Albert Einstein College of Medicine

Current Trends in Therapeutic Outcomes Among Patients With Metastatic Renal Cell Carcinoma of the Spine: A Systematic Review and Meta-Analysis

Study Design Systematic Review. Objectives The objective of this study was to answer two questions: (1) Did the overall survival (OS) of patients with spinal metastatic renal cell carcinoma (mRCC) improve in publications from 2017 and afterwards compared to 2016 and before? (2) D...

Menopausal hormone therapy and primary liver cancer: long-term follow-up of the women’s health initiative randomized trials

Abstract Background: Long-term results on liver cancer incidence and mortality are reported from two Women’s Health Initiative randomized trials evaluating menopausal hormone therapy. Methods: 16,608 postmenopausal women with a uterus were randomized to conjugated equine estrogen...

Manipulation of host response and trajectory of parasite survival: A damage-response framework perspective

Manipulation of Host Response and Trajectory of Parasite Survival: A Damage-Response Framework Perspective

Anterior interosseous to extensor carpi radialis brevis nerve transfer for wrist extension in brachial plexus birth injury

Abstract Brachial plexus birth injuries (BPBI) affecting the C5 to C8 nerve roots commonly impair wrist extension, making its restoration a key goal of reconstruction. However, children with persistent wrist extension paralysis have limited surgical options, particularly in the s...

Performance of the iBox Prognostication System in African American Kidney Transplant Recipients

Background: The iBox is a validated prognostication system that predicts long-term death-censored graft loss in kidney transplant recipients, but its performance in the specific population of African American recipients has not been fully studied. Methods: We conducted a multicen...

The Impact of v‐SYMPHONY's Virtual Boot Camp on Trainee Transition From Residency to Fellowship

BACKGROUND: Starting a pediatric subspecialty fellowship presents numerous challenges to trainees. Virtual Symposium of Pediatric Hematology/Oncology of New York (v-SYMPHONY), an educational collaborative organized by 18 pediatric hematology-oncology (PHO) programs, initiated an...

Neocortical long-range inhibition promotes cortical synchrony and sleep

Abstract Sleep and wakefulness are associated with distinct cortical patterns of rhythmic activity 1 . During low-arousal states such as slow-wave sleep, synchronous low-frequency rhythms dominate activity across widespread cortical regions. Although inhibitory neurons are increa...

Deactivation Neural Ordinary Differential Equation (deactNODE)─Learning Deactivation Kinetics from Integral Data

Abstract Catalyst deactivation critically affects the long-term reactor performance. Thus, the development and parametrization of accurate models to predict the effect of operation conditions is crucial for reactor design. Current models are limited by power-law frameworks or lac...

Endoscopic Iliotibial Band Lengthening and Bursectomy Effectively Improve Pain and Function in Patients With Greater Trochanteric Pain Syndrome

Purpose To evaluate patient‐reported outcomes after endoscopic bursectomy and iliotibial band lengthening for the treatment of greater trochanteric pain syndrome. Methods Patients >18 years who underwent endoscopic bursectomy and iliotibial band lengthening for treatment of great...

Revisiting the Original Narakas Classification of Brachial Plexus Birth Injuries

Purpose Accurate classification of brachial plexus birth injury (BPBI) is critical for predicting outcomes and guiding early intervention. In 1987, Narakas introduced the first widely adopted system. Over time, misquotations and reinterpretations have obscured the work, conflatin...

Prenatal Water Fluoride Exposure and Children’s Behavioral Problems

Importance Although fluoride exposure at high levels during the perinatal period has been associated with socioemotional problems among children, there is limited evidence regarding potential associations at lower levels of fluoride exposure, particularly in the US. Objective To...

Evolving Treatment Options for Spinal Pain: Balancing Innovation and Affordability in Regenerative Medicine

Abstract Purpose of Review Regenerative approaches for treating spinal pain hold great clinical promise but have the potential to disrupt healthcare upending the cost paradigm of pharmacologic care or interventional procedures. Regenerative approaches have higher upfront costs bu...

Superlarge-Bore Versus Large-Bore Aspiration Catheters in Mechanical Thrombectomy: A Multicenter Propensity-Matched Analysis

BACKGROUND AND OBJECTIVES: Aspiration catheters are an integral component of mechanical thrombectomy for acute ischemic stroke (AIS). Following early series demonstrating increasing procedural efficiency and improved outcomes with use of large-bore (LB) aspiration catheters, ther...

Beyond stenosis: imaging phenotyping and risk stratification in nonobstructive coronary artery disease

Purpose of review Nonobstructive coronary artery disease (NOCA) is now frequently detected by coronary CT angiography (CCTA), but the term compresses biologically distinct patterns into a single anatomic label. This review examines how CT-derived markers can reorganize NOCA aroun...

Nipocalimab for warm autoimmune hemolytic anemia: results from the phase 2/3 randomized, double-blind ENERGY study

Warm autoimmune hemolytic anemia (wAIHA) is a rare, life-threatening disease characterized by autoantibody-mediated destruction of red blood cells with no approved treatments. Nipocalimab, an immunoselective neonatal Fc receptor blocker, reduces circulating IgG levels, including...

“A Split-Muscle Support Technique for Direct-To-Implant Breast Reconstruction”

Many patients who undergo direct-to-implant breast reconstruction with subpectoral implant placement experience animation deformity, where implants move up toward the axilla with contraction of the pectoralis muscle. The deformity affects quality of life and prompts patients to s...

Quality Improvement Initiative to Increase Newborn RSV Immunization

BACKGROUND: Respiratory syncytial virus (RSV) is a major cause of respiratory illness in infants. In 2023, the Food and Drug Administration approved 2 methods of RSV prevention: birthing parent bivalent RSVpreF vaccine and infant nirsevimab monoclonal antibody. During the 2023-20...

Crimean-Congo hemorrhagic fever virus protein GP38 from isolate M18-China confers broad immunological breadth

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne, negative-strand RNA virus that causes outbreaks of lethal hemorrhagic fever. No approved vaccines or specific antiviral treatments are available. CCHFV glycoprotein GP38 is an integral component of the pre-fusion glyc...

Reduced dosage of Kmt2d modifies Tbx1 haploinsufficiency toward phenotypes of 22q11.2DS

Haploinsufficiency of TBX1 , which occurs in 22q11.2 deletion syndrome (22q11.2DS), leads to a heterogeneous spectrum of clinical manifestations, including craniofacial anomalies, immunodeficiency, and congenital heart defects. The variability in syndromic presentation between pa...

Postoperative inflammatory markers and surgical wound infection after elective short-segment lumbar fusion: the importance of surgical context

Abstract. Introduction: Postoperative white blood cell (WBC) count and neutrophil-to-lymphocyte ratio (NLR) are routinely available after lumbar fusion, but early elevations may reflect surgical stress. We evaluated associations of postoperative day (POD) 1 and POD3 WBC/NLR with...