Aix-Marseille Université

Biomarkers in facioscapulohumeral muscular dystrophy

PURPOSE OF REVIEW: Facioscapulohumeral muscular dystrophy is one of the most frequent myopathies. Its clinical presentation and genetic background are unique. FSHD needs reliable and measurable biomarkers to monitor the disease and assess the efficacy of therapeutic approaches. T...

Ultraslow brain dynamics as neurophysiological markers of information sampling during learning

To learn, we must actively sample information from our environment: selecting, prioritizing, and extracting relevant cues. Here, we investigated whether ultraslow event-related potentials (ERPs) could track information sampling as participants learned new words from sentence cont...

Magnetic Field Tuning of Modulated Magnetic Orders in CrOCl at the Two‐Dimensional Limit

Chromium oxychloride is a van der Waals magnet with intrinsic competing exchange interactions, including a strong antiferromagnetic one, source of a very rich magnetic phase diagram, with ferrimagnetic, antiferromagnetic, and canted states, up to high magnetic fields. We investig...

Entropy maximization and weak Gibbsianity of quasi-free fermionic states

Abstract In their 1972 study of approach to equilibrium, Lanford and Robinson showed that gauge-invariant quasi-free states of lattice fermions maximize entropy among all translation-invariant states with a fixed two-point function and suggested that the maximizer is unique. In s...

Scaffold, Not Seed -- Except One: Positional Encoding and the Emergent Group Representations of Grokking Transformers

A small transformer that groks modular addition famously discovers the Fourier representation of Z/p on its own. Prior work asks what algorithm is learned and which irreducible representations are used, always with the architecture held fixed. We ask one level up the causal chain...

Transposed-letter effects as a function of the location of transpositions

We examined how Transposed-Letter effects (TL effects: e.g., ASBENT, derived from ABSENT, compared to the substituted-letter [SL] control ALPENT) might vary as a function of the location of the TL effects relative to fixation. The positions of the TL and the initial fixation loca...

What does a territory tell? Co-constructing heritage through complex social values in inner contexts

Italian inner areas are increasingly affected by depopulation, demographic ageing, and territorial fragmentation. In these contexts, cultural heritage is frequently mobilised as a resource for local development and regeneration. While heritage studies have widely recognised that...

Detection of spiking motifs of arbitrary length in neural activity using bounded synaptic delays

In the context of spiking neural networks, the temporal coding hypothesis is increasingly preferred over the rate coding hypothesis due to its advantages in processing speed and energy efficiency. In temporal coding, synaptic delays are crucial for processing signals with precise...

Quality of life assessment in individuals with schizophrenia: a COSMIN-based systematic review of S-QoL41 and S-QoL18 incorporating neurobiological support

Background Quality of life is a key outcome in schizophrenia, requiring valid patient-reported outcome measures. We evaluated Schizophrenia Quality of Life (S-QoL) instruments. Methods We searched PubMed, PsycINFO, and Web of Science from inception to Dec 10, 2025. Measurement pr...

Widespread thermophilization but weak link to climate warming in Europe’s summit plant communities

Abstract Recent changes in alpine vegetation are often attributed to climate warming, particularly community composition shifts towards more warmth-associated species, or thermophilization. Here we assess the link between thermophilization and warming across 53 European mountain...

GRB 260310A / SN 2026fgk: A Multi-Wavelength Study of a Nearby Underluminous Long GRB and SN with a Complex Afterglow

Abstract We present a comprehensive multi-wavelength study of GRB 260310A / SN 2026fgk, a nearby (z = 0.153), long-duration gamma-ray burst (GRB) with an exceptionally underluminous prompt γ-ray emission and a Comptonized spectrum. The burst occurred at the edge of a blue host ga...

Iron Isotopes Reveal Fe Export Driven by Change of Tropical Weathering Regime

Abstract Unraveling paleoenvironmental signals recorded in laterites is crucial for quantifying weathering‐driven elemental fluxes at the Earth's surface. New stable iron isotope data (δ 56 Fe), combined with (U‐Th)/He ages in Fe‐oxides from a ferruginous duricrust from French Gu...

Measuring masses of transiting Earth-like planets: first insights from the PLATO RV Data Challenge

Abstract The PLATO Stellar Variability Mitigation Working Group designed a radial-velocity (RV) data challenge to assess the precision and accuracy achievable on RV semi-amplitudes in the context of the future PLATO follow-up. Using Sun-as-a-star observations obtained with HARPS-...

High‐Detectivity InGaAs/GaAsP Superlattice PIN Photodetector with a Thin Absorber on GaAs substrate for 1100 nm Applications

ABSTRACT III‐V materials exhibit superior optoelectronic properties compared to conventional semiconductors, making them ideal for short‐wavelength infrared (SWIR) photodetectors. These devices are in demand for applications such as telecommunications, LiDAR, and biomedical engin...

Zippers and Twisters: Planes of Satellite Galaxies Emerge from Whirling and Shocking Gas Streams in the Cosmic Web

Abstract We investigate dwarf satellite systems around massive centrals analogs (Milky Way to Centaurus A) in the NewHorizon simulation. Using simple estimators limiting overdetection, we identify planes of satellites comparable to observations in 30%–70% of cases. The full sampl...

An Optimal Spray Device for the Nose-to-Brain Delivery of AmyP53, an Adaptive Therapeutic Peptide for Alzheimer’s and Parkinson’s Diseases

Background: Nose-to-brain delivery offers a noninvasive route to bypass the blood–brain barrier for the treatment of neurodegenerative diseases. AmyP53 is a first-in-class adaptive 12-mer peptide that prevents the formation of neurotoxic amyloid oligomers by competitively targeti...

Nuclear activities and interactome of the NS5 protein of tick-borne encephalitis virus

Orthoflaviviruses are RNA viruses responsible for significant diseases in humans, domesticated animals, and wildlife. Their NS5 protein is central in viral replication, functioning both as an RNA-dependent RNA polymerase and a methyltransferase, while also modulating cellular pro...

Characterising recent antimalarial resistance in West Africa: Insights from amplicon sequencing of 17,384 Plasmodium falciparum infection samples

<ns5:p> Background <ns5:italic>Plasmodium falciparum</ns5:italic> ( <ns5:italic>P. falciparum</ns5:italic> ) infection remains a significant public health threat in West Africa, where chemoprevention and first-line therapies are key interventions against malaria. However, the dev...

Budigalimab: a viable option for patients with advanced solid tumors

INTRODUCTION: Immune checkpoint inhibitors transformed lung cancer treatment and prognosis, new drugs are currently being developed to continue to improve patient's outcome and especially surrogate immune checkpoint for each pharma company pipeline. AREAS COVERED: We conducted a...

Effectiveness of health mediation to promote organised cancer screening among underserved and under-screened populations in Marseille, France: findings from a repeated cross-sectional survey

Abstract Background Since 2022, the “13 en Santé” health mediation program has been implemented in Marseille, France, to reduce social health inequalities, in socioeconomically disadvantage neighbourhoods, with a particular emphasis on promoting participation in population-based...