Beth Israel Deaconess Medical Center

PrEP reinitiation, uptake, and persistence as targets for reducing HIV incidence and racial and ethnic inequities among men who have sex with men in Boston, USA: a network modeling study

Background A decade of pre-exposure prophylaxis (PrEP) has lowered HIV incidence among men who have sex with men (MSM) but not enough to meet Ending the HIV Epidemic goals, and racial and ethnic disparities persist. The PrEP era has produced a population of former users facing lo...

Extended Follow-Up of Botensilimab Plus Balstilimab in an Expanded Cohort of Microsatellite-Stable Metastatic Colorectal Cancer Without Active Liver Metastases

PURPOSE: Microsatellite-stable metastatic colorectal cancer (MSS mCRC) has limited treatment options and responds poorly to conventional immunotherapy. We report extended follow-up results from a fully-enrolled, phase 1b cohort evaluating botensilimab (BOT; Fc-enhanced anti-CTLA-...

Woven endobridge device compared to stent-assisted coiling and microsurgical clipping for intracranial aneurysms

Background: Endovascular techniques and devices, including Woven EndoBridge (WEB) and stent-assisted coiling (SAC), expand the choice of therapies for complex aneurysms, while the evidence directly comparing them to microsurgical clipping (MSC) remains very limited. This meta-ana...

The importance of classifying central hypopneas: a call to action

Obstructive and central sleep apnea share pathophysiologic features and often coexist within individual patients. There is general agreement on the criteria for scoring obstructive and central apneas but less guidance and clarity on how and when to classify obstructive and centra...

Fusion-driven oncogenic programs shape the immune landscape in translocation renal cell carcinoma

Renal cell carcinomas comprise multiple molecularly distinct cancers but most are treated empirically with therapies designed for clear cell RCC (ccRCC), the most common subtype, due to incomplete understanding of subtype-specific biology. We analyzed single-cell transcriptomes a...

Public Access, Open Access, and the Need for NIH Governance

This Viewpoint discusses the confusion between public access and open access, pay-to-comply publisher practices, and the steps that the National Institutes of Health (NIH) must take to fill this gap and promote public access goals.

Early gastric carcinoma with lymphoid stroma associated with a low risk of lymph node metastasis and favorable prognosis: a multicenter study in a Chinese population

Abstract Objective Gastric carcinoma with lymphoid stroma is a rare subtype of gastric carcinoma. The clinicopathological features and prognosis of early gastric carcinoma with lymphoid stroma (EGCLS) remain elusive, especially in Chinese populations. Methods In this study, we in...

Management of Acute Pulmonary Embolism in a Patient With Hereditary Factor X Deficiency

All authors declare that they have no conflicts of interest. The data that support the findings of this study are available from the corresponding author upon reasonable request.

Modern endoscopic strategies for the diagnosis and management of cholangiocarcinoma

Cholangiocarcinoma (CCA) presents considerable diagnostic and therapeutic challenges for the endoscopist. This review offers a focused and practical evaluation of contemporary endoscopic approaches for the diagnosis and management of CCA, with an emphasis on real-world applicabil...

Study protocol for first national vasa previa perinatal registry

Vasa previa is a rare but potentially catastrophic obstetric condition characterized by unprotected fetal blood vessels over or adjacent to the internal cervical os. Although advances in prenatal ultrasound have dramatically improved neonatal survival through planned cesarean del...

Decoding the causes of ischemic stroke despite ongoing oral anticoagulation and their clinical impact: the ASPERA-R study

BACKGROUND: Oral anticoagulants (OACs), including vitamin K antagonists and direct OACs, reduce stroke risk in atrial fibrillation (AF), yet breakthrough ischemic stroke still occurs in 1-2% of patients annually despite adequate therapy. The mechanisms underlying these events rem...

Continuing Trend of Increased Operative Treatment of Clavicle Fractures in Pediatric Patients in the United States Despite a Lack of Supporting Evidence in the Literature

Introduction: Pediatric clavicle fractures are among the most common fractures in this age group. Current research supports the efficacy of nonoperative treatment for these injuries in pediatric patients. Our study seeks to examine the current trends in the management of these fr...

Discretionary Child Protective Services Reporting for Infants With Prenatal Opioid Exposure

OBJECTIVE Hospital guidelines implemented in May 2021 to end reflexive child protective services (CPS) reporting for infants with prenatal substance exposure nearly halved overall reporting rates among infants with prenatal opioid exposure (IPOE). Given concerns that discretionar...

Advocacy around abortion in a politically charged climate

PURPOSE OF REVIEW: To examine the evolving role of clinician advocacy in abortion care and to highlight key domains through which obstetrician-gynecologists can influence policy, clinical practice, and patient outcomes. RECENT FINDINGS: Increasing state-level abortion restriction...

No association between smoking and obstructive sleep apnea in men: evidence from middle-aged adults followed into later life

RATIONALE: The relationship between smoking and obstructive sleep apnea (OSA) remains unclear. Observational findings have been inconsistent, and associations may vary depending on study population, design, measurements. OBJECTIVES: To evaluate the cross-sectional and longitudina...

The Role of Assignment in Defining and Identifying Causal Effects in Randomized Trials

In randomized trials, the per-protocol effect is defined as the effect of being assigned a treatment strategy and receiving treatment according to the assigned strategy; therefore, it encompasses the effect of the treatment strategy and any effect of assignment that does not oper...

Right hippocampal volume and attenuated psychotic symptoms distinguish subgroups of youth with common patterns of temporoparietal effective connectivity

Abstract Associations between patterns of brain connectivity and brain structural features have transdiagnostic relevance to psychopathology. There is considerable evidence for disruptions to the hippocampus and temporoparietal brain systems in psychotic disorders. The present st...

Hyperpolarized [2– 13 C]Pyruvate Identifies a Mitochondria‐Active Hepatocellular Carcinoma Phenotype With Vulnerability to Mitochondrial Inhibition

ABSTRACT Hepatocellular carcinoma (HCC) exhibits metabolic heterogeneity that is not fully characterized by glycolysis‐focused spectroscopic profiling. This study investigated whether in vitro hyperpolarized (HP) [2‐ 13 C]pyruvate NMR spectroscopy can identify a mitochondria‐acti...

A compendium of next-generation patient-derived models for diverse cancers

Abstract The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2–4 . Recent technologies have enable...

Effects of remote ischemic preconditioning on intestinal oxygenation, microcirculation, and mitochondrial respiration within the second window of organ protection in a rodent hemorrhagic shock model

Abstract Background In the setting of high-risk surgery, preventive strategies to maintain intestinal tissue integrity are of particular importance, as no bridging organ replacement therapy exists. Remote ischemic preconditioning (RIPC) has been reported to attenuate organ injury...