All India Institute of Medical Sciences

Diagnostic accuracy of high-risk HPV DNA and cytology in diagnosing precancerous and early malignant cervical lesions: a protocol for a systematic review and meta-analysis

Persistent infection with high-risk hr-HPV is a major cause in the aetiopathogenesis of cervical cancer. Early detection by screening is the best strategy for prevention. Two major screening techniques hr-HPV DNA and Pap smear, target the disease condition at two different timepo...

Multicomponent Self-Help Intervention Package for Fatigue, Quality of Life, Functional Performance and Aerobic Capacity during Cancer Chemotherapy: A Randomised Controlled Trial

Objectives: Fatigue ranks as a highly prevalent and distressing symptom stated by patients undergoing chemotherapy and/or radiation therapy. It significantly compromises the patients’ quality of life (QoL) and functional performance. The objective of this prospective trial was to...

Biomarker Insights into Diabetic Foot Ulcers: Evaluating Pentraxin-3 and Netrin-1 for Diagnosis and Clinical Associations

AimTo measure serum levels of Pentraxin-3 (PTX-3) and Netrin-1 in diabetic patients with and without foot ulcers and determine how these levels relate to clinical features, glycemic control, and ulcer status.MethodsIn this cross-sectional study, 80 patients were divided into thre...

Knowledge and perception regarding influenza and its vaccine among the elderly population in India: a multicentric study on the drivers of vaccine uptake

Older adults experience a high risk of severe influenza, yet vaccine uptake in India is low. There is no government funded influenza vaccination program in India. Understanding the drivers of uptake is essential to guide policy and practice. We conducted a multicentre, cross-sect...

Minimally invasive surgical therapies (MIST) for benign prostatic hyperplasia: Initial single-center experience

Background: Minimally invasive surgical therapies (MIST) have emerged as effective alternatives to transurethral resection of the prostate for the management of benign prostatic hyperplasia (BPH), offering symptomatic relief with reduced morbidity and preservation of sexual funct...

Miller's Pyramid: Origin, Application, Advantages, Disadvantages, and Impact in Forensic Pathology Teaching

Introduction Competency-based medical education (CBME) emphasizes demonstrable competencies rather than time-based training. Miller's Pyramid remains an influential framework for conceptualizing clinical competence, but its contemporary application in forensic pathology education...

Caught in the Publication Maze: Young Indian Researchers’ Perspectives

For many young medical researchers, the challenge of publication does not arise only at the stage of writing a manuscript; it develops much earlier in the research process. Difficulty in refining a feasible question, designing a methodologically sound study, managing research alo...

Recognizing and Addressing Fertility Issues among Childhood Cancer Patients and Survivors in India – A Multi Stakeholder Position Statement and Call to Action

Abstract Survival rates in childhood and adolescent cancers have improved substantially over the past decades, leading to a growing population of long-term survivors. In India, an estimated 76,000 children and adolescents are diagnosed with cancer annually, and approximately one-...

SpineXR-VQA: A Clinically-Validated Visual Question Answering Dataset for Spine X-Rays

Recent progress in Medical Visual Question Answering (VQA) has significantly aided clinical decision-making across various domains such as pneumonia, oncology, and neurology. However, spinal and musculoskeletal ailments remain critically underexplored. The development of reliable...

Artificial intelligence in medicine: a cross-sectional study of knowledge and attitudes

Abstract Background: Artificial intelligence (AI) holds promise in reshaping healthcare by transforming educational patterns, patient care, and research opportunities. However, there are obstacles impeding the proper integration of AI into the medical field. This study was undert...

Neurobehavioral Evaluation of Renin-Angiotensin System Modulators in an MPTP-Induced Model of Parkinson’s Disease in Swiss Albino Mice

BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor and nonmotor deficits. Emerging evidence suggests a role of the renin-angiotensin system (RAS) in neurodegeneration, making it a potential therapeutic target. AIM: To evaluate...

Success Rate and Factors Affecting Stability of Buccal Shelf Miniscrew Implants in Orthodontic Patients: A Systematic Review and Meta‐Analysis

ABSTRACT The primary role of buccal‐shelf miniscrew implants (BS‐MSI) in orthodontic treatment is to provide extra‐alveolar anchorage that alleviates severe crowding and allows for distalization of the entire mandibular arch and may obviate the need for orthognathic surgery, part...

Technology and Obesity: A Year in Review

SMART technological advancements help diagnose, treat, and monitor various diseases at the earliest stages. It presents an opportunity to maintain the key components of conventional obesity management programming while reducing costs and provider time inputs. Various machine lear...

Prognostic Value of Native T1 Mapping in Nonischemic Dilated Cardiomyopathy: A Prospective Observational Study from India

Abstract Native T1 mapping can detect diffuse myocardial fibrosis in nonischemic dilated cardiomyopathy (NIDCM), which may not be visible on late gadolinium enhancement (LGE) imaging. We assessed the prognostic relevance of native T1 mapping and its incremental value over LGE in...

AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for medulloblastomas and other embryonal tumors

WHO CNS5 mandates integrated histo-molecular classification of medulloblastomas (MBs) and other CNS embryonal tumors. However, advanced molecular diagnostics remain inaccessible in many low- and lower-middle-income countries (LICs/LMICs), limiting implementation of molecularly in...

Assessing the Feasibility of Adequate Anticoagulation With Unfractionated Heparin When Administered based on Lean Body Weight in Adult Patients Undergoing Open Heart Surgeries - A Prospective Cohort Study

Objectives: Weight-based unfractionated heparin (UFH) dosing before cardiopulmonary bypass (CPB) may overestimate requirements in patients with lesser lean body weight. We evaluated the feasibility of lean body weight (LBW)-based heparin dosing to achieve a target activated clott...

Asian Neurogastroenterology and Motility Association and Asia-Pacific Association of Gastroenterology Chronic Constipation Consensus 2026.

Background/Aims: : Chronic constipation is a common gastrointestinal (GI) disorder in Asia, characterized by heterogeneous symptom presentation, frequent overlap with other GI symptoms, and limited access to specialized diagnostic tests in many settings. These factors contribute...

A Surgical Algorithm for Upper Cervical Trauma Based on the AO Spine Upper Cervical Injury Classification System

Study Design. Global cross-sectional survey Objective. To establish a surgical algorithm for upper cervical spine injuries using the AO Spine Upper Cervical Injury Classification (UCIC) system, defining operative thresholds using a novel proposed Upper Cervical AO-Spine Injury Sc...

Mitophagy and Noncoding RNA Regulation in Type 2 Diabetes Mellitus: Molecular Mechanisms, Tissue-Specific Evidence and Translational Perspective

Despite significant therapeutic advances, T2DM remains a global public health challenge that leads to multiple complications, including cardiovascular, renal, hepatic, and neurodegenerative disorders. Mitochondrial dysfunction and impaired mitophagy remain fundamental, yet incomp...

Small Airway Dysfunction Affects One in Five Indian Adolescents: The Multicity APEAL Study

Summary Small airway dysfunction affected one in five adolescents and varied substantially across four Indian cities. Age, sex and study city, but not ambient PM 2.5 or NO 2 , were independently associated with FEF 25–75 .