Jacqueline J. Horsford

Genomic Fit and Environmental Mismatch: The Tradeoff Model of Polygenic Operating Range

Why do "harmless" common genetic variants trigger catastrophic failures under specific environmental stress? Moving beyond reductionist "one-variant-one-disease" paradigms, this monograph introduces the Tradeoff Model of Polygenic Operating Range. It reframes common polymorphisms...

Schizophrenia as Terrain Fragility: A Terrain–Timing Model of Developmental State-Transition Vulnerability

Why does schizophrenia aggressively cluster around specific developmental windows like late adolescence? Rejecting single-cause neurochemical paradigms, this paper applies the framework of Terrain Fragility—a state of compressed adaptive reserve where networks function normally u...

Schizophrenia as Terrain Fragility: A Terrain–Timing Model of Developmental State-Transition Vulnerability

Why does schizophrenia aggressively cluster around specific developmental windows like late adolescence? Rejecting single-cause neurochemical paradigms, this paper applies the framework of Terrain Fragility—a state of compressed adaptive reserve where networks function normally u...

Cancer as Coherence Rescaling: A Terrain–Timing Model of Multicellular Constraint, Tumor-Level Cooperation, and Metastatic State Propagation

What if carcinogenesis is not a descent into chaotic entropy, but a survival shift to an entirely alternate layer of biological organization? This series finale applies the Terrain–Timing Model to oncology through the mechanism of coherence rescaling. It proposes that as organism...

Genomic Fit and Environmental Mismatch: The Tradeoff Model of Polygenic Operating Range

Why do "harmless" common genetic variants trigger catastrophic failures under specific environmental stress?Moving beyond reductionist "one-variant-one-disease" paradigms, this monograph introduces the Tradeoff Model of Polygenic Operating Range. It reframes common polymorphisms...

The Endocrine-Chronobiological Axis: Hormones, Lifespan Transitions, and Biological Operating Range

How do major lifespan transitions unmask hidden genetic vulnerabilities? This paper introduces the Endocrine-Chronobiological Axis, establishing hormone profiles as time-varying, internal modifiers of an organism's biological operating range. It reframes hormones from static cros...

Cancer as Coherence Rescaling: A Terrain–Timing Model of Multicellular Constraint, Tumor-Level Cooperation, and Metastatic State Propagation

What if carcinogenesis is not a descent into chaotic entropy, but a survival shift to an entirely alternate layer of biological organization? This series finale applies the Terrain–Timing Model to oncology through the mechanism of coherence rescaling. It proposes that as organism...

Amyotrophic Lateral Sclerosis as Declining Recovery Capacity

What if ALS progression is driven by a collapse in network recovery kinetics rather than a binary cellular trigger? This paper applies the Terrain–Timing Model to motor-neuron degeneration, operationalizing ALS as a progressive, non-linear collapse in the capacity of vulnerable m...

The Endocrine-Chronobiological Axis: Hormones, Lifespan Transitions, and Biological Operating Range

How do major lifespan transitions unmask hidden genetic vulnerabilities? This paper introduces the Endocrine-Chronobiological Axis, establishing hormone profiles as time-varying, internal modifiers of an organism's biological operating range. It reframes hormones from static cros...