Central South University

Agentic echocardiography report structuring for cardiovascular prediction and disease association discovery

Noisy echocardiography reports limit data-driven cardiovascular research because measurements that matter for downstream modelling remain in scanned images, multilingual narratives or semi-structured tables. This study presents an end-to-end agentic pipeline that takes such repor...

Reconstructing Solvation Structure via Strongly Nucleophilic Anions for High‐Rate and Low‐Temperature Graphite||LFP Pouch Cells in PC‐Based Electrolyte

ABSTRACT Regulating Li + solvation structure in Propylene carbonate (PC)‐based electrolytes modulates solid‐electrolyte interphase (SEI) formation and desolvation, enabling compatibility with graphite anodes. However, existing high‐ and localized high‐concentration strategies rem...

Dual-organelle–coordinated sonodynamic nanoplatform amplifies immunogenic cell death to drive robust antitumor immunity in cold tumors

Immune-excluded “cold” tumors are characterized by dense stromal barriers, limited cytotoxic T-cell infiltration, and insufficient immunogenic cell death (ICD), which collectively restrict the efficacy of immunotherapy. Pancreatic ductal adenocarcinoma (PDAC) and triple-negative...

Enzymatic Ligation-Enhanced Catalytic Hairpin Assemblyfor Accelerated Kinetics with Restricted Leakage

Abstract Enthalpy-driven catalytic hairpin assembly (CHA) suffers from an inherent trade-off, wherein enhanced reaction kinetics is inevitably accompanied by elevated nonspecific background. Catalytic hairpin assembly-and-cyclization (CHAC) integrates CHA with enzymatic ligation,...

Species discordance in diatom testing for drowning diagnosis: a biological passive sampling hypothesis with forensic implications

Diatom testing is a key technique for forensic drowning diagnosis, yet species discordance between diatom taxa in victim tissues and water samples from the recovery site remains a major medico-legal challenge, often misattributed to technical errors or post-mortem contamination....

Hierarchical ROS-scavenging hydrogel system for coordinating the modulation of RGC necroptosis and oxidative stress in an acute glaucoma model

Glaucoma, a leading cause of irreversible blindness, is characterized by the progressive loss of retinal ganglion cells (RGCs). Beyond intraocular pressure (IOP)-dependent injury, IOP-independent pathways, specifically the self-amplifying axis between oxidative stress and the nec...

Optimal FBG Sensor Layout Assessment for Accurate Structural Feature Recognition of Composite Plates

Carbon fiber-reinforced polymer (CFRP) composites are increasingly used in aerospace, rail transportation, and energy engineering owing to their high specific strength and corrosion resistance. However, their complex and interacting damage mechanisms, including delamination and m...

The World Psychiatric Association (WPA) Guideline on Schizophrenia Spectrum Disorders Management for Low- and Middle-Income Countries

There is a pressing need to address the unique challenges of managing Schizophrenia Spectrum Disorders (SSD) in Low- and Middle-Income Countries (LMICs), where mental health resources are scarce and unevenly distributed. To develop this evidence-based guideline, we conducted a sy...

Real-world evidence of immunotherapy in older adults with advanced non-small cell lung cancer: a retrospective cohort study

Older patients are underrepresented in clinical trials of immunotherapy for driver gene-negative advanced non-small cell lung cancer (NSCLC). This study aimed to investigate real-world efficacy and safety of immunotherapy in this population. Clinical data from 649 patients aged ≥...

Development and validation of a two-gene urine DNA methylation assay for noninvasive prostate cancer detection: a prospective multicenter study

Prostate-specific antigen (PSA) screening lacks specificity, particularly within the 4-10 ng/mL diagnostic gray zone, leading to unnecessary prostate biopsies and overtreatment. Here, we developed and validated a streamlined urine DNA methylation assay for non-invasive prostate c...

Self‐Assembly of Organic–Inorganic Copolymers Toward Bio‐Inspired Cementitious Composites

ABSTRACT Refined by millions of years of rigorous evolution, highly mineralized biological materials have perfected organic–inorganic self‐assembly to break the traditional trade‐off between strength and damage tolerance. Their rigid‐flexible precursor architectures motivate an o...

Redox‐Pathway Reconstruction in Carbonate Electrolyte to Achieve Durable Na─S Battery

ABSTRACT The practical performance of room‐temperature sodium–sulfur (RT Na─S) batteries in low‐solubility carbonate electrolytes is fundamentally constrained by slow “solid‐solid” sulfur conversion, causing incomplete redox reactions and rapid capacity fading. Herein, we propose...

Stress Hyperglycemia Drives CD4 + T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

ABSTRACT Perioperative stress hyperglycemia is a transient but frequent metabolic disturbance strongly linked to postoperative organ injury and mortality; however, the immunometabolic mechanisms driving this association remain largely undefined. In a two‐center cohort of patients...

Synergistic Constructionof Composite Conductive Networksand Particle Size Gradation toward High-Volumetric-Energy-DensityLiMn x Fe1– x PO4 Cathodes

Abstract The commercial deployment of LiMnxFe1–xPO4(LMFP) cathodes is hindered by the Mn3+ Jahn–Teller effect, low electronic conductivity, and low compacted density resulting from intensive gas evolution during conventional pyrolysis. Herein, a comprehensive modification strateg...

Targeted Restoration of Mitophagy Reinvigorates Aged Hematopoietic Stem Cells

Aims: Aging-related functional decline in hematopoietic stem cells (HSCs) is closely associated with mitochondrial dysfunction and impaired mitophagy. This study aimed to investigate whether targeted restoration of mitophagy via the myeloid cell leukemia 1 (MCL-1)/light chain 3A...

Baseline Response Characterization and Relative Vertical Displacement Reconstruction of Multi-Layer Asphalt Pavements Based on Quasi-Distributed FBG Monitoring Information

Internal responses of multilayer pavement structures are difficult to characterize using surface-based inspection alone. This study investigates a scaled multilayer pavement model instrumented with embedded quasi-distributed fiber Bragg grating (FBG) sensing lines to obtain basel...

Redox‐Pathway Reconstruction in Carbonate Electrolyte to Achieve Durable Na─S Battery

ABSTRACT The practical performance of room‐temperature sodium–sulfur (RT Na─S) batteries in low‐solubility carbonate electrolytes is fundamentally constrained by slow “solid‐solid” sulfur conversion, causing incomplete redox reactions and rapid capacity fading. Herein, we propose...

The Carbon Trap: Fragmentation, Accounting Hegemony, and Justice in Global Carbon Governance

ABSTRACT Carbon accounting is increasingly treated as the technical foundation of global climate action, yet the rules through which emissions are measured, converted, attributed, and disclosed remain fragmented across national inventories, corporate reporting standards, supply‐c...

Transverse V-Y Mucosal Advancement Flap for Reconstruction of Labial Mucosal Defects: A Clinical Application

OBJECTIVE: To evaluate the clinical efficacy of the transverse V-Y advancement mucosal flap for reconstruction of small- to medium-sized lip mucosal defects. METHODS: Clinical data from 17 patients who underwent reconstruction of lip mucosal defects following resection of benign...

Towards Sustainable Ecotourism in a Proposed Karst National Park, Southwest China: A Social-Ecological Adaptability Assessment and Zoned Management Strategy

This exploratory case study assesses ecotourism adaptability across three zones within the proposed Southwest Karst National Park (Guangxi), where UNESCO-recognised geological heritage intertwines with diverse ethnic cultures. To fill the gap in zone-specific integrated assessmen...