Aix-Marseille Université

Appendicular Versus Non-Appendicular Community-Acquired Intra-Abdominal Infections: A Post-Hoc Analysis of the PERICOM Multicenter Study

Background: Community-acquired intra-abdominal infections (CA-IAIs) exhibit significant clinical heterogeneity. However, most studies focusing on CA-IAIs do not stratify comparisons by infection site. Methods: This post hoc analysis of the prospective multicenter PERICOM cohort (...

Data-driven mean-field within whole-brain models

Mean-field models provide a link between microscopic neuronal activity and macroscopic brain dynamics. Their derivation depends on simplifying assumptions, such as all-to-all connectivity, limiting their biological realism. Here, we introduce a data-driven framework in which a mu...

Micro-scale organization of non-cyanobacterial diazotrophs drives nitrogen fixation in marine particles

Abstract Dinitrogen (N₂) fixation supplies reactive nitrogen to the ocean, and non-cyanobacterial diazotrophs (NCDs) are increasingly recognized as contributors. Marine particles have been theorized as hotspots where low oxygen and labile carbon favor N₂ fixation by NCDs, but emp...

Protein polymers proliferate: polymerization of phosphatases and proteases

It has been known for more than half a century that enzymes can polymerize to either activate or repress their catalytic functions. Using electron cryo-microscopy (cryo-EM), we serendipitously found that two commonly used enzymes in molecular microbiology research, alkaline phosp...

A novel 5-FU derivative chemotherapy: a promising pan-cancer treatment to improve antitumor efficacy and overcome therapy resistance

Abstract Management of advanced solid cancers remains challenging, particularly after the development of therapeutic resistance. Here, we synthesized a library of phosphonium-substituted 5-fluorouracil (5-FU) derivatives and evaluated their anticancer activity across multiple tum...

The Impact of Common Medications on Male Fertility: An Updated Systematic Review

ABSTRACT Background Compared with those of cytotoxic treatments, the potential effects of common medications on the fertility of men trying to conceive currently or planning to conceive in the future are less well described. The use of common medications may modify the gonadotrop...

Benchmarking Core-Level X-ray Absorption with MRSF-TDDFT, RASPT2, and Stochastic GAS Using the XABOOM Set

Abstract Rapid advances in X-ray free-electron laser facilities are producing X-ray absorption spectra (XAS) with unprecedented detail, creating a pressing need for theoretical methods that are both accurate and computationally efficient to interpret subtle spectral features. In...

Inhibition of oxytocin neurons during key periods of development has long-term behavioral and body composition effects

Abstract Background: Oxytocin (OT) is a key neuromodulator of social behavior in mammals, and accumulating evidence supports the existence of a critical period for OT action during infancy. However, other developmental windows remain poorly explored, and it remains unclear whethe...

Dynamic Trajectory Planning for Urban Traffic Using Deep Learning-Based Traffic Prediction

Abstract Traditional trajectory planning systems in navigation applications generate routes based on the current traffi conditions at the time of departure. However, traffi dynamics are highly variable, and aroute that is initially optimal may become congested during the trip, le...

The Development of Compositionality in Language and Thought

Compositionality is the property of a representational system whereby complex meanings arise from the combination of simpler meaningful elements. Here we take a developmental perspective to understand the origins of compositional representational systems and their relation to lan...

Unravelling Motivations, Collaborative Behaviour and Success of Lifestyle Entrepreneurs: A Cluster Analysis

Abstract Purpose This study aims to deepen the understanding of lifestyle entrepreneurs (LEs) by analysing their personal entrepreneurial motivations and examining how these motivations are related to their alliance orientation and business success, defined through firm performan...

Characterization of diseases in temporal comorbidity networks

Comorbidity networks, or disease-disease networks, represent relationships between diseases and can reveal non-random disease associations and multimorbidity structure. These patterns reflect shared pathophysiology, diagnostic pathways, and risk of adverse outcomes. Using large-s...

Chiral by Nature: Chiroptical Activity in Fe3O4 Magnetic Nanoparticles from Bacterial Biomineralization

Abstract The coexistence of chirality and magnetism in nanomaterials has been observed with metallic complexes but remains rarely achieved in magnetic oxides. Here, we identify biologically induced chiroptical activity in the magnetotactic bacterium Magnetospirillum gryphiswalden...

Kissing Number of Codes: A Survey

The kissing number of a code is the average number of pairs of codewords at minimum distance from each other. It has fundamental applications in determining code performance. Besides, a recent interest has arisen from the field of side-channel analysis of algorithms handling sens...

Elements on the move: How ungulate migration expands Alpine biogeochemical footprints

Through depositing waste products, animals influence the spatial distribution of elements across landscapes. Yet the relationship between animal movement and element distribution remains poorly characterized. We developed a spatially explicit agent-based model to test how migrato...

Experimental three-dimensional dendrite tip shape characterization by interferometry and phase-field comparison during columnar directional solidification

International audience

Volumetric and functional connectivity alterations of the thalamus and thalamic nuclei groups in drug-resistant focal epilepsy: A 7T MRI study

Abstract Purpose Through its global and extensive connections with multiple brain structures, the thalamus can play an important role in seizure propagation. This study investigated volumetric and functional connectivity alterations of the thalamus and more specifically the thala...

Hippocampal Seizure‐Related Burden is Associated with Accelerated Long‐Term Forgetting in Focal Epilepsy

Objective Memory impairment is a frequent comorbidity of focal epilepsy, incompletely explained by seizure frequency or structural pathology. Ictal and postictal hippocampal dysfunction disrupt memory processes, but their cumulative impact remains poorly quantified. This study in...

Classification of Seasonal Allergic Rhinitis Patients by Prospective Patient‐Recorded Symptoms: The @ IT .2020 Project

BACKGROUND: Seasonal allergic rhinitis (SAR) has been so far classified according to frequency and severity by retrospective information based on the ARIA (Allergic Rhinitis and its Impact on Asthma) classification. Electronic symptom diaries (e-Diaries) are feasible tools to col...

Similarity laws for experimental assessment of the thermal efficiency of a wall with optimized shape submitted to two-dimensional heat transfer

To assess the energy efficiency of wall prototypes with advanced designs, real scale experimental demonstrators are difficult and expensive projects. To address this issue, this study develops a reduced scale experimental demonstrator based on similarity laws established for a pr...