Albert Einstein College of Medicine

Healthcare Utilization in Patients With Chronic Rhinosinusitis With Nasal Polyps – Analysis of the Reg-ent Clinical Data Registry

Background Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) who fail medical management are often offered endoscopic sinus surgery (ESS). Dupilumab is also used to treat patients with inadequately controlled CRSwNP. Objective This retrospective cohort study uses a...

Patient-Specific Mirrored Planning Leads to Superior Symmetry for Late Post-Traumatic Deformity After Orbital Zygomatic Maxillary Complex Fractures

Background: Post-traumatic orbital-ZMC deformity is notoriously difficult to correct because of soft tissue contraction and loss of anatomic landmarks. To see whether virtual planning is beneficial, we studied orbital/malar volume correction, globe position, malar projection and...

Kynurenine Pathway Activation is Associated with Poor Sleep Efficiency in Men With HIV

Background: Sleep disturbances are common in people with HIV, yet the underlying biological mechanisms remain poorly understood. Chronic immune activation in HIV can induce the tryptophan-kynurenine (TK) pathway, which both reduces melatonin synthesis and increases production of...

Early Pregnancy Use of Anti-CGRP Monoclonal Antibodies and Propranolol and Spontaneous Abortion Risk

Importance Migraine affects individuals of reproductive age, but treatment options during pregnancy are limited due to safety concerns. Anti-calcitonin gene-related peptide (CGRP) monoclonal antibodies (mAbs) are effective for migraine prevention; however, CGRP is important in pl...

Global Incidence of All-Cause Dementia

Importance Global dementia incidence estimates are limited by underrepresentation of low- and middle-income countries and heterogeneous analytic methods. Due to these limitations, true understanding of the global dementia landscape remains incomplete. Objective To identify dement...

Opioid use, disability, and patient‐reported cognitive impairment in migraine: Multi‐country results from the Chronic Migraine Epidemiology and Outcomes—International Study

OBJECTIVE: To characterize the population who do and do not use opioids to treat migraine in the Chronic Migraine Epidemiology and Outcomes-International (CaMEO-I) Study. BACKGROUND: Opioids are not recommended for migraine treatment because of efficacy and safety limitations. ME...

Neutrophil-derived S100A8/A9 is associated with inflammation that supports Dnmt3a-mutant hematopoiesis

Not available.

A systematic review of hydrocephalus and psychiatric comorbidities in children and adults with spina bifida

Spina bifida in children and adults is accompanied by substantial psychiatric comorbidity. Hydrocephalus is a common complication of spina bifida and is associated with functional and cognitive deficits, but the role of hydrocephalus in psychiatric comorbidities of spina bifida i...

Macrophage Smad1 drives post-infarction dysfunction by reducing angiogenesis and by promoting matrix remodeling

AIMS: Infarct macrophages undergo dramatic phenotypic changes in response to cytokines and growth factors and serve as central effectors in cardiac repair and remodeling. Transforming Growth Factor (TGF)-β superfamily members are key regulators of macrophages and signal predomina...

Decline of chaperone-mediated autophagy in aging impairs macrophage clearance of senescent cells

Autophagy dysfunction and senescence are established drivers of aging, but their potential interaction remains poorly understood. Here we show that age-related decline of chaperone-mediated autophagy (CMA), a pathway for selective lysosomal protein degradation, changes senescent...

Incidence and Predictors of Complications After Transcatheter Aortic Valve Implantation According to VARC‐3 Criteria: A Systematic Review and Meta‐Analysis

BACKGROUND: Despite continuous advancements in devices and techniques, transcatheter aortic valve implantation remains associated with complications impacting outcomes. In 2021, the Valve Academic Research Consortium (VARC) introduced the VARC-3 criteria to better classify proced...

Expanded protocadherin-1 usage reveals a broader hantavirus entry landscape

Mammalian hantaviruses are RNA viruses that cause hantavirus cardiopulmonary syndrome in the Americas and hemorrhagic fever with renal syndrome in Eurasia. The cellular entry mechanisms of most hantaviruses remain poorly defined. To examine entry by phylogenetically distinct hant...

Ventricular Arterial Coupling as a Marker of Early Cardiotoxicity in Survivors of Childhood Cancer

Abstract Improved childhood cancer survival has been accompanied by substantial late morbidity and mortality related to cardiotoxic cancer therapies. We conducted a retrospective study of childhood cancer survivors (CCS) diagnosed before age 21 and followed at The Children’s Hosp...

Patterns of head and neck pain and obstructive sleep apnea in women with macromastia: A cross‐sectional analysis

Abstract Objectives/Background Symptomatic macromastia, or breast hypertrophy, is associated with musculoskeletal and neurological symptoms, including headache and neck pain. Though insurers list headache as an indication for breast reduction surgery, its relationship to specific...

Early improvements in function with atogepant as assessed by the Activity Impairment in Migraine–Diary: Post hoc analyses of three randomized, phase 3 clinical trials of atogepant for the preventive treatment of migraine

Abstract Objective Evaluate early functional improvements with the preventive migraine treatment atogepant using Activity Impairment in Migraine–Diary (AIM‐D) individual and activity limitation items, and complete improvement in AIM‐D Performance of Daily Activities (PDA) and Phy...

Prayer and acute pain sensitivity in migraine and non-migraine cohorts: two assessor-blinded crossover experiments

Prayer is a widely used coping strategy that engages affective and cognitive processes implicated in pain regulation. Despite growing interest in the effects of religion and spirituality in health research, experimental evidence linking prayer to quantitative sensory outcomes in...

Predictors of cancellation and rescheduling of elective shoulder arthroscopy: Experiences at an urban academic medical center

ABSTRACT Background: Cancellation of elective shoulder arthroscopy negatively affects the surgical scheduling process and results in significant financial loss for a health care institution. Despite this, the patient-related and surgical-related risk factors of cancellation remai...

Strategies for the Care of Mothers With Substance Use Disorder

Substance use disorder and opioid use disorder in pregnancy have serious maternal and neonatal sequelae, including neonatal abstinence syndrome, preterm labor, and intrauterine growth restriction. Despite this, there are limited resources and guidelines to help clinicians support...

Per- and polyfluoroalkyl substances levels other than PFOS, PFOA, or PFHxS and liver cancer risk: a nested case-control analysis

Abstract Epidemiologic studies of PFAS and liver cancer risk have produced conflicting results with no strong or clear associations for pre-diagnostic perfluorooctanesulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorohexanesulfonate (PFHxS). We now report analyses of nine...

Mindfulness and Posttraumatic Stress Symptoms in Mothers of Children With Pediatric Cancer

Background: Mothers are often identified as the primary caregiver, thus at unique risk for psychological sequelae of their child’s cancer, including elevated posttraumatic stress symptoms (PTSS). Studies have shown greater mindfulness is often associated with lower PTSS across po...