Albert Einstein College of Medicine

Association between exposure to air pollution and age at natural menopause: The Study of Women's Health Across the Nation.

CONTEXT: Air pollution is a recognized risk factor for women's subfertility, yet its association with the timing of natural menopause remains understudied. OBJECTIVES: To examine the association between exposure to ambient air pollution and age at natural menopause (ANM). DESIGN...

Postoperative inflammatory markers and surgical wound infection after elective short-segment lumbar fusion: the importance of surgical context

Abstract. Introduction: Postoperative white blood cell (WBC) count and neutrophil-to-lymphocyte ratio (NLR) are routinely available after lumbar fusion, but early elevations may reflect surgical stress. We evaluated associations of postoperative day (POD) 1 and POD3 WBC/NLR with...

Patterns and perceptions of supplement use among patients with plasma cell disorders

As novel treatments have improved survival in patients with plasma cell disorders (PCDs), there is a growing interest in complementary medicine (CM), particularly dietary supplements (vitamins, minerals, antioxidants, and herbs), amongst patients with cancer [ 1 ]. Multiple myelo...

Investigation of In Situ Cross-linked Polyacrylic Acid-PEG Binder for Si-dominant Anodes in Lithium-Ion Full Cells

Abstract Silicon (Si) is a highly promising anode material for lithium-ion batteries due to its high theoretical capacity. However, its practical use is limited by significant volume changes and resulting degradation during cycling. To enhance the mechanical stability of the Si a...

From Posts to Perceptions: How Reddit Users Feel About Phalloplasty and Metoidioplasty

Abstract Gender-affirming surgery, including phalloplasty and metoidioplasty, has demonstrated efficacy in alleviating gender dysphoria in appropriately selected patients. This study aims to better describe the needs and priorities of patients undergoing these procedures by using...

Decreased cerebrospinal fluid NDRG2 is associated with non-Alzheimer's disease derived mild cognitive impairment

Background Mild cognitive impairment (MCI) lacks clear clinical biomarkers. N-Myc downstream-regulated gene 2 (NDRG2) is predominantly localized in astrocytes and is implicated in cognitive function. Objective This study aims to explore whether cerebrospinal fluid (CSF) NDRG2 cou...

Linking Air Pollution and Hematologic Malignancies: From Epidemiology to Molecular Mechanisms

PURPOSE OF REVIEW: Outdoor air pollution (OAP) is a major global environmental health threat associated with respiratory disease and solid tumors, with growing evidence linking it to hematologic malignancies. This review summarizes the molecular mechanisms and epidemiologic evide...

Weight and Glycemic Outcomes Following GLP-1 Receptor Agonist Therapy in People Living with HIV: A Retrospective Study at a Bronx Hospital

Background/Objectives: People living with HIV (PLWH) who undergo prolonged antiretroviral therapy (ART) may experience weight gain as a potential side effect. Many of these individuals are prescribed glucagon-like peptide 1 (GLP-1) receptor agonists (RAs), or dual GLP-1 and gluco...

ProtLID2.0: A Residue-SpecificPharmacophore Frameworkfor Protein–Protein Docking

Abstract Predicting biologically relevant protein–protein interactions remains a major challenge in structural biology. Here, we present ProtLID2.0, a residue-specific pharmacophore framework that generates coordinate-based interaction preferences from molecular dynamics simulati...

Mena EVH1 Interactswith PTP1B Via a Distributed InterfaceWithout Regulating Enzymatic Activity

Abstract The interaction between mammalian enabled protein (Mena), an actin regulatory protein, and protein tyrosine phosphatase 1B (PTP1B) is critical for maintaining epidermal growth factor receptor (EGFR) signaling homeostasis and regulating cellular motility. Mena recruits PT...

Manganese transport, homeostasis, and neurotoxicity

Manganese (Mn) is an essential metal required for many physiological functions, and deficiency or over-exposure is associated with neurological dysfunction and neuropathology. Tight homeostatic control of Mn in the body is required to maintain optimal physiological levels and pro...

Incidence of new-onset pulmonary fibrosis 4.5 years post SARS-CoV-2 infection in an academic urban medical center

The long-term risk of clinical new-onset pulmonary fibrosis (PF) and its various downstream impacts following SARS-CoV-2 infection remain incompletely characterized in existing literature. A retrospective cohort was analyzed using Montefiore Health System electronic health record...

TRAIL splice variant TRAILshort disrupts T cell receptor signaling and promotes immune tolerance in vivo

TRAIL is a TNF family ligand that trimerizes TRAIL-R1 (DR4) or TRAIL-R2 (DR5) to induce apoptosis, necroptosis, and/or NF-κB activation in receptor-bearing cells. We previously identified TRAILshort as a splice variant of TRAIL that lacks cysteine 230, cannot trimerize, and acts...

Something Doesn’t Look Right: Recognizing and Managing Limb-Length Discrepancy

Leg length discrepancy (LLD) is a frequently encountered yet often underrecognized musculoskeletal condition in children. Minor differences in leg length are common and typically benign; however, more significant discrepancies may reflect underlying congenital, developmental, or...

The establishment of prostate-specific, SKP2 humanized mice by CRISPR knock-in method reveals neoplastic initiation and microenvironmental reprogramming

Abstract A recent study has shown that SKP2 inactivation can prevent cancer initiation by extension of total cell cycle duration without perturbing normal division, which suggests a new strategy for cancer prevention. However, direct in vivo evidence for human SKP2 on cancer init...

Standardizing Fertility Preservation Counseling for Pediatric Hematology–Oncology and Transplant and Cellular Therapy Patients: A Quality Improvement Initiative

BACKGROUND: Infertility following gonadotoxic chemotherapy is among the most distressing late effects experienced by childhood cancer survivors, highlighting the importance of fertility preservation (FP) counseling at the time of diagnosis. We aimed to improve the frequency and c...