Boston University

Estimating Spatial and Temporal Patterns of Residential Power Outages in Massachusetts from 2013 to 2022 Using Public Records

Abstract Power outages are a growing threat to human health. Extreme weather events and strains on the electrical grid can cut off access to critical health-supporting medical equipment. However, the full scope of health impacts related to power outages has not been quantified, i...

“I Just Need Guidance Through This Maze I’m Going Through”: Addressing Unmet Basic and Mental Health Needs to Facilitate Engagement in HIV Prevention Services in the Context of Stimulant Use

There is a global syndemic of HIV, mental health challenges, substance use, and structural barriers. Critical to local HIV prevention efforts is understanding this syndemic in the context of rising stimulant use to inform intervention development. Adhering to the EPIS model, we c...

Computational Oncology of Chemotaxis-Driven Tumour–Immune Spatial Patterning and Stability

We develop a reaction–diffusion–chemotaxis model for spatial tumour–immune–chemokine dynamics that couples logistic tumour growth, immune-mediated killing, chemokine-dependent immune recruitment, chemotactic migration, and signal production. For the non-dimensional system, we est...

Isothermal Captureand Release of Carbon Dioxide witha Porous Molecular Hexaamine

Abstract The decarbonization of fossil fuel combustion streams and air is imperative to achieve negative carbon emissions and requires discovery of new materials that exhibit high CO2 capacities, long-term stability, and minimal energy input for the release of pure CO2. Numerous...

Isolated Diastolic Hypertension and Cardiovascular Disease Risk in Young Adults

BACKGROUND: Whether isolated diastolic hypertension (IDH) in young adults represents a benign, age-specific phenotype or confers increased cardiovascular disease risk remains uncertain. We assessed the associations between hypertension subtypes, IDH, isolated systolic hypertensio...

Gemfibrozil promotes longevity and health by restricting amino acid uptake through the Dipeptide transporter, PEPT1

The FDA-approved fibrate, gemfibrozil, has been used clinically to treat hyperlipidaemia, showing efficacy both in lowering triglycerides and increasing high-density lipoproteins. However, in recent years, the drug has been increasingly investigated for potential clinical use in...

Leveraging win time endpoint and combining moderators for personalized treatment recommendation in time-to-event clinical trials

Abstract Background There has been increasing interest in randomized trials on the discovery and identification of treatment moderators on an outcome. This reflects the stratified medicine paradigm, which moves beyond average treatment effects to focus on patient subgroups with h...

Alizarin Red perturbs skeletal patterning and biomineralization via catalase inhibition

Alizarin Red S (AZ) is an anthraquinone dye that is commonly used in histological studies and textiles. Exposure to AZ results in morphological perturbations in several species, including rats, frogs, and dogs; however, the mechanisms by which AZ has these effects is largely unex...

PLCG2 downregulation impairs synaptic function and increases Alzheimer’s disease hallmarks in neuronal cultures

We developed a high-content screening to investigate how Alzheimer’s disease (AD) genetic risk factors may affect synaptic mechanisms in rat primary neuronal cultures. Of the target genes identified, we found that Plcg2 downregulation in mouse dentate gyrus neurons consistently d...

Distinct cortical spatial representations learned along disparate visual pathways

Recent experimental studies have discovered diverse spatial properties, such as head direction tuning and egocentric tuning, of neurons in the postrhinal cortex (POR) and revealed how the POR spatial representation is distinct from the retrosplenial cortex (RSC). However, how the...

Proteomic analysis of human chronic traumatic encephalopathy brain implicates proteasome and ribosome dysfunction in disease severity

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease that occurs in individuals with repeated head impacts (RHI) exposure, including contact sport athletes, military personnel, and domestic abuse victims. Despite growing recognition of CTE, the molecular mechanis...

Preferential CDR masking in paired antibody language models improves binding affinity prediction

Therapeutic antibodies are a leading class of biologics, yet their unique architecture poses challenges for computational modeling. Each antibody comprises paired heavy and light variable domains with conserved framework regions that maintain structure and hypervariable complemen...

Cedalion tutorial: a Python-based framework for comprehensive analysis of multimodal fNIRS and DOT from the lab to the everyday world

Functional near-infrared spectroscopy (fNIRS) and diffuse optical 1 tomography (DOT) are rapidly evolving toward wearable, multimodal, data-driven, and artificial-intelligence-supported neuroimaging in the everyday world. However, current analytical tools are fragmented across pl...

Suffering, Trauma, and Relational Integration: Re-Envisioning Spiritual Care and Psychoanalysis in a Decolonial Age

Spiritual care is summoned by suffering—by ‘wounds’ that are psychological, relational, spiritual, embodied, and political at once. As disciplines continue to be entrenched and siloed amidst the growing sociopolitical tensions and global crises in a decolonial age, what is at sta...

Discretionary Child Protective Services Reporting for Infants With Prenatal Opioid Exposure

OBJECTIVE Hospital guidelines implemented in May 2021 to end reflexive child protective services (CPS) reporting for infants with prenatal substance exposure nearly halved overall reporting rates among infants with prenatal opioid exposure (IPOE). Given concerns that discretionar...

Room-temperature multiferroicity in all–van der Waals heterostructures

Multiferroics host simultaneous and coupled ferroic orders, allowing disparate external stimuli to induce abrupt transformations in their structures and properties. Creating multiferroicity in two-dimensional (2D) van der Waals (vdW) platforms would add the elements of strong qua...

Association of Accelerated Biological Age in Midlife with Cardiovascular Events, Dementia, and All-Cause Mortality in the Framingham Offspring Study

Accelerated biological age (ABA) better capture the aging process than chronological age (CA) and has been linked to adverse health outcomes, but long-term associations remain unclear. We modeled ABA using anthropometric and biochemical biomarkers across three examination cycles...

Association between urbanicity–cooking fuel type and self-reported respiratory symptoms as a proxy for acute respiratory infection symptoms among children under two years across ten East African countries

Abstract Introduction Evidence remains limited on how urbanicity modifies the relationship between household cooking fuel type and respiratory symptoms in young children in low- and middle-income countries (LMICs). This study examined the prevalence of cough and dyspnea across te...

Self‐attributing religious knowledge

People regularly profess belief in religious ideas. But do they merely think of themselves as believing, or do they think of themselves as possessing knowledge ? I first argue that it is difficult to determine this based purely on religious people's self‐descriptions. I instead a...

Money, Meals, and Marketing in Medicine: A 13‐Year Follow‐Up Survey of Physicians

Pharmaceutical company marketing to physicians is known to impact prescribing patterns. In 2011, we surveyed medical students and residents about physician/industry relationships. In 2024, we resurveyed the same participants to study changes in their behaviors over time and their...