Boston University

Effect of apremilast on entheseal bone damage in psoriasis patients at risk of developing psoriatic arthritis - data from the prospective, interventional EPOS study

BACKGROUND/PURPOSE: A subset of psoriasis (PsO) patients exhibits subclinical entheseal inflammation and bone remodeling placing them at higher risk of developing psoriatic arthritis (PsA). Whether early pharmacological interventions during this phase can modulate these inflammat...

The impact of structural variation on Alzheimer’s disease in the Alzheimer’s disease sequencing project

Structural variants (SV), genomic alterations spanning more than 50 base pairs, can significantly impact gene expression and protein function. However, their contribution to Alzheimer’s disease (AD) remains poorly understood. Leveraging a novel SV calling pipeline, we identified...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

Hyperpolarized [2– 13 C]Pyruvate Identifies a Mitochondria‐Active Hepatocellular Carcinoma Phenotype With Vulnerability to Mitochondrial Inhibition

ABSTRACT Hepatocellular carcinoma (HCC) exhibits metabolic heterogeneity that is not fully characterized by glycolysis‐focused spectroscopic profiling. This study investigated whether in vitro hyperpolarized (HP) [2‐ 13 C]pyruvate NMR spectroscopy can identify a mitochondria‐acti...

Glomerulus-Targeted Nanotherapy via Collagen IV-α3 Binding Enhances Renal Immunoregulation in Lupus Nephritis

Lupus nephritis requires long-term immunosuppressive therapy, which is often associated with severe systemic side effects. Therefore, new therapeutic strategies that maintain high efficacy while minimizing adverse effects is essential. Although nanomedicine has advanced systemic...

Endovascular Thrombectomy for Cerebral Venous Thrombosis: Current Status and Future Directions

Abstract Cerebral venous thrombosis (CVT) represents a relatively rare cause of stroke, yet it carries an overall rate of death or dependency of up to 15%. The mainstay of its management is therapeutic anticoagulation, either subcutaneously or intravenously in the acute phase, fo...

Increasing Respiration Weakens the Carbon Sink Over Two Decades in a Temperate Deciduous Forest

ABSTRACT Temperate deciduous forests have been major carbon sinks over the past century, largely due to regrowth following historical land use. However, the persistence of this sink is uncertain as forests age under global change. Using two decades (2004–2023) of eddy covariance...

Artificial Intelligence-Based Respiratory Sound Analysis: A Scoping Review of Digital Auscultation Technologies, Public Datasets, Signal Processing, and Deep Learning Methods

Respiratory sound analysis is becoming increasingly popular as a non-invasive method for detecting adventitious sounds and aiding in the diagnosis of respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, and pneumonia. However, studies in this field d...

Acyl-Alkyl-Phosphatidylcholine C40:6 is Potentially a Causal Biomarker for Obesity-Related Knee Osteoarthritis: Data from 4 Independent Cohorts

Objectives To identify potential causal biomarkers for obesity-related knee osteoarthritis (OB+OA+) by metabolome-wide association analysis (MWA) and Mendelian randomization (MR). Methods Four cohorts were included: the Newfoundland Osteoarthritis Study (NFOAS) as discovery, the...

COVID-19: Molecular Basis of Infection-ADAPTATION

<p><a href="https://molecular-casenet.rcsb.org/node/23">COVID-19: Molecular Basis of Infection</a></p> <p><em>Overview</em>: This case is an adaptation of the original COVID-19: Molecular Basis of Infection case which discusses how the SA...

Happy Blue Baby

<p><a href="https://molecular-casenet.rcsb.org/node/5">Happy Blue Baby</a></p> <p><em>Overview</em>: This case explores the reasons for why an otherwise healthy infant turned blue, soon after birth. All tests done in the neonatal intensiv...

Early life sugar rationing and ageing related diseases, biological ageing and mortality

Early-life nutrition may influence lifelong ageing, yet human evidence is scarce. Using Britain’s postwar sugar rationing as a natural experiment, we examine its long-term effects in 64,809 United Kingdom Biobank participants. Exposure to sugar rationing during the first 1,000 da...

Mechanisms of Association of Maternal Education and Intent to Vaccinate Children Against COVID-19

BACKGROUND Although higher maternal education is positively associated with many child health–promoting practices, it is more complicated for child vaccination, and the explanatory mechanisms remain unclear. We aimed to examine mechanisms underlying the association of maternal ed...