Boston University

Reframing HRM for a multipolar world: insights from the Asia-Pacific region

Purpose The purpose of this anthology is to critically evaluate the role of human resource management in International Business within an increasingly multipolar, digitally disrupted and institutionally diverse global environment. By bringing together leading scholars, the collec...

LATS1/2 inactivation drives a distinct venous endothelial cell response that contributes to fibrotic remodeling of the lung

Endothelial dysfunction is recognized to contribute to chronic tissue remodeling in the lung, yet endothelial-derived mechanisms driving these processes remain largely undefined. Here, we show that endothelial inactivation of the LATS1 and LATS2 kinases, key suppressors of the tr...

From AI Intuition to AI Literacy: A Dual Framework for K-12 Education

AI literacy has become a central framework for guiding the integration of artificial intelligence in K-12 education, emphasizing conceptual understanding, practical application, critical evaluation, and ethical judgment. These competencies are essential for supporting informed an...

Improving Primary Healthcare: Applying Grapevine (Vitis vinifera) Principles to Lebanon’s Vision 2030

Background/Objectives: While Lebanon’s Vision 2030 prioritizes strengthening Lebanon’s chronically constrained, fragmented, and shocked primary healthcare system, implementation is hindered by weak sensing mechanisms, misaligned spatial distribution, and poorly integrated referra...

Transcriptome signatures associated with cognitively unimpaired individuals with pathologically confirmed Alzheimer disease

There is growing interest in cognitive resilience to Alzheimer’s disease (AD), given limited success of therapies targeting hallmark proteins. Gene expression in the prefrontal cortex region obtained from brain donors in three cohorts was compared among pathological controls and...

Full-covariance chemical Langevin predator–prey diffusion with absorbing boundaries

Abstract Many stochastic predator–prey models introduce independent diagonal noise at the stochastic level. Such formulations are useful phenomenological models, but they do not explicitly encode the event-level coupling created by predation and biomass conversion. We derive an a...

Association of prenatal exposure to opioids, cannabis, and polysubstance use with cord blood DNA methylation patterns in a multiancestry cohort

Abstract Background: Blood DNA methylation patterns are highly predictive of prenatal exposure to smoking and differential methylation has been associated with maternal alcohol use. We extended this to determine whether DNA methylation patterns in cord blood are associated with p...

Algae-specific immune modulation influences responses to heat and pathogen challenge in a symbiotic coral

ABSTRACT The role of symbiotic algae in coral life history and host health is well documented, but the immune and physiological trade-offs of hosting these symbionts remain less explored. While association with the algal symbionts of the genus Durusdinium is known to confer therm...

Pregnancy after Hemithyroidectomy: Increased Risk of Gestational Overt Hypothyroidism Despite Favorable Obstetric Outcomes: A Nationwide Study

Background: To assess the association between preconception hemithyroidectomy and the risk of gestational hypothyroidism and obstetric outcomes. Methods: This nationwide population-based retrospective cohort study compared euthyroid pregnant women with a history of hemithyroidect...

Estimating Spatial and Temporal Patterns of Residential Power Outages in Massachusetts from 2013 to 2022 Using Public Records

Abstract Power outages are a growing threat to human health. Extreme weather events and strains on the electrical grid can cut off access to critical health-supporting medical equipment. However, the full scope of health impacts related to power outages has not been quantified, i...

“I Just Need Guidance Through This Maze I’m Going Through”: Addressing Unmet Basic and Mental Health Needs to Facilitate Engagement in HIV Prevention Services in the Context of Stimulant Use

There is a global syndemic of HIV, mental health challenges, substance use, and structural barriers. Critical to local HIV prevention efforts is understanding this syndemic in the context of rising stimulant use to inform intervention development. Adhering to the EPIS model, we c...

Computational Oncology of Chemotaxis-Driven Tumour–Immune Spatial Patterning and Stability

We develop a reaction–diffusion–chemotaxis model for spatial tumour–immune–chemokine dynamics that couples logistic tumour growth, immune-mediated killing, chemokine-dependent immune recruitment, chemotactic migration, and signal production. For the non-dimensional system, we est...

Isothermal Captureand Release of Carbon Dioxide witha Porous Molecular Hexaamine

Abstract The decarbonization of fossil fuel combustion streams and air is imperative to achieve negative carbon emissions and requires discovery of new materials that exhibit high CO2 capacities, long-term stability, and minimal energy input for the release of pure CO2. Numerous...

Isolated Diastolic Hypertension and Cardiovascular Disease Risk in Young Adults

BACKGROUND: Whether isolated diastolic hypertension (IDH) in young adults represents a benign, age-specific phenotype or confers increased cardiovascular disease risk remains uncertain. We assessed the associations between hypertension subtypes, IDH, isolated systolic hypertensio...

Gemfibrozil promotes longevity and health by restricting amino acid uptake through the Dipeptide transporter, PEPT1

The FDA-approved fibrate, gemfibrozil, has been used clinically to treat hyperlipidaemia, showing efficacy both in lowering triglycerides and increasing high-density lipoproteins. However, in recent years, the drug has been increasingly investigated for potential clinical use in...

Leveraging win time endpoint and combining moderators for personalized treatment recommendation in time-to-event clinical trials

Abstract Background There has been increasing interest in randomized trials on the discovery and identification of treatment moderators on an outcome. This reflects the stratified medicine paradigm, which moves beyond average treatment effects to focus on patient subgroups with h...

Distinct cortical spatial representations learned along disparate visual pathways

Recent experimental studies have discovered diverse spatial properties, such as head direction tuning and egocentric tuning, of neurons in the postrhinal cortex (POR) and revealed how the POR spatial representation is distinct from the retrosplenial cortex (RSC). However, how the...

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...

Alizarin Red perturbs skeletal patterning and biomineralization via catalase inhibition

Alizarin Red S (AZ) is an anthraquinone dye that is commonly used in histological studies and textiles. Exposure to AZ results in morphological perturbations in several species, including rats, frogs, and dogs; however, the mechanisms by which AZ has these effects is largely unex...

Proteomic analysis of human chronic traumatic encephalopathy brain implicates proteasome and ribosome dysfunction in disease severity

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that occurs in individuals with repeated head impacts (RHI) exposure, including contact sport athletes, military personnel, and domestic abuse victims. Despite growing recognition of CTE, the molecular mechanis...