All India Institute of Medical Sciences

Magnetic Resonance Imaging Evaluation of Meniscal Ramp Lesions and their Association with Anterior Cruciate Ligament Injury Severity: A Retrospective Observational Study

Abstract Background: Meniscal ramp lesions are frequently associated with anterior cruciate ligament (ACL) injuries and are often overlooked on magnetic resonance imaging (MRI). Their relationship with the severity of ACL injury remains incompletely understood. Objective: The pur...

When pancytopenia meets the retina: Bilateral central retinal vein occlusion in idiopathic aplastic anemia

Bilateral central retinal vein occlusion (CRVO) is an uncommon condition that often results from systemic causes, including hematologic neoplasms, hyper viscosity states, and thrombophilia. Bilateral CRVO as a complication of idiopathic aplastic anemia is exceedingly rare. We pre...

Biomarkers in Irritable Bowel Syndrome: Bridging Gut–Brain Mechanisms to Precision Care

Abstract Purpose of Review Irritable bowel syndrome is a common disorder of gut-brain interaction characterized by chronic abdominal pain and altered bowel habits in the absence of structural pathology. Its pathophysiology reflects a complex interplay between the central nervous...

Metacognitive team-based learning for creative problem-solving in Indian medical undergraduates: a single-arm pre-post quasi-experimental mixed-methods study

Abstract Background Metacognitive and team-based strategies can strengthen problem-solving; however, many Indian medical undergraduates remain reliant on rote memorisation with limited exposure to structured, creativity-focused pedagogy. Structured interventions combining metacog...

Multi-target Therapy with Rituximab plus Mycophenolate Mofetil versus Rituximab Monotherapy in Systemic Sclerosis–Associated Interstitial Lung Disease

Objective To compare the effectiveness and safety of rituximab (RTX) plus mycophenolate mofetil (MMF) versus RTX monotherapy in patients with SSc-ILD. Methods We performed a retrospective comparative analysis among adults with radiologically confirmed SSc–ILD treated with rituxim...

A novel closed book parenchyma sparing technique for giant pulmonary hydatid cysts

BACKGROUND: Giant pulmonary hydatid cysts (GHCs), defined as cysts measuring ≥10 cm, pose significant surgical challenges owing to their large size and distortion of the native lung architecture, which often limits the effectiveness of conventional capitonnage. This study evaluat...

Fatal infantile encephalopathy due to NAXE variant: Navigating the Metabolic-Mitochondrial overlap in NAXE gene

Abstract Background Progressive Encephalopathy with Brain Edema and/or Leukoencephalopathy-1 (PEBEL-1) is a rare, rapidly progressive, and often fatal infantile neurometabolic disorder caused by pathogenic variants in the NAXE gene. Loss of NAXE impairs the NAD(P)HX repair pathwa...

Interstitial lung disease in pregnancy

Interstitial lung disease (ILD) comprises a heterogeneous group of chronic pulmonary disorders. ILD is associated with impaired gas exchange and progressive respiratory dysfunction. Due to improved survival and delayed childbearing, healthcare providers increasingly encounter pre...

Systematic review of medical audits of hysterectomy practices in India

Background and objectives The utilisation of hysterectomy has emerged as a public health concern in India. The Ministry of Health’s National Guidelines aim to reduce unnecessary hysterectomies by promoting adherence to recommended indications, age, and extent of surgery. Although...

Comparative Evaluation of the Efficacy of C-MAC™, McGrath MAC™ Videolaryngoscopes, and the Direct Miller Laryngoscope for Neonatal Intubation under General Anesthesia

BACKGROUND: Neonatal endotracheal intubation remains technically challenging due to small airway dimensions and limited glottic visualization. Identifying the most effective device and technique to secure the airway is crucial. Video laryngoscopes (VLs) have been introduced to en...

Foreign body–associated maxillary sinus aspergillosis caused by Endomethasone extrusion: diagnostic challenges, biological mechanisms, and surgical management

Extrusion of endodontic sealers into the maxillary sinus is an uncommon but clinically significant complication, particularly when biologically active zinc oxide–eugenol–based materials are involved. Their persistence within the sinus may impair mucociliary clearance and sustain...

Artificial Intelligence in the Peer Review of Orthopaedic Manuscripts: Current Applications, Limitations, and Policy Considerations

Peer review ensures the validity and clinical applicability of orthopaedic research. Advances in artificial intelligence (AI) have expanded its role in editorial workflows, including manuscript screening. However, its application in peer review raises ethical, scientific, and pro...