Aix-Marseille Université

Online Learning-Based Adaptive Hybrid Benders Decomposition for Risk-Averse Optimal Sizing

Optimal sizing problem (OSP) under uncertainty is often formulated as two-stage stochastic programming (2SP). However, this formulation typically introduces significant computational and RAM (memory) bottlenecks as the scenario size grows. Benders Decomposition (BD) is a popular...

Cross-protection of wildtype and vaccine-derived chikungunya virus antibodies against chikungunya and Mayaro viruses in mice

Abstract The live-attenuated vaccine IXCHIQ against chikungunya virus (CHIKV) was approved in 2023, with its efficacy evaluated using human neutralizing antibody titers as surrogate effectiveness criterion. Previous in vivo studies assessed its efficacy at high CHIKV-specific ant...

Can machine learning be used to quantify blood loss based on hemodynamic data? Experimental study of controlled hemorrhagic shock in anesthetized piglets

Background Hemorrhagic compensatory physiological mechanisms may initially lead to an underestimation of the severity of a hemorrhage, for which quantification of blood lost volume is difficult. The objective of our study was to assess the suitability of machine learning (ML) to...

Ultrathin Cerium Oxide Islands on Cu(111): Work Function and Reaction with Oxygen and Hydrogen at RT

Abstract Ultrathin oxide films can significantly change the work function (WF) of metal surfaces, with large consequences for the adsorption of nanoparticles and molecules on the films. In contrast to other oxides, little is known about the impact of ultrathin cerium oxide (ceria...

Knowledge, attitudes, and practices about severe mental illness and willingness-to-pay for a new integrated care model across 6 European countries: a study protocol

Background People with Severe Mental Illness (SMI) experience a 15–20-year shorter life expectancy than the general population, with increased premature deaths from somatic illnesses, and twice to more than four times the general population’s all-cause mortality risk. Integrated...

Energy expenditure of bonobos across their locomotor repertoire

Unlike quadrupedal mammals, primates use diverse locomotor modes adapted to arboreal environments. Such diversity of movements challenges allometric models, which underestimate energetic costs by focusing on steady-state walking. To address this, we combined ethological and biome...

Sampled-Based Guided Quantum Walk: Non-variational quantum algorithm for combinatorial optimization

We introduce SamBa-GQW, a novel quantum algorithm for solving binary combinatorial optimization problems of arbitrary degree with no use of any classical optimizer. The algorithm is based on a continuous-time quantum walk on the solution space represented as a graph. The walker e...

Management of hemodynamically stable penetrating chest trauma without cardiac injury in Marseille

Abstract Background Penetrating chest trauma (PCT) is uncommon in Western Europe but carries substantial morbidity. Non-operative treatment (NOT) is widely practiced in regions with high rates of penetrating injuries, whereas European centers continue to report higher surgical ex...

Contraceptive use in women of childbearing age with bipolar disorder

INTRODUCTION: Unplanned pregnancies are frequent in women with bipolar disorder (BD) while perinatal period is associated with a higher risk of relapse. Effective contraception during childbearing age in BD could reduce the risk of unplanned pregnancy and its consequences. The pr...

Magnetic granular matter: A review of phenomena and modeling approaches

Abstract Magnetic granular matter extends classical granular physics through the introduction of tunable, long-range dipolar interactions. These interactions give rise to a wide range of collective phenomena, including field-aligned chain formation, enhanced cohesion, anisotropic...

How does explicit reliability guide choices? Effect of trustworthiness on choice and metacognition

A key challenge in today’s fast-paced digital world is to integrate information from various sources, which differ in their reliability. Yet, little is known about how explicit probabilistic information about the likelihood that a source provides correct information is used in de...

Two millennia of Caspian Sea level change and Hyrcanian forest dynamics: A multi-proxy record from the Anzali Lagoon, northern Iran

A multi-proxy study of a 5-m-long sediment core from the Anzali Lagoon (southwest Caspian coasts) was conducted to reconstruct Caspian Sea level fluctuations and concurrent vegetation history in the Hyrcanian forests over the past two millennia. The record reveals several major t...

Evaluating age-related differences in motor imagery in children aged 5 to 8: feasibility and task-specific modulation

Motor imagery (MI), the mental simulation of movement without execution, provides a behavioural tool to evaluate sensorimotor representations. However, its characterisation in young children remains debated. This study investigated age-related differences in MI across early prima...

Self-assembled nucleolipid G-quadruplexes act as multitarget decoys for oncogene suppression in pancreatic cancer

Abstract KRAS mutations drive multiple cancers and represent an important therapeutic target, together with other oncogenic regulators such as MYC , KIT , and BCL2 that are critically involved in pancreatic cancer. Here we describe a novel therapeutic strategy based on stable nuc...

Beyond likes: when influencer relationships translate into e-entrepreneurial intentions through opportunity recognition and self-efficacy

Purpose Drawing on the social cognitive theory, this study aims to examine how and when parasocial relationships with social media influencers shape e-entrepreneurial intentions. Specifically, the authors investigate entrepreneurial opportunity recognition as a mediating mechanis...

Early-warning surveillance of West Nile and Usutu viruses in wetland and larval habitat waters and in mosquito excreta using digital PCR

West Nile virus (WNV) and Usutu virus (USUV) are mainly avian mosquito-borne pathogens, increasingly cause human and equine disease in temperate regions. Mostly asymptomatic, current surveillance in France is reactive, based on clinical and veterinary reports, delaying signals fo...

CardamomOT: A mechanistic optimal transport-based framework for gene regulatory network inference, trajectory reconstruction and generative modeling

A key challenge in inferring gene regulatory networks (GRNs) governing cellular processes such as differentiation and reprogramming from experimental data lies in the impossibility of directly measuring protein dynamics at the single-cell level, which prevents establishing causal...

CRB3 and ARP2/3 regulate cell biomechanical properties to set epithelial monolayers for collective movement

Several cellular processes during morphogenesis, tissue healing or cancer progression involve collective cell migration. To set the cells for motion, there is an initial breaking of organization of the epithelial tissue that modifies the epithelial phenotype and axis of polarity....

NKCC1 coordinates SPAK-PP1 signalling to regulate KCC2 membrane stability and seizure susceptibility.

Chloride homeostasis, and thereby the efficacy of chloride-permeable GABAA receptor signaling, depends on the dynamic balance between NKCC1 (Na+-K+-2Cl- cotransporter 1) and KCC2 (K+-Cl- cotransporter 2), which respectively mediate chloride influx and extrusion to tightly control...

Ultrafast Micrometric Laser Structuring of Polymer Surfaces for Highly Organized Skeletal Muscle Tissue Modeling

ABSTRACT Engineered surface topographies have proven to be an efficient method to replicate in vitro the architecture of highly organized tissues by controlling the spatial arrangement of cells. In this work, we studied the ability to guide muscle cell development using femtoseco...