Boston University

Assessing the effectiveness of podcasts in supporting occupational therapy career readiness

Background Preparing occupational therapy students for emerging practice areas (E/IPA) requires scalable strategies to build career readiness beyond traditional clinical training. While podcasts show promise for career exploration, their efficacy in fostering OT career preparedne...

Facile Gram-Scale Solution Phase Synthesis of a Universal Cathepsin B-Cleavable Antibody-Drug Conjugate Linker

Abstract Antibody drug conjugates (ADCs) are a key therapy in the cancer treatment arsenal. Critical to the success of the ADC is the release of the drug cargo at the desired site, and thus, enzymatically or chemically responsive linkers, connecting the drug to the antibody, play...

Surface Quadrilateral Meshing from Integrable Odeco Fields

Abstract We present a method for generating orthogonal quadrilateral meshes subject to user‐defined feature alignment and sizing constraints. The approach relies on computing integrable orthogonal frame fields, whose symmetries are implicitly represented using orthogonally decomp...

Cervical Disc Arthroplasty: Evolution, Evidence, and Future Directions in Motion-Preservation Surgery

➢ Cervical disc arthroplasty (CDA) provides clinical outcomes comparable with those of anterior cervical discectomy and fusion (ACDF) for 1-level and 2-level cervical degenerative disc disease (DDD), with durable long-term motion preservation. ➢ Although CDA is associated with lo...

Recent and Cumulative Cannabis Use and Sleep in Middle-Aged Adults

Importance Cannabis is widely used and often promoted as a sleep aid, but evidence of its long-term implications for sleep is limited. Objective To examine the associations of cumulative cannabis exposure from young adulthood to middle age and recent cannabis use with objective a...

Surgical Management Patterns and Outcomes in Recurrent Corneal Erosion: An IRIS Registry Study

PURPOSE: Surgical management of recurrent corneal erosion (RCE) lacks large-scale evidence, and national patterns of care and procedural outcomes remain incompletely defined. We characterized national practice patterns, repeat surgery rates, and risk factors for surgical failure...

A Community-Based Behavioral Intervention and Body Mass Index in School-Aged Children

Importance Childhood obesity remains a major concern in the US, with increases in body mass index (BMI) observed during and after the COVID-19 pandemic. Scalable behavioral interventions are needed to support obesity prevention in community settings. Objective To evaluate the eff...

The Composite Spectrum of QSO Absorption Line Systems in DESI DR2

Abstract We present details regarding a composite spectrum of quasar (QSO) absorption line systems. In this composite spectrum, we identify more than 70 absorption lines and observe oxygen and hydrogen emission features at a higher signal-to-noise ratio than any previous study. A...

The silent pandemic: the overlooked toll of stroke compared to COVID-19

The COVID-19 pandemic will be remembered as one of the defining health crises of the modern era. The World Health Organization reported approximately 7 million deaths attributed to COVID-19 globall...

Intellectual humility and eudaimonic well-being among emerging religious/spiritual leaders

Religious/spiritual leaders remain an understudied at-risk population for lower eudaimonic well-being. We explored the potential for intellectual humility to promote greater eudaimonia with divine struggles as a mediator. We used a diverse sample of leaders obtaining graduate the...

Tailored speckle illumination microscopy with enhanced sectioning and image quality

Optical speckle patterns have been widely used for illumination in computational imaging, optical sectioning microscopy, and superresolution imaging. However, commonly used speckles satisfy Rayleigh statistics, which are not ideal for diverse imaging applications. Here we tailor...

Entity-centric evaluation of large language model responses for medical question-answering tasks

Large language models (LLMs) are increasingly evaluated for clinical question-answering (QA) tasks, yet benchmark accuracy alone provides limited assurance of clinical reliability. Existing evaluation metrics often fail to capture whether model reasoning preserves patient-specifi...

Constraints on new theories using Rivet: CONTUR version 3 release note

The CONTUR toolkit exploits RIVET and its library of more than a thousand energy-frontier differential cross-section measurements from the Large Hadron Collider to allow rapid limit-setting and consistency checks for new physics models. In this note we summarise the main changes...

Formation of a swelling gel underlies a morphological transition in Bacillus subtilis biofilms

Microbes across diverse species and environments form biofilms, living materials composed of cells and extracellular polymers. Biofilm-dwelling cells benefit from emergent soft matter physics, which sculpts three-dimensional morphologies and facilitates osmotic nutrient uptake. A...

Developmental trajectories of tonic and phasic irritability from ages 12 to 21: early predictors, co‐development, and psychiatric outcomes in young adulthood

Background Irritability is a common and impairing, transdiagnostic feature of youth psychopathology. Theory distinguishes tonic irritability (persistent irritable mood) from phasic irritability (episodic temper outbursts), yet little is known about how these dimensions co‐develop...

Cosmogenic 10 Be as a Tracer for Recent Heliospheric Encounters With Interstellar Cold Clouds and Nearby Supernovae

Abstract Recent works suggest there are periods when the Sun encountered massive interstellar cold clouds which compressed the heliosphere to within Earth's orbit, exposing Earth to interstellar galactic cosmic rays and energetic particles of heliospheric origin. We model 10 Be p...

Pharmacokinetics of Efavirenz in Pregnancy and Postpartum with and Without First-line Tuberculosis Drugs: Results from IMPAACT P1026s

Efavirenz (EFV) pharmacokinetics (PK) may be influenced by both pregnancy-related physiological changes and concurrent treatment for drug-sensitive tuberculosis (DS-TB), and intensive 24-h EFV PK data during rifampin (RIF)/ isoniazid (INH) treatment in pregnant women living with...

Spike antibody Fc is associated with protection from SARS-CoV-2 challenge in macaques

A definitive correlate of protection (CoP) for SARS-CoV-2 has yet to be formally established. We previously reported that neutralising antibodies (NAbs) are the strongest candidate CoP for clinical protection against COVID-19 and that spike binding antibody is the strongest candi...

Culture-Agnostic and Culture-Specific Analyses of Semantic Fluency in Korean and English Speakers With Alzheimer's Disease

PURPOSE: This study investigated cross-linguistic and cultural influences on semantic fluency in monolingual Korean- and English-speaking individuals with Alzheimer's disease (AD) by contrasting culture-agnostic and culture-specific analytic frameworks. We focused on how cultural...

Rebalancing Frequency Dominates Risk-Proxy Choice: A Comparison of Mean–Variance, MAD, and Quantile-Constrained Portfolios of U.S. Sector ETFs

Practitioners choosing among risk measures for portfolio construction face a real question: does the choice of risk proxy—variance, mean absolute deviation (MAD), interquartile range (IQR), or a wider central-quantile measure—actually change portfolio outcomes, or does it get swa...