Brown University

Platelet-Rich Plasma Facet Joint Injections for Post-Traumatic Lumbar Facet-Mediated Pain: A Two-Patient Case Report

Background Lumbar facet-mediated pain is a common contributor to axial low back pain and may occur after traumatic or mechanical injury, even when advanced imaging demonstrates only mild degenerative or nonspecific findings. Standard interventional treatment pathways often includ...

Protocol of a randomized controlled trial evaluating telehealth delivery of the Brief Alcohol Screening and Intervention for College Students (BASICS) program

This study is a randomized controlled trial evaluating a telehealth version of the Brief Alcohol Screening and Intervention for College Students (BASICS) program as an equally efficacious alternative to the traditional in-person implementation. The study will recruit 600 college...

The Role of Assignment in Defining and Identifying Causal Effects in Randomized Trials

In randomized trials, the per-protocol effect is defined as the effect of being assigned a treatment strategy and receiving treatment according to the assigned strategy; therefore, it encompasses the effect of the treatment strategy and any effect of assignment that does not oper...

Understanding the Impact of Living Situation and Social Satisfaction on Depression and Substance Use in Autistic Young Adults Without Intellectual Disability

Background: Autistic young adults face elevated risks for depression, and emerging evidence indicates that some engage in substance use. Residential status and social satisfaction may be related to these outcomes, yet little research has examined their interplay in autistic popul...

Management of Infantile Epileptic Spasms Syndrome: A survey of US pediatric hospitals

Abstract Objective To evaluate the management practices of Infantile Epileptic Spasms Syndrome (IESS) across tertiary pediatric hospitals in the United States using a survey‐based approach. Methods A 21‐question survey focused on management setting, work‐up, follow‐up and treatme...

Endovascular Thrombectomy for Cerebral Venous Thrombosis: Current Status and Future Directions

Abstract Cerebral venous thrombosis (CVT) represents a relatively rare cause of stroke, yet it carries an overall rate of death or dependency of up to 15%. The mainstay of its management is therapeutic anticoagulation, either subcutaneously or intravenously in the acute phase, fo...

Four decades of tinnitus pathology research: a bibliometric analysis of scientific trends, collaborations, and research hotspots

Abstract Introduction Tinnitus is a debilitating auditory disorder affecting approximately 14% of adults worldwide, often co-occurring with hearing loss, sleep disturbance, anxiety and depression. Despite its high global prevalence and substantial socioeconomic burden, tinnitus r...

A foundation model for sleep-based risk stratification and clinical outcomes

Abstract Clinical sleep studies capture multiple physiologic signals, yet interpretation is often reduced to single summary measures of limited prognostic value, such as the apnea–hypopnea index. We present a foundation model that learns rich representations of sleep physiology f...

A Decade of Pathways to Medicine: Program Evaluation and Lessons Learned in Implementing a Local Health-Professions Outreach Program.

Pathway programs provide structured opportunities for students to explore healthcare careers and develop familiarity with educational pathways into the health professions. Ongoing evaluation of such programs is essential to gauge their success and inform iterative improvement. In...

Characteristics and Management of Xylazine-Associated Wounds: A Systematic Review of Published Cases.

BACKGROUND: The rise in xylazine-adulterated fentanyl and heroin has been designated as an emerging public health threat due to a devasting pattern of xylazine- associated wounds associated with its injection. This study was undertaken to systematically characterize patient and w...

Outcomes of a Novel Full-Service, Free Ophthalmology Clinic-Within-A-Clinic: A Four-Year Longitudinal Study.

PURPOSE: We evaluate the Clínica Esperanza Ophthalmology Service, a free service for uninsured patients in southern New England. METHODS: The service operates monthly under a novel clinic-within-a-clinic model, existing as a subsidiary of a local free clinic. A mixed-methods prog...

Changes in Diet Among Adult Prevalent Kidney Stone Formers in the United States: The National Health and Nutrition Examination Survey, 1988-2018.

BACKGROUND/PURPOSE: Dietary factors greatly influence kidney stone disease (KSD). We aimed to examine the dietary pattern changes of adult stone formers (SF) in the United States from 1988 to 2018. METHODS: We used weighted, multiple linear regression analyses to examine dietary...

Evaluation of Emergency Department Visits by Refugee Children in Rhode Island.

Children constitute 40% of the world's refugees and often have complex medical needs. This retrospective chart review examined Emergency Department (ED) utilization by pediatric refugees (aged 0-18) within a state-level healthcare system to understand the healthcare needs of this...

Early life sugar rationing and ageing related diseases, biological ageing and mortality

Early-life nutrition may influence lifelong ageing, yet human evidence is scarce. Using Britain’s postwar sugar rationing as a natural experiment, we examine its long-term effects in 64,809 United Kingdom Biobank participants. Exposure to sugar rationing during the first 1,000 da...