Beth Israel Deaconess Medical Center

Big data and psychiatry: advances, constraints and future directions.

Early work in psychiatry research, often involving single sites, small samples, and limited variables, has shifted to contemporary research involving multiple sites, large samples, and many variables. Such research raises important questions, including concerns about data quality...

Effects of Abortion Bans on the Physician Workforce.

OBJECTIVE: To examine physicians' experiences providing early pregnancy care under abortion bans and perspectives on how these bans affect the reproductive health workforce. METHODS: From May 2024 to May 2026, we conducted semistructured interviews with obstetrician-gynecologists...

Sex, Drugs, and the Language of Donor Narratives: Associations With Kidney Acceptance.

Background: Despite the shortage of donor kidneys, nonutilization remains common. We hypothesized that social history language in donor narratives influences acceptance. Using Natural Language Processing, we evaluated how language describing high-risk behaviors interacts with obj...

Preconception, Prenatal and Postnatal PM2.5 Exposure and Neurodevelopmental Disorder Risk among Medicaid Recipients

Abstract Evidence linking ambient fine particulate matter (PM2.5) exposure to childhood neurodevelopmental disorders (NDDs) remains mixed. We conducted a cohort study (2001–2013) of 1,547,244 Medicaid-enrolled mother-child pairs to assess associations between zip-code–level PM2.5...

Coblation Versus Microdebrider in Pediatric Intracapsular Tonsillotomy: A Comparison of Efficiency, Bleeding, and Revision Surgery

OBJECTIVE: Intracapsular tonsillectomy or "tonsillotomy" is an increasingly popular alternative to extracapsular tonsillectomy due to decreased bleeding risk and pain. Coblation and microdebrider are most frequently used, but studies comparing them are limited. We aimed to compar...

Experimental model of ventilator-induced lung injury induces proteomic signatures of neurodegeneration in the hippocampus

Abstract Background Mechanical ventilation is associated with acute and long-term cognitive dysfunction, yet the molecular pathways linking ventilator-induced lung injury (VILI) to brain injury remain poorly characterized. We previously demonstrated that peripheral IL-6 signaling...

Can We Diagnose Early Melanoma by Genomics?

Melanoma incidence has increased approximately 6-fold over the past 40 years, driven primarily by melanoma in situ and thin invasive melanomas, which are among the most subjective lesions to diagnose on histopathology. This review examines whether genomics clarifies the "gray zon...

Top Ten Tips Palliative Care Clinicians Should Know About Collaborating with Consultation-Liaison Psychiatry

Palliative care (PC) and consultation-liaison (CL) psychiatry are complementary clinical disciplines that frequently care for the same patients facing serious illness complicated by psychiatric symptoms, psychological distress, neuropsychiatric syndromes, and high-stakes medical...

Maternal and Fetal Outcomes in Mice Following Exposure to Dolutegravir Alone or in Combination with Lamivudine or Tenofovir Disoproxil Fumarate/Emtricitabine

Abstract Background and Aims Dolutegravir (DTG)-based regimens are widely used in HIV treatment, including during pregnancy, but the contribution of the nucleoside reverse transcriptase inhibitor (NRTI) backbone on maternal and foetal outcomes remains unclear. We examined this in...

Safety and Efficacy of Left Atrial Ablation After Percutaneous Left Atrial Appendage Occlusion in High-Bleeding-Risk Patients with Atrial Fibrillation: A Multicenter Analysis from the PROCEED-AF Ablation Registry

BACKGROUND AND AIMS: Patients with left atrial appendage (LAAO) devices are increasingly referred for AF ablation, yet anticoagulation strategies remain uncertain. The goal of this study was to evaluate the safety and efficacy of catheter ablation for atrial fibrillation (AF) in...

Baseline preparedness and evaluation of a blended disaster medicine course among medical students at Yarmouk University, Jordan

Disasters, including armed conflicts, pandemics, and natural hazards, pose major challenges to healthcare systems and require a well-prepared healthcare workforce. However, disaster medicine remains insufficiently integrated into many undergraduate medical curricula. This study a...

HSP90 shields ROC1/RBX1 from proteasomal degradation by CHIP E3 ubiquitin ligase to promote lung adenocarcinoma

The Regulator of Cullins 1 (ROC1) or RING box protein-1 (RBX1) is an essential component of the largest multiunit Cullin-RING ubiquitin ligase (CRL). Previous studies demonstrated that ROC1 is frequently overexpressed in multiple malignancies, which predicts advanced cancer stage...

Screening strategies for colorectal cancer: adjusting for individual risk factors

INTRODUCTION: Colorectal cancer (CRC) is a common cause of cancer-related mortality. While overall incidence has declined, certain populations - particularly younger patients - have experienced a rise. This suggests a more complex risk profile than the dichotomous average vs high...

m6A mRNA methylation regulates pancreatic α-cell plasticity

Pancreatic α-cells are central regulators of glucose and amino acid homeostasis, yet the mechanisms that preserve α-cell identity and function remain incompletely understood. N6-methyladenosine (m6A) is a widespread mRNA modification that is essential for β-cell biology and pancr...

Five-Year Cost-Effectiveness Analysis of Endoscopic Third Ventriculostomy With Choroid Plexus Cauterization Versus Ventriculoperitoneal Shunting in Postinfectious Hydrocephalus in a Low-Income Setting

BACKGROUND AND OBJECTIVES: For over 2 decades, an emerging body of data has established endoscopic third ventriculostomy with choroid plexus cauterization (ETV/CPC) as a viable option in the treatment of postinfectious hydrocephalus (PIH) in low-resource settings with similar out...

Influence of Chronic Kidney Disease on Outcomes After Paclitaxel-Coated Balloon Angioplasty for Coronary In-Stent Restenosis

BACKGROUND: Drug-coated balloons (DCB) are superior to conventional balloon angioplasty in coronary in-stent restenosis. The influence of chronic kidney disease (CKD) on outcomes after DCB for in-stent restenosis is not well described. METHODS: A post hoc analysis of the AGENT ID...

M3: Conversational LLMs simplify secure clinical data access, understanding, and analysis

Large-scale clinical databases offer opportunities for medical research, but their complexity creates barriers to effective use. The Medical Information Mart for Intensive Care (MIMIC-IV), one of the world’s largest open-source electronic health record databases, traditionally re...

A medically grounded LLM agent–based tool to detect patient safety events in medical records

Large language models (LLMs) have shown incredible promise in medicine. While LLMs may be particularly useful in areas requiring extensive review of clinical records, their use remains limited due to their tendency to hallucinate and fabricate information. Hallucination issues, a...

High-grade astrocytoma with piloid features: a clinical and genomic analysis of prognostic factors using a large cohort

BACKGROUND: High-grade astrocytoma with piloid features (HGAP) is a recently defined tumor type that is not well-understood. Prognostic factors of clinical outcomes are not well-established. METHODS: Methylation profiling was performed on tumor samples, many at the National Cance...

Auditing sex/gender disparities in emergency triage with LLM-based paired comparisons

We present a domain-agnostic paired-comparison approach that uses Large Language Models (LLMs) to quantify sex/gender-related asymmetries in documented clinical decision-making. The method trains an LLM to emulate observed decisions, then evaluates sex-swapped pairs in which only...