramuscular fibrotic and fatty degeneration after injury. However, FAPs are also thought to play a crucial role in musc...

Recent Advances in Interfacial Chemistry for Solid‐State Lithium–Sulfur Batteries

ABSTRACT All‐solid‐state Lithium–sulfur batteries (ASSLSBs) have emerged as a highly promising candidate for next‐generation energy storage systems, featuring a unique combination of earth‐abundant sulfur cathodes, high‐capacity lithium metal anodes, and nonflammable solid‐state...

Alternative polyadenylation in cancer: mechanisms, functions, and therapeutic potential

Alternative polyadenylation (APA) is a pervasive post-transcriptional regulatory mechanism that generates transcript isoforms with distinct 3′ untranslated regions, terminal exons, or coding potential, thereby influencing mRNA stability, translation, localization, and protein out...

Analytical Method for Surrounding ROCK Pressure of Shallow-Buried Double-Arch Tunnels Under Variable-Slope Ground Surfaces

Based on limit-equilibrium theory, a calculation method for the surrounding rock pressure of shallow-buried variable-slope arch tunnels is proposed. A calculation model for surrounding rock pressure of variable-slope surfaces is established according to the structure and stress c...

Developing purposeful observation during early clinical exposure in anesthesiology: a cluster-randomized study

Early clinical exposure allows undergraduate medical students to encounter authentic clinical practice, but novice learners may not know what to observe or how to interpret complex clinical events. This challenge is particularly relevant in anesthesiology, where many professional...